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Development And Characterization Of Lung Derived Extracellular Matrix Hydrogels, Robert A. Pouliot
Development And Characterization Of Lung Derived Extracellular Matrix Hydrogels, Robert A. Pouliot
Theses and Dissertations
Chronic obstructive pulmonary disease (COPD) including emphysema is a devastating condition, increasing in prevalence in the US and worldwide. There remains no cure for COPD, rather only symptomatic treatments. Due to unique challenges of the lung, translation of therapies for acute lung injury to target chronic lung diseases like COPD has not been successful. We have been investigating lung derived extracellular matrix (ECM) hydrogels as a novel approach for delivery of cellular therapies to the pulmonary system.
During the course of this work we have developed and characterized a lug derived ECM hydrogel that exhibits “injectability,” allowing cells or dugs …