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Biomedical Engineering and Bioengineering Commons

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Articles 1 - 4 of 4

Full-Text Articles in Biomedical Engineering and Bioengineering

Mechanical Loading Attenuates Radiation-Induced Bone Loss In Bone Marrow Transplanted Mice, Peter M. Govey, Yue Zhang, Henry J. Donahue Jan 2016

Mechanical Loading Attenuates Radiation-Induced Bone Loss In Bone Marrow Transplanted Mice, Peter M. Govey, Yue Zhang, Henry J. Donahue

Biomedical Engineering Publications

Exposure of bone to ionizing radiation, as occurs during radiotherapy for some localized malignancies and blood or bone marrow cancers, as well as during space travel, incites dose-dependent bone morbidity and increased fracture risk. Rapid trabecular and endosteal bone loss reflects acutely increased osteoclastic resorption as well as decreased bone formation due to depletion of osteoprogenitors. Because of this dysregulation of bone turnover, bone’s capacity to respond to a mechanical loading stimulus in the aftermath of irradiation is unknown. We employed a mouse model of total body irradiation and bone marrow transplantation simulating treatment of hematologic cancers, hypothesizing that ...


Novel Osteogenic Ti-6al-4v Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation, David J. Cohen, A Cheng, A. Kahn, M. Aviram, Alexander J. Whitehead, Sharon Hyzy, Ryan M. Clohessy, Barbara D. Boyan, Zvi Schwartz Jan 2016

Novel Osteogenic Ti-6al-4v Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation, David J. Cohen, A Cheng, A. Kahn, M. Aviram, Alexander J. Whitehead, Sharon Hyzy, Ryan M. Clohessy, Barbara D. Boyan, Zvi Schwartz

Biomedical Engineering Publications

Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone ...


24r,25-Dihydroxyvitamin D3 Protects Against Articular Cartilage Damage Following Anterior Cruciate Ligament Transection In Male Rats, Barbara D. Boyan, Sharon L. Hyzy, Qingfen Pan, Kayla M. Scott, Richard D. Coutts, Robert Healey, Zvi Schwartz Jan 2016

24r,25-Dihydroxyvitamin D3 Protects Against Articular Cartilage Damage Following Anterior Cruciate Ligament Transection In Male Rats, Barbara D. Boyan, Sharon L. Hyzy, Qingfen Pan, Kayla M. Scott, Richard D. Coutts, Robert Healey, Zvi Schwartz

Biomedical Engineering Publications

Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25 (OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25 (OH)2D3] accumulates in articular cartilage following injection of [3 H]-25(OH)D3. Previously, we showed that 24R,25(OH)2D3 blocks chondrocyte apoptosis via phospholipase D and p53, suggesting a role for 24R,25(OH)2D3 in maintaining cartilage health. We examined the ability of 24R,25(OH)2D3 to prevent degenerative changes in articular cartilage in an OAlike environment and the potential mechanisms involved. In vitro, rat articular chondrocytes were treated with ...


Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus Jan 2016

Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus

VCU Libraries Faculty and Staff Presentations

Background

Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary Research Group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Librarians routinely attended lab meetings and shared notes with each other to monitor researcher needs.

Methods

The Informationist Team regularly provided support for literature searches, creating search alerts, bibliographic citation management and sharing, and data management to an interdisciplinary Research ...