Biomedical Engineering and Bioengineering Commons^™

Dynamics, Electromyography And Vibroarthrography As Non-Invasive Diagnostic Tools: Investigation Of The Patellofemoral Joint, Filip Leszko

Doctoral Dissertations

The knee joint plays an essential role in the human musculoskeletal system. It has evolved to withstand extreme loading conditions, while providing almost frictionless joint movement. However, its performance may be disrupted by disease, anatomical deformities, soft tissue imbalance or injury. Knee disorders are often puzzling, and accurate diagnosis may be challenging. Current evaluation approach is usually limited to a detailed interview with the patient, careful physical examination and radiographic imaging. The X-ray screening may reveal bone degeneration, but does not carry sufficient information of the soft tissue conditions. More advanced imaging tools such as MRI or CT are available, …

Applications Of Nanoparticle Image Velocimetry In Nanofluids, Sara Salim Haque

Masters Theses

Particle Image Velocimetry (PIV) is an optical technique used for the visualization of fluid flow. PIV can be combined with other techniques to enhance the analysis of fluid flow. A novel far-field plasmonic resonance enhanced nanoparticle-seeded Particle Image Velocimetry (nPIV) has been demonstrated to measure the velocity in a micro channel. Chemically synthesized silver nanoparticles have been used to seed the flow. By using Discrete Dipole Approximation (DDA), plasmonic resonance enhanced light scattering has been calculated for spherical silver nanoparticles with diameters ranging from 15 nm to 200 nm in two media: water and air. The diffraction-limited plasmonic resonance enhanced …

Seasonal Initial Concentrations And In-Field Decay Rates Of Escherichia Coli And Bovine Bacteroidetes In Beef Cattle Manure, Jiangwei Liu

Masters Theses

Eight naturally deposited beef cow manure patties were sampled during summer (July 19 to August 9, 2010), fall (October 26 to November 19, 2010), winter (January 14 to February 18, 2011), and spring (May 5-27, 2011) to determine whether hypothesized seasonal differences existed in the initial concentrations and decay rates of Escherichia coli (E. coli) and bovine Bacteroidetes (BoBac). E. coli concentrations were estimated as culturable colony forming units (CFU) and with a quantitative polymerase chain reaction (qPCR) assay targeting the 23S ribosomal gene. BoBac was quantified with a qPCR assay targeting a 16S ribosomal gene sequence associated …

Positron Emission Tomography (Pet) For Flow Measurement, Bi Yao Zhang

Masters Theses

Positron Emission Tomography (PET) is frequently used for medical imaging. Maturity and flexibility of PET as an imaging technique has expanded its utility beyond the medical domain. It can be used as a tool for fluid flow studies in opaque fluids and for flow within complex geometry where conventional optical flow measurement approaches fail. This study explores the capabilities of PET as flow measurement tool suited to validation of computational fluid dynamic (CFD) predictions.

The MicroPET P4 scanner was used to image the diffusion process in flow around a rod bundle geometry similar to that found in a nuclear reactor …

Modeling Of Human Hand Motion In A Maya Environment, Andrew M. Quinn, Aeshan Ali, Tessa Taylor, Quincy Beasley

Chancellor’s Honors Program Projects

No abstract provided.

Feasibility Of A Touch Sensitive Breast Phantom For Use In The Training Of Physicians In Clinical Breast Examination, Corinne Ashlie Davis, Katherine Lynn Mittura, Grace Elizabeth Copeland, Erica Martina Hawkins

Chancellor’s Honors Program Projects

No abstract provided.

