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Biomedical Engineering and Bioengineering Commons

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Articles 1 - 6 of 6

Full-Text Articles in Biomedical Engineering and Bioengineering

Development Of An Inexpensive, Haptic Graphical Display Device, David Burch Dec 2008

Development Of An Inexpensive, Haptic Graphical Display Device, David Burch

Theses and Dissertations

A finger-worn haptic device capable of rendering 2-D graphics through vibrotactile feedback is presented. The device development is presented from its initial stages of being a stylus design using a photo-interrupter optical sensor and pager-motor actuator to a small case worn on the finger using a RGB color sensor and a piezoelectric actuator. Testing of the latest prototype design shows that it has a spatial sensitivity (<2mm) comparable to natural touch (~1mm) and can be used to output a variety of vibrotactile textures. The design can be expanded for a multiple finger, independent device, while remaining affordable (<$100) and highly portable (<500g).


Synthesis And Characterization Of Novel Temperature-Responsive Dendritic Peg-Pdlla Star Polymers For Drug Delivery, Arunvel Kailasan Nov 2008

Synthesis And Characterization Of Novel Temperature-Responsive Dendritic Peg-Pdlla Star Polymers For Drug Delivery, Arunvel Kailasan

Theses and Dissertations

This study describes a novel thermoresponsive dendritic polyethylene glycol-poly(D, L-lactide) (PEG-PDLLA) core-shell nanoparticle with potential for drug delivery and controlled release. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG to Starburstâ„¢ polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA, in which PEG chain length (i.e., MW=1500, 6000 or 12000 Dalton) was varied; however, the feeding molar ratio of DLLA monomers to the overall PEG repeat units on the dendrimer surface was kept at 1:1. Linear PEG-PDLLA copolymers were also syntheiszed under the same condition and used as control. According ...


Angiogenic Potential Of Human Macrophages On Electrospun Bioresorbable Vascular Grafts, Koyal Garg Nov 2008

Angiogenic Potential Of Human Macrophages On Electrospun Bioresorbable Vascular Grafts, Koyal Garg

Theses and Dissertations

The aim of this study was to investigate macrophage interactions with electrospun scaffolds and quantify the expression of vital angiogenic growth factors in vitro. This study will further help in evaluating the potential of these electrospun constructs as vascular grafts for tissue repair and regeneration in situ. Human peripheral blood macrophages were seeded in serum free media on electrospun (10 mm) discs of polydioxanone (PDO), elastin and PDO:elastin blends (50:50, 70:30 and 90:10). The growth factor secretion was analyzed by ELISA. Macrophages produced high levels of vascular endothelial growth factor (VEGF) and acidic fibroblast growth factor ...


Synthesis And Characterization Of Polyionic Hydrogels, Pooja Desai Jul 2008

Synthesis And Characterization Of Polyionic Hydrogels, Pooja Desai

Theses and Dissertations

In this study we describe novel polyionic dendrimer – PEG hydrogels for drug delivery. Hydrogels have a crosslinked insoluble network of polymer chains, which have found many applications including drug delivery and tissue regeneration. Dendrimers provide an ideal platform for drug delivery as they possess a well-defined highly branched nanoscale architecture with many reactive surface groups. Their highly clustered surface groups allow for targeted drug delivery and high drug payload to enhance therapeutic effectiveness. This study presented a new type of polyionic hydrogels based on dendrimers with potential applications in drug delivery and tissue engineering. Polyethylene glycol (PEG) with various chain ...


Balance Performance Measurment In A Phase Shifted Feedback Environment, Craig Alan Hoovler Jan 2008

Balance Performance Measurment In A Phase Shifted Feedback Environment, Craig Alan Hoovler

Theses and Dissertations

Commercial technologies for the objective assessment of balance exist in clinical settings. Training requires integration of sensory information to produce a coordinated motor response related to balance. These systems have had measurable phase delays of up to 250ms in the visual feedback provided to the patient. This provokes an unnatural response, requiring prediction from the subject. The proposed research investigates the impact of visual feedback phase delays on the performance of weight shift tracking tasks in a population of individuals with no known balance deficits.Visual feedback delays were investigated by simulating popular balance training software which utilizes force plates ...


Electromyographic Characterization In An Animal Model Of Dystonia, Kunal Dilip Chaniary Jan 2008

Electromyographic Characterization In An Animal Model Of Dystonia, Kunal Dilip Chaniary

Theses and Dissertations

Kernicterus causes damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin neurotoxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. Electromyographic (EMG) activity was recorded from antagonistic hip muscles in dystonic and in normal appearing rats. Raw EMG signals were decomposed using the Discrete Wavelet Transform based multi-resolution ...