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Biomedical Engineering and Bioengineering Commons™
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- Electrospinning (2)
- 3D printing (1)
- Biosensor (1)
- Buccal (1)
- Combination therapy (1)
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- Core-shell composite particles (1)
- Dendrimer (1)
- Dermal scaffold (1)
- Drug Delivery (1)
- E-beam lithography (1)
- Electrospray (1)
- Electrospray deposition (1)
- Extracellular matrix (1)
- IL-33 (1)
- Lactic acid (1)
- Mast cells (1)
- MiR-155 (1)
- Nanofibers (1)
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- Ocular (1)
- Photolithography (1)
- Polydioxanone (1)
- Polyglycolic acid (1)
- Pro-regenerative macrophages (1)
- Protein nanoparticles (1)
- Sequential release (1)
- Silk proteins (1)
- Silk-optics (1)
- Stem cell delivery (1)
- Supercapacitor (1)
Articles 1 - 6 of 6
Full-Text Articles in Biomedical Engineering and Bioengineering
Modulating The Innate Immune Response To Electrospun Scaffolds And Polymer Degradative Byproducts, Daniel Abebayehu
Modulating The Innate Immune Response To Electrospun Scaffolds And Polymer Degradative Byproducts, Daniel Abebayehu
Theses and Dissertations
Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It is critical to determine how to modulate the response of tissue resident innate immune cells, as they are among the first cells to interact with implanted materials. Among tissue resident innate immune cells are mast cells, which are inflammatory sentinels that degranulate and orchestrate the fate of other cell populations, such as monocytes/macrophages and lymphocytes. Mast cells have also been reported to …
Investigation Of Polymeric Composites For Controlled Drug Release, Hsi-Wei Yeh
Investigation Of Polymeric Composites For Controlled Drug Release, Hsi-Wei Yeh
Theses and Dissertations
The Electrospray (ES) technique is a promising particle generation method for drug delivery due to its capabilities of producing monodisperse PLGA composite particles with unique configurations and high drug encapsulation efficiency. In the dissertation work, the coaxial dual capillary ES was used to generate drug-loaded core-shell PLGA particles to study the effects of particle filling materials, drug loading locations and particle shell thicknesses on the resultant in vitro release behaviors of the hydrophilic and/ or hydrophobic model drugs. Through release profile characterization of drug-loaded PLGA particles (particle size: 400 nm and 1 μm), it was confirmed that the co-encapsulation of …
Fabrication Of Flexible, Biofunctional Architectures From Silk Proteins, Ramendra K. Pal
Fabrication Of Flexible, Biofunctional Architectures From Silk Proteins, Ramendra K. Pal
Theses and Dissertations
Advances in the biomedical field require functional materials and processes that can lead to devices that are biocompatible, and biodegradable while maintaining high performance and mechanical conformability. In this context, a current shift in focus is towards natural polymers as not only the structural but also functional components of such devices. This poses material-specific functionalization and fabrication related questions in the design and fabrication of such systems. Silk protein biopolymers from the silkworm show tremendous promise in this regard due to intrinsic properties: mechanical performance, optical transparency, biocompatibility, biodegradability, processability, and the ability to entrap and stabilize biomolecules. The unique …
Nanomedicine Drug Delivery Across Mucous Membranes, Michael G. Lancina Iii
Nanomedicine Drug Delivery Across Mucous Membranes, Michael G. Lancina Iii
Theses and Dissertations
NANOMEDECINE DRUG DELIVERY ACROSS MUCOUS MEMBRANES
By Michael G. Lancina III
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.
Virginia Commonwealth Univeristy, 2017.
Major Director: Dr. Hu Yang, Associate Professor, Chemical and Life Science Engineering
Control over the distribution of therapeutic compounds is a complex and somewhat overlooked field of pharmaceutical research. When swallowing a pill or receiving an injection, it is commonly assumed that drug will spread throughout the body in a more or less uniform concentration and find its way to wherever it is needed. In …
Electrospraying Extracellular Matrix To Form Nanoparticles, Patrick Link
Electrospraying Extracellular Matrix To Form Nanoparticles, Patrick Link
Theses and Dissertations
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide. Alveolar wall destruction is a significant contributor to COPD. Inflammatory macrophages are a major source of the Extracellular Matrix (ECM) proteolysis. ECM breakdown causes air to get trapped in the alveoli, obstructing airflow. One step in curing COPD may be to convert inflammatory to pro-regenerative macrophages. Recently, decellularized ECM scaffolds have shown the ability to induce a pro-regenerative phenotype.
Yet these scaffolds are incapable for reaching the alveolar region of the lungs. To reach the alveolar region particles need a diameter of 1-5 μm or smaller than 300 …
Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing, Ryan M. Clohessy
Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing, Ryan M. Clohessy
Theses and Dissertations
The goal of this research was to develop a system of individualized medicine that could be applied to dermal wounds serving as a wound dressing and synthetic extracellular matrix while delivering stem cells to the wound bed. First, fabrication parameters for electrospinning polymer fibers were determined. This involved evaluating fiber morphology with respect to polymer selection and solution concentration. Next, construct fabrication was examined to produce an integrated void space, or cargo area, suitable to maintain stem cells. In vitro studies to ensure stem cell viability and phenotype were conducted, and results supported the notion that cells could be administered …