Synthesis And Characterization Of Diamond-Like Carbon Thin Films For Biomedical Applications, Russell Lee Leonard

Masters Theses

Diamond-like carbon (DLC) thin films were produced by pulsed laser deposition (PLD) on silicon, fused silica, and silicon nitride substrates. The films produced were either undoped, made using a pure graphite target, or doped, using multi-component targets made from a combination of graphite and silicon, silicon nitride, titanium dioxide, or silicon monoxide. These films were evaluated for their potential use in biomedical applications, including coatings for artificial joints, heart stents, and bronchoscopes. The films were characterized by Raman spectroscopy, atomic force microscopy, ball-on-flat tribometry, contact angle measurements, and spectrophotometry. Film thickness was determined by optical profilometry. Film adhesion was checked …

Polymeric Microsensors For Intraoperative Contact Pressure Measurement, Emily R. Pritchard

Doctoral Dissertations

Biocompatible sensors have been demonstrated using traditional microfabrication techniques modified for polymer substrates and utilize only materials suitable for implantation or bodily contact. Sensor arrays for the measurement of the load condition of polyethylene spacers in the total knee arthroplasty (TKA) prosthesis have been developed. Arrays of capacitive sensors are used to determine the three-dimensional strain within the polyethylene prosthesis component. Data from these sensors can be used to give researchers a better understanding of component motion, loading, and wear phenomena for a large range of activities. This dissertation demonstrates both analytically and experimentally the fabrication of these sensor arrays …

Developing Chitosan-Based Biomaterials For Brain Repair And Neuroprosthetics, Zheng Cao

Masters Theses

Chitosan is widely investigated for biomedical applications due to its excellent properties, such as biocompatibility, biodegradability, bioadhesivity, antibacterial, etc. In the field of neural engineering, it has been extensively studied in forms of film and hydrogel, and has been used as scaffolds for nerve regeneration in the peripheral nervous system and spinal cord. One of the main issues in neural engineering is the incapability of neuron to attach on biomaterials. The present study, from a new aspect, aims to take advantage of the bio-adhesive property of chitosan to develop chitosan-based materials for neural engineering, specifically in the fields of brain …

Identification And Quantification Of Cotton Yield Monitor Errors, Jason Clay Head

Masters Theses

Cotton yield monitors are an important part of a precision agriculture program and are becoming widely used by cotton producers for making management decisions. Members of the cotton industry have shown interest in using cotton yield monitors for collecting data from production scale variety yield trials (experiments that test yield performance for numerous varieties). Weighing boll buggies are the current industry standard for measuring yield in variety trials. This process is time consuming and requires extra equipment and labor. The ability to use a yield monitor for measuring yield would streamline variety trial harvesting. Recommendations for the Ag Leader cotton …

Vibration Analysis Of Heavy-Duty Diesel Vehicles, Christopher Jack Campbell

Masters Theses

Truck drivers are more susceptible than other workers to lower back pain and spinal disorders caused by whole body vibrations, which are among the most common long term health effects for drivers. The dynamic behavior of trucks can be modeled and simulated to improve the design of the trucks, which can reduce the exposure of drivers to whole body vibrations.

The main purposes of this study are to analyze vibrations for different manufacturers and road types, and to create a computer-based model using Adams to predict vibration anywhere on the model using acceleration data collected previously from on-road tests of …

Insight Into The Gating Mechanism Of Mechanosensitive Ion Channels Using A Simple Structure: A Step In The Analysis Of Commotio Cordis, Sumeet Kaul

Masters Theses

Mechanosensation in cells is a well known phenomenon that is associated with cellular responses to force. Our knowledge of the trigger mechanism of this phenomenon is, however, limited. Earlier studies in this field have used atomic simulations, which although being accurate, are limited in their feasibility in multi-length scenarios like a mechanosensitive channel that undergoes micro-level changes in the composition of the protein to cause a macro-level change in the state of a biological structure such as the muscle. Finite Element Analysis has been used in various engineering fields to study the mechanical response of complex structures. The current study …

Controlling Accumulation Of Fermentation Inhibitors In Biorefinery Recycle Water Using Microbial Fuel Cells, Abhijeet P. Borole, Jonathan R. Mielenz, Tatiana A. Vishnivetskaya, Choo Y. Hamilton

Faculty Publications and Other Works -- Chemical and Biomolecular Engineering

Background

Microbial fuel cells (MFC) and microbial electrolysis cells are electrical devices that treat water using microorganisms and convert soluble organic matter into electricity and hydrogen, respectively. Emerging cellulosic biorefineries are expected to use large amounts of water during production of ethanol. Pretreatment of cellulosic biomass results in production of fermentation inhibitors which accumulate in process water and make the water recycle process difficult. Use of MFCs to remove the inhibitory sugar and lignin degradation products from recycle water is investigated in this study.

