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Development Of Poly(Lactic Acid)-Poly(Ethylene Glycol) Nanoparticles For The Delivery Of Non- Toxic Drug In Combination Therapy For The Treatment Of Glioblastoma And Neuroblastoma, Olivia Grace Decroes

All Theses

Glioblastoma and neuroblastoma are both solid-form tumors. Glioblastomas primarily reside in the brain, while neuroblastomas are found in the sympathetic nervous system. Both glioblastoma and neuroblastoma re classified as orphan diseases, which affect less than 200,000 individuals a year. Over the course of 5 years, 40% of patients diagnosed with neuroblastomas and only 6% of patients diagnosed will glioblastomas will be living.^73,74. Glioblastoma and neuroblastoma tumors possess a gene known as MGMT. MGMT is used by tumors as a DNA repair mechanism, which increases the likelihood these tumors will become resistant to traditional drug therapies.^28,37 Other pathways, …