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Articles 1 - 6 of 6
Full-Text Articles in Biomedical Engineering and Bioengineering
Influence Of Topography Of Endovascular Stent Material On Smooth Muscle Cell Response, Vipul Taneja
Influence Of Topography Of Endovascular Stent Material On Smooth Muscle Cell Response, Vipul Taneja
All Theses
Although implantation of endovascular stents for the treatment of coronary and peripheral artery diseases has been one of the most rapidly used medical interventions, significant limitations in terms of a restenosis rate of 10-30% still persists. Neointimal hyperplasia characterized by a phenotypic shift of smooth muscle cells from contractile to synthetic type, has been deemed to be the predominant cause of restenosis. A number of stent surface parameters, including topography, have been attributed to play an important role in stent performance. Although endothelial cell and thrombotic response to surface roughness have been well evaluated, the effect of topography of the …
Vena Cava As An Alternative To Pericardium In Bioprosthetic Percutaneous Heart Valves, Amy Munnelly
Vena Cava As An Alternative To Pericardium In Bioprosthetic Percutaneous Heart Valves, Amy Munnelly
All Theses
Valve disease is a specialized form of cardiovascular disease that specifically affects the heart valves. Heart valves serve the vital function of maintaining unidirectional blood flow through the chambers of the heart during the cardiac cycle; however, as valve disease progresses, this function can become severely compromised [1]. Currently, the only cure for valve disease is to replace the defective valve with an engineered substitute. Each year, over 300,000 heart valve replacement surgeries are performed worldwide [2], and this number is expected to continue growing as life expectancies increase [3].
In the United States, the most common form of valve …
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
All Theses
Valvular heart diseases lead to over 290,000 heart valve replacements worldwide each year, and approximately half of these involve replacement with a bioprosthetic heart valve (BHV) [1]. BHVs exhibit excellent hemocompatibility, but suffer from inadequate long-term durability with most adult implanted valves failing within 12 to 15 years after implantation [2]. Although this may be adequate for some individuals, BHV implantation may be contraindicated in younger individuals to avoid reoperation. Even in elder recipients, valve dysfunction can still cause death or reoperation that could be avoided with increased BHV durability. Therefore, investigation into methods of increasing BHV durability can not …
In Vitro Analysis Of Auto-Loom Woven Test Patches For Hernia Repair, Bryant Mersereau
In Vitro Analysis Of Auto-Loom Woven Test Patches For Hernia Repair, Bryant Mersereau
All Theses
Hernias are defects in the layers of the abdominal wall that can cause discomfort or pain and lead to serious health problems if left untreated. A significant portion of the world's population is afflicted by hernia formation, and the cost of treating those affected is in the billions of dollars in the US alone. The current best practices for repairing hernias involve the surgical implantation of polymeric meshes over and around the defect site. The mesh, acting as a synthetic replacement for the damaged abdominal wall layers, provides a barrier to further visceral protrusions through the defect, a support framework …
Structural Bioinformatics Based Method For Predicting The Initial Adsorbed Protein Orientation On A Surface, Aby Thyparambil
Structural Bioinformatics Based Method For Predicting The Initial Adsorbed Protein Orientation On A Surface, Aby Thyparambil
All Theses
In any molecular simulation of protein-surface interaction, the selection of the initial orientation with which the protein would interact with the surface must be first made and is found to be critical in the determination of the bioactive state of the adsorbed protein. While various molecular simulation methods have been developed to identify the preferred orientation, these methods are generally computationally expensive and time consuming, especially for large molecules thereby motivating the current study.
The computational implementation for identifying a preferred orientation was done in MATLAB¨ and directly addresses the current research problem by assuming the protein to be rigid …
Hemocompatibility And Endothelialization Of Elastin And Collagen Scaffolds: The Role Of Plasma Proteins, Shear Stress And Integrins, Nithya Swaminathan
Hemocompatibility And Endothelialization Of Elastin And Collagen Scaffolds: The Role Of Plasma Proteins, Shear Stress And Integrins, Nithya Swaminathan
All Theses
Cardiovascular diseases are the leading cause of death worldwide as reported by the World Health Organization. Biomaterials have been extensively used in blood-contacting applications as heart valves, stents, grafts and catheters. However failure due to thrombosis hinders the long term patency and potential of these devices. Purified elastin scaffolds derived from porcine arteries as potential vascular graft materials are being investigated in our laboratory. In this study, we investigated the influence of factors such as shear stress and the presence of plasma proteins on the platelet response, and endothelial cell retention on purified elastin scaffolds to evaluate their hemocompatibility.
Elastin …