Results

Use of an MFC to reduce the levels of furfural, 5-hydroxymethylfurfural, vanillic acid, 4-hydroxybenzaldehyde and …

A Shooting Algorithm For Complex Immunodominance Control Problems, Xiaopeng Zhao, R Yang, M Zhang

Faculty Publications and Other Works -- Mechanical, Aerospace and Biomedical Engineering

Although T cells are able to recognize a wide variety of target peptides, they are often strongly focused on a few of the peptides and leave the rest of them unattended. This phenomenon of strongly biased immune response is known as immunodominance. Mathematically, an immunodominance problem can be formulated using optimal control principles as a two-point boundary-value problem. The solution of this problem is challenging especially when the control variables are bounded. In this work, we develop a numerical algorithm based on the shooting technique for bounded optimal control problems. The algorithm is applied to a group of immunodominance problems. …

Development Of A Computational Model To Predict The In Vivo Contact Mechanics Of Modern Total Knee Arthroplasty, Adrija Sharma

Doctoral Dissertations

This dissertation focuses on the development of a computationally efficient and fast method that incorporates the kinematics obtained from fluoroscopy and extends it to the prediction of the in-vivo contact mechanics at the femoro-tibial articulation in modern knee implants for the deep knee bend activity. In this endeavor, this dissertation deals with the use of an inverse dynamic rigid body model characterizing the slip and roll behavior observed in the femoro-polyethylene articulation and a coupled deformation model where the polyethylene in knee implants are modeled as hexahedral discrete element networks. The performance of this method is tested by comparing force …

The Future Of The Operating Room: Surgical Preplanning And Navigation Using High Accuracy Ultra-Wideband Positioning And Advanced Bone Measurement, Brandon C. Merkl

Doctoral Dissertations

This dissertation embodies the diversity and creativity of my research, of which much has been peer-reviewed, published in archival quality journals, and presented nationally and internationally. Portions of the work described herein have been published in the fields of image processing, forensic anthropology, physical anthropology, biomedical engineering, clinical orthopedics, and microwave engineering.

The problem studied is primarily that of developing the tools and technologies for a next-generation surgical navigation system. The discussion focuses on the underlying technologies of a novel microwave positioning subsystem and a bone analysis subsystem. The methodologies behind each of these technologies are presented in the context …

Synergistic Effect Of Retinoic Acid, Nerve Growth Factor And Laminin For Enhanced Neurite Extension, Shrarath Ashwin Sriman

Masters Theses

Peripheral Nerve Injury is one of the most common and serious traumatic injuries. About 300,000 cases of peripheral nerve injury are reported annually in Europe and another 50,000 procedures performed annually in the United States. Peripheral nerve injury can lead to lifelong disability and also death in severe cases. Repair techniques remain a major challenge because of lack of efficient regeneration. Though techniques like autografts are highly efficient, they face a lot of drawbacks. Alternate methods focus on the use of growth supporting and enhancement components in nerve guidance channels. Current research necessitates the use of a combination of compounds …

Flow And Transport In Unsaturated Porous Media: Fractal Modeling, Analytical Solutions And Experimentation, Abdullah Cihan

Doctoral Dissertations

This dissertation consists of five parts, each describing a specific topic of unsaturated flow and transport. The first three parts describe the development of soil hydraulic function models with the effects of partial drainage by using fractal and probabilistic approaches. During drainage of a porous medium, both the pore size distribution and the connectivity of pores determine the drained pore volume as function of suction. New analytical expressions were presented for the water retention (part 1), intrinsic permeability (part 2), and relative permeability (part 3) functions. Predictions based on the analytical models are compared with estimates of the intrinsic permeability …

