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Full-Text Articles in Biomedical Engineering and Bioengineering

Engineering Success On The Field: A Reflection On The Epics Ironman Pediatric Prosthetic Project, Glynn Gallaway Nov 2018

Engineering Success On The Field: A Reflection On The Epics Ironman Pediatric Prosthetic Project, Glynn Gallaway

Purdue Journal of Service-Learning and International Engagement

Glynn Gallaway is a student in the Purdue Mechanical Engineering Class of 2020 with interests in the health care, assistive technology, and medical device industries. Glynn is from Dallas, Texas, and was inspired to pursue this career path through her interactions with youth with special needs. She joined the EPICS Ironman team in the fall of 2016 during her first year at Purdue as a part of the learning community. In this article, she discusses her experiences on the Ironman team creating a pediatric prosthetic for a young local athlete. The goal of the Ironman team is to create a ...


Magnetically Actuated Cell Stretching Platform To Induce Phenotypic Changes In Metastatic Cells, Yong Gyun Cho, Hyunsu Park, Hyowon Lee, Sarah Libring Aug 2018

Magnetically Actuated Cell Stretching Platform To Induce Phenotypic Changes In Metastatic Cells, Yong Gyun Cho, Hyunsu Park, Hyowon Lee, Sarah Libring

The Summer Undergraduate Research Fellowship (SURF) Symposium

Although metastasis is responsible for about 90% of cancer deaths, only few in vitro models can be used to evaluate dynamic behaviors of metastatic cancer cells. Many studies have shown that mechanical stimuli can trigger various cellular responses such as gene and protein expression, which could lead to changes in cellular phenotype. Similarly, metastasized breast cancer cells in the lung tissue are constantly stretched by cyclic mechanical stress due to breathing, which alters cellular morphology and proliferation state. Such transitions can make the secondary tumors resistant to the chemotherapy used to effectively treat the primary tumors. In this work, we ...


Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala Aug 2018

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to develop ...


Design Modifications For A Small, Affordable Low Intensity Focused Ultrasound Device, Sui Shen, Kelsey C. Bayer, Pedro P. Irazoqui Aug 2018

Design Modifications For A Small, Affordable Low Intensity Focused Ultrasound Device, Sui Shen, Kelsey C. Bayer, Pedro P. Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Depression is a prevalent and serious medical illness, and while there are antidepressant drugs to mitigate depressive symptoms, 10 - 30% of patients either do not respond or develop a tolerance to these medications. Literature supports that there is an interrelation between the inflammatory response and treatment-resistant depression. A promising method to tackle depressive symptoms is to block the inflammatory signaling pathway with vagus nerve stimulation (VNS), reducing pro-inflammatory cytokine levels. Although electrical VNS devices exist, they are invasive, expensive, and have side effects including voice alteration, dyspnea, and cough. Low intensity focused ultrasound (LIFU) is a promising method that can ...


Non-Invasive Diagnostic Measures Of Sensorineural Hearing Loss In Chinchillas, Hannah M. Ginsberg, Satyabrata Parida, Michael G. Heinz Aug 2018

Non-Invasive Diagnostic Measures Of Sensorineural Hearing Loss In Chinchillas, Hannah M. Ginsberg, Satyabrata Parida, Michael G. Heinz

The Summer Undergraduate Research Fellowship (SURF) Symposium

According to the World Health Organization, disabling hearing loss affects nearly 466 million people worldwide. Sensorineural hearing loss (SNHL), which is characterized as damage to the inner ear (e.g., cochlear hair cells) and/or to the neural pathways connecting the inner ear and brain, accounts for 90% of all disabling hearing loss. More concerning is that significant perceptual and physiological aspects of SNHL remain “hidden” from standard clinical diagnostics. Hidden hearing loss (HHL) manifests as the inability to understand speech in loud, noisy environments (e.g., listening in a noisy restaurant) despite a normal audiogram (i.e., normal detection ...


Thin Film Cocaine Sensors, Datta Sheregar, Vick Hung, Jenna Walker, Orlando Hoilett, Jacqueline Linnes, Robert Nawrocki Aug 2018

Thin Film Cocaine Sensors, Datta Sheregar, Vick Hung, Jenna Walker, Orlando Hoilett, Jacqueline Linnes, Robert Nawrocki

The Summer Undergraduate Research Fellowship (SURF) Symposium

Over 7 million Americans suffer from a drug use disorder and up to 60% of individuals treated for addiction will ultimately relapse. We are developing ultra-thin film electrodes on a wearable substrate for a sensor that can detect minute amounts of cocaine in sweat droplets secreted from the skin. This will enable wearable drug monitoring for personalized rehabilitation treatment plans and improve long-term addiction recovery rates. The current research focuses on developing a thin-film sensor that can be applied directly to the skin. First a layer of PVP (poly4-vinylphenol) was prepared and then spun coated onto a piece of glass ...


Low Power, Low Noise Circuit For Biological Signal Recording, Rachael A. Swenson, Daniel J. Pederson, Pedro Irazoqui Aug 2017

Low Power, Low Noise Circuit For Biological Signal Recording, Rachael A. Swenson, Daniel J. Pederson, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Implantable devices are ideal for recording biological signals in animal models as they have minimal effect on the animal’s normal behavior during observation. The creation of the circuitry for an implantable device has several restrictions including size, power consumption