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Full-Text Articles in Biomedical Engineering and Bioengineering

Modeling Of Deoxy- And Dideoxyaldohexopyranosyl Ring Puckering With Mm3(92), William M. Rockey, Michael K. Dowd, Peter J. Reilly, Alfred D. French Oct 2001

Modeling Of Deoxy- And Dideoxyaldohexopyranosyl Ring Puckering With Mm3(92), William M. Rockey, Michael K. Dowd, Peter J. Reilly, Alfred D. French

Chemical and Biological Engineering Publications

Extensive variations of the ring structures of three deoxyaldohexopyranoses, l-fucose, d-quinovose, and l-rhamnose, and four dideoxyaldohexopyranoses, d-digitoxose, abequose, paratose, and tyvelose, were studied by energy minimization with the molecular mechanics algorithm MM3(92). Chair conformers, 4C1 ind-quinovose and the equivalent 1C4 in l-fucose and l-rhamnose, overwhelmingly dominate in the three deoxyhexoses; in the d-dideoxyhexoses, 4C1 is again dominant, but with increased amounts of 1C4 forms in the α anomers of the three 3,6-dideoxyhexoses, abequose, paratose, and tyvelose and in both α and β anomers of the 2,6-dideoxyhexose d-digitoxose. In general ...


Polysaccharide Recognition By Surfactant Protein D:  Novel Interactions Of A C-Type Lectin With Nonterminal Glucosyl Residues, Martin J. Allen, Alain Laederach, Peter J. Reilly, Robert J. Mason Jul 2001

Polysaccharide Recognition By Surfactant Protein D:  Novel Interactions Of A C-Type Lectin With Nonterminal Glucosyl Residues, Martin J. Allen, Alain Laederach, Peter J. Reilly, Robert J. Mason

Chemical and Biological Engineering Publications

Surfactant protein D (SP-D), a C-type lectin, is an important pulmonary host defense molecule. Carbohydrate binding is critical to its host defense properties, but the precise polysaccharide structures recognized by the protein are unknown. SP-D binding toAspergillus fumigatus is strongly inhibited by a soluble β-(1→6)-linked but not by a soluble β-(1→3)-linked glucosyl homopolysaccharide (pustulan and laminarin, respectively), suggesting that SP-D recognizes only certain polysaccharide configurations, likely through differential binding to nonterminal glucosyl residues. In this study we have computationally docked α/β-d-glucopyranose and α/β-(1→2)-, α/β-(1→3)-, α/β- ...


Micropatterned Schwann Cell-Seeded Biodegradable Polymer Substrates Significantly Enhance Neurite Alignment And Outgrowth, Cheryl Miller, Srdija Jeftinija, Surya K. Mallapragada Jan 2001

Micropatterned Schwann Cell-Seeded Biodegradable Polymer Substrates Significantly Enhance Neurite Alignment And Outgrowth, Cheryl Miller, Srdija Jeftinija, Surya K. Mallapragada

Chemical and Biological Engineering Publications

Biomimetic strategies were employed to promote directional outgrowth of neurites in vitro by using a synergistic combination of physical, chemical, and cellular cues. Compression molded and solvent cast biodegradable polymer substrates made of poly(D,L-lactic acid) were micropatterned to form grooves on the substrate surfaces. Laminin was localized in the grooves, and rat sciatic Schwann cells were seeded on the substrates. Whole as well as dissociated rat dorsal root ganglia were seeded on the substrates along with Schwann cells, and neurite outgrowth and alignment were measured. The micropatterns provide physical guidance, laminin provides chemical cues, and the Schwann cells ...