A Study Of Irrigation, Fertigation And Plasticulture In Burley Tobacco, With A Focus On Yield, Quality And Tsna Reduction, Eric F. Caldwell

Masters Theses

Nitrogen fertilization is important in attaining high yielding, quality tobacco. However, practices that use excessive N can be uneconomical, threaten the environment and produce leaves that are high in nitrates. Leaves high in nitrates have been positively correlated with leaves that are high in tobacco specific nitrosamines (TSNA), which are considered potent carcinogens. Competition from cheaper, foreign leaf, increasing costs of fertilizers and new market structures which show purchasers seeking low TSNA leaf demand that producers become more efficient in their N use. The objective of this study is an examination of burley (TN 90) and dark (KY 171) tobacco …

Ultra-Wideband Frequency Surgical Navigation Probe, Stuart J. Deaderick

Chancellor’s Honors Program Projects

No abstract provided.

Mems Capacitive Strain Sensing Elements For Integrated Total Knee Arthroplasty Prosthesis Monitoring, Boyd Mccutchen Evans Iii

Doctoral Dissertations

Measuring the in vivo load state of Total Knee Arthroplasty (TKA) components is required to understand the structural environment and wear characteristics of the devices. The ability to acquire this information gives tremendous insight into the mechanics of the joint replacement prosthesis. Data corresponding to normal loads, in-plane loads, shear loads, load center, contact area, and the rate of loading is needed to fully understand the kinematics and kinetics of the orthopedic implant. In this research, a novel sensing system has been developed which is capable of fully characterizing three-dimensional strain and stress at a single location.

Capacitance-based sensors were …

Theoretical Modeling And Experimental Validation Of In Vivo Mechanics For Subjects Having Variable Cervical Spine Conditions, Fei Liu

Doctoral Dissertations

The objective of this study was to use the state-of-art 3D-to-2D registration technologies including fluoroscopic, CT and MRI methods to analyze 2D and 3D in vivo kinematics of the whole cervical spine under variable conditions; and use inverse dynamic model based on Kane’s dynamics to predict their 2D and 3D in vivo interactive contact and muscular forces. Totally, forty patients (ten having normal cervical spines, ten having degenerative cervical spines, ten having anterior cervical decompression and fusion (ACDF), and ten having cervical artificial disc replacement (CADR)) were enrolled into 2D study and three patients (one having normal cervical spines, one …

Characterization Of A Biomimetic Calcium-Deficient Hydroxyapatite-Bacterial Cellulose Composite, Stacy Hutchens

Doctoral Dissertations

Bone is the second most implanted tissue next to blood causing approximately 2.2 million people to receive bone grafts each year. Developing safe synthetic bone grafts allows quick and safe restoration of bone function while avoiding the surgical risks associated with bone autografting (self donation), and risks of disease transmission and immunogenic response associated with allografts (bone donated from other humans) and xenografts (grafts derived from animal tissue). This dissertation entails the study and development of a novel potential synthetic bone graft consisting of a composite of calcium-deficient hydroxyapatite (CdHAP) biomimetically deposited in a bacterial cellulose (BC) hydrogel.

To determine …

Applied Fourier Transform Near-Infrared Techniques For Biomass Compositional Analysis, Lu Liu

Masters Theses

A new method for rapid chemical analysis of lignocellulosic biomass was developed using Fourier transform near-infrared (FT-NIR) spectroscopic techniques. The new method is less time-consuming and expensive than traditional wet chemistry. A mathematical model correlated FT-NIR spectra with concentrations determined by wet chemistry. Chemical compositions of corn stover and switchgrass were evaluated in terms of glucose, xylose, galactose, arabinose, mannose, lignin, and ash. Model development evaluated multivariate regressions, spectral transform algorithms, and spectral pretreatments and selected partial least squares regression, log(1/R), and extended multiplicative signal correction, respectively. Chemical composition results indicated greater variability in corn stover than switchgrass, especially among …

