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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran
Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran
Doctoral Dissertations
The significance of any drugs, therapeutic proteins, or any bioactive compounds, is based not only on their effects on diseases but also on how specifically, how readily, how controllable and how prolonged their effects on the disease without having any side effects. Thus the techniques involved in the drug encapsulation and its controlled release for a longer duration of time form one of the important processes of drug reformulation. In recent years nanoparticles have created overwhelming attention for delivering drugs by nanoencapsulation. The smaller size of nanoparticles has longer circulation time and higher cellular uptake when compared with larger size …
Fabrication Of Bioactive Osteogenic Controlled-Release Systems, Cellular Platforms, And Cellular Capsules Using Layer -By -Layer Nanoassembly, Skylar Stewart-Clark
Fabrication Of Bioactive Osteogenic Controlled-Release Systems, Cellular Platforms, And Cellular Capsules Using Layer -By -Layer Nanoassembly, Skylar Stewart-Clark
Doctoral Dissertations
There is an ever-increasing awareness that the field of tissue engineering offers many potential solutions to clinical problems. While advances along these lines have been made, the design and implementation of an "off the shelf" tissue is yet to be realized. Thus, the objectives of this work were largely aimed at the design and fabrication of biocompatible, bioactive structures which could be integrated into existing biomaterial products.
The electrostatic layer-by-layer (LbL) self-assembly technique was used to incorporate biologically relevant molecules within controlled release systems, cell culture platforms, and 3-D cellular capsules. Two delivery systems were investigated to determine the release …
Application Of Polyelectrolyte Layer-By-Layer Nano-Assembly For Surface Modification, Encapsulation And Controlled Release, Nikhil Anil Pargaonkar
Application Of Polyelectrolyte Layer-By-Layer Nano-Assembly For Surface Modification, Encapsulation And Controlled Release, Nikhil Anil Pargaonkar
Doctoral Dissertations
In this study, we applied the traditional Electrostatic layer-by-layer (ELBL) assembly procedure to fabricate nanothin films over flat surfaces, and modify particle surfaces to influence the drug particle size, and drug release. The ELBL assembly has previously been applied to fabricate multilayer nano-scale thin films, but its ability to instantaneously influencing particle size is unique. Other unique observations such as influence on drug release as a result of polymer complexation, and thermal changes occurring during layer fabrication are recorded.
The ELBL self-assembly process was applied to produce dexamethasone particles layered with various polyelectrolyte layer combinations. These combinations were further applied …