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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Chemical and Biological Engineering Publications

2012

Carbohydrates

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

High-Throughput Synthesis Of Carbohydrates And Functionalization Of Polyanhydride Nanoparticles, Brenda Rocio Carrillo-Conde, Rajarshi Roychoudhury, Ana Vianey Chavez-Santoscoy, Balaji Narasimhan, Nicola L.B. Pohl Jul 2012

High-Throughput Synthesis Of Carbohydrates And Functionalization Of Polyanhydride Nanoparticles, Brenda Rocio Carrillo-Conde, Rajarshi Roychoudhury, Ana Vianey Chavez-Santoscoy, Balaji Narasimhan, Nicola L.B. Pohl

Chemical and Biological Engineering Publications

Transdisciplinary approaches involving areas such as material design, nanotechnology, chemistry, and immunology have to be utilized to rationally design efficacious vaccines carriers. Nanoparticle-based platforms can prolong the persistence of vaccine antigens, which could improve vaccine immunogenicity 1. Several biodegradable polymers have been studied as vaccine delivery vehicles 1; in particular, polyanhydride particles have demonstrated the ability to provide sustained release of stable protein antigens and to activate antigen presenting cells and modulate immune responses 2-12. The molecular design of these vaccine carriers needs to integrate the rational selection of polymer properties as well as the incorporation of appropriate targeting agents ...