Image And Sieve Analysis Of Biomass Particle Sizes And Separation After Size Reduction, Yuechuan Yang

Masters Theses

Improved physical separation of biomass concentrates higher-value components, returns unused plant components to the soil, and provides a more efficient platform for downstream industrial users. Sieving and Image Analysis (IA) were studied to evaluate biomass particle sizes, particle size distribution, and potential separation of biomass materials. Switchgrass, wheat straw, and corn stover were used in the study. Particles prepared by a knife mill equipped with various screen sizes were subject to sieving test and IA. Results showed that all three biomass materials would be analyzed using the fast, easy and accurate IA. Biomass particle physical properties, such as length, width, …

Development Of The Telemetrical Intraoperative Soft Tissue Tension Monitoring System In Total Knee Replacement With Mems And Asic Technologies, Gary To

Masters Theses

The alignment of the femoral and tibial components of the Total Knee Arthoplasty (TKA) is one of the most important factors to implant survivorship. Hence, numerous ligament balancing techniques and devices have been developed in order to accurately balance the knee intra-operatively. Spacer block, tensioner and tram adapter are instruments that allow surgeons to qualitatively balance the flexion and extension gaps during TKA. However, even with these instruments, the surgical procedure still relies on the skill and experience of the surgeon. The objective of this thesis is to develop a computerized surgical instrument that can acquire intra-operative data telemetrically for …

Design And Evaluation Of A Non-Intrusive Corn Population Sensor, Haizhou Li

Doctoral Dissertations

Specific objectives of this study were to develop, prototype, and test a corn population sensor. Both intrusive mechanical and non-intrusive capacitive techniques have been used to develop the stalk population sensors in previous research. However, neither could generate consistent performance. The mechanical method required high maintenance and resulted in significant underestimations of stalk counts. The performance of capacitive systems was limited by inadequate sensing distance, especially at low stalk moisture levels.

In this research, the sensitivity of the capacitive sensor was optimized for corn stalks. This system utilized a single-sided capacitive sensor, Wien bridge oscillator, phase-locked loop, and an operational …

Risk Analysis Of Decentralized Wastewater Design Flows, Patrick Andrew Dobbs

Masters Theses

Decentralized wastewater treatment systems are often designed at flows of either 284 L/person/d (75 gal/person/d) or 568 L/bedroom/d (150 gal/bedroom/d). Water use data suggest that designing systems at these flow rates can lead to overly conservative designs. A study quantifying the risk of failure (exceeding a system design flow) was needed to create a design basis for future systems. The objectives of the study were to quantify the risk of failure of decentralized system design flows depending on the number of residences served by a system and to develop new guidelines for design flows of cluster systems based on quantifiable …

A Simulation Model For Predicting Surface Tension In Condensate Films, Allison Dawn Lewis

Masters Theses

The thesis presents a mathematical model for predicting surface tension in condensate films. The approach taken to this study is different from how surface tension is normally approached. Surface tension is primarily determined through laboratory measurements. This work shows how it can be determined mathematically based on the formulation of bonding energy between atoms as described by the Lennard-Jones potential.

The results are used to predict the surface tension of a selected group of elements and molecules. Predictions from the model compare favorably with the documented surface tension values of the selected elements. However, the model does deviate somewhat from …

Utilizing An Ultrasonic Device To Model The Lumbar Spine While Driving A Tractor Trailer, Gretchen Marie Hinton

Masters Theses

Low back pain is a common occupational effect of the long term driving of vehicles. The sonoSens® Monitor ultrasonic device was utilized to model lumbar spinal motions while driving a tractor trailer. Further data was collected to determine if acceleration from a seat pad and EMG data correlated with the driver’s movements.

Three testing bouts were completed and analyzed for this study. For each test the driver drove a 1998 Peterbuilt 379 fitted with a National Seating 2000 seat. One driver was used for all three tests.

Data analysis was accomplished with the sonoSens® Analyzer and Microsoft® Excel software. The …