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Full-Text Articles in Biomedical Engineering and Bioengineering
Novel Biomechanical Test Method For Cancellous Bone Screws And Screw Augmentation With Cement., Kevin Lancaster
Novel Biomechanical Test Method For Cancellous Bone Screws And Screw Augmentation With Cement., Kevin Lancaster
Electronic Theses and Dissertations
It is often difficult to achieve adequate screw fixation for plate constructs in fractures with poor quality bone or in metaphyseal bone with extensive bone loss or comminution[7][17]. Furthermore, rescuing or augmenting failed screw fixation in inadequate bone with various cement products has yielded mixed results when tested with pure axial pullout loading[20][21]. In most cases, plate/screw constructs experience both vertical (translational) and horizontal (pullout) forces during physiologic loading[17][20][21]. The increased use of locked screws in plate constructs has also changed the loading patterns of bone screws. For this study, a novel “toggle-out” testing method was developed to more realistically …
Development Of A Vascularized, Induced Pluripotent Stem Cell-Derived Liver-Tissue Mimic For Therapeutic Applications., Venkat Madhav Ramakrishnan
Development Of A Vascularized, Induced Pluripotent Stem Cell-Derived Liver-Tissue Mimic For Therapeutic Applications., Venkat Madhav Ramakrishnan
Electronic Theses and Dissertations
This dissertation describes the incorporation of several technologies (stem cells, gene therapy, tissue engineering and regenerative medicine) into a single project that aims to produce a liver-tissue mimic for therapeutic applications. The liver is arguably one of the most complex organs in the body. In addition to its remarkable capacity to regenerate, it performs a host of vital functions. As a result, its impairment has widespread systemic consequences. The work described herein focused on the liver in the context of cardiovascular disease and used the heritable disorder Familial Hypercholesterolemia (FH) as a clinical disease model. As (a) the only definitive …
Synthesis And Functional Evaluation Of Peptide Modified Poly (Lactic-Co-Glycolic Acid) Nanoparticles To Inhibit Porphyromonas Gingivalis Biofilm Formation., Paridhi Kalia
Electronic Theses and Dissertations
Periodontal disease is an oral inflammatory disorder that afflicts roughly 46% of the adults in the U.S. Currently, treatment of periodontal disease involves the removal of plaque from the gingival pocket (with possible antibiotic treatment) and if necessary, gingival surgery. To our knowledge, no therapeutic approach exists that promotes host-biofilm homeostasis by limiting pathogen recolonization of the oral cavity after prophylaxis or treatment. The interaction of the pathogen Porphyromonas gingivalis with commensal streptococci is critical for initiation of periodontitis and represents a target for limiting P. gingivalis colonization of the oral cavity. Previous studies showed that a synthetic peptide …
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Synthesis, Optimization, And Degradation Of A Fish Glue/Plga Polymer., Adam T. Schworer 1989-
Electronic Theses and Dissertations
Biomaterials used for tissue engineering, specifically polymers, come from either naturally occurring, like gelatin or collagen, or synthetic sources, such as polyesters. Often times, it is advantageous to combine biomaterials in order to maximize certain material properties, such as cellular adhesion and degradation. The purpose of this study is to provide direction for the synthesis, characterization, and a combination of a combination biomaterial between fish glue (FG), a natural source polymer, and poly-lactic-co-glycolic acid (PLGA), a synthetically made polyester. First, FG is characterized for molecular weight via Gel Permeation Chromatography, GPC. Two combination methods to mix FG/PLGA solutions are then …
Fibroblast-Derived Extracellular Matrix: An Alternative Cell Culture Substrate That Alters Lung Cancer Cell Line Phenotype., Michael Thomas Scherzer
Fibroblast-Derived Extracellular Matrix: An Alternative Cell Culture Substrate That Alters Lung Cancer Cell Line Phenotype., Michael Thomas Scherzer
Electronic Theses and Dissertations
Poor lung cancer survival can largely be contributed to the metastatic cells that invade and spread throughout the body. The tumor microenvironment (TME) is composed of multiple cell types, as well as non-cellular components. The TME plays a critical role in the development of metastatic cancers by providing migratory cues that change the growing tumor’s properties. The Extracellular Matrix (ECM), a main component of the TME, has been shown to change composition during tumor progression, allowing cancer cells to invade tissue and survive away from the primary cancer site. Although the ECM is well-known to influence the fate of tumor …
Development Of A Neuromusculoskeletal Computer Model In A Chondrodystrophic Dog., Gregory Russo States
Development Of A Neuromusculoskeletal Computer Model In A Chondrodystrophic Dog., Gregory Russo States
Electronic Theses and Dissertations
Intervertebral disc disease (IVDD) is a naturally occurring disease in dogs that produces a spontaneous injury to the spinal cord. IVDD is characterized by mineralization of the intervertebral disc nucleus pulposus, which reduces its load bearing capacity and results in high rates of intervertebral disc herniation (IVDH). IVDH is disproportionately present in Dachshunds compared to other breeds, affecting an estimated 1 in 5 Dachshunds during their lifetime (Levine, J. M. et al., 2011). Assessment of injury severity and recovery in animal models is generally performed using a point scale, where subjects are graded according to metrics such as pain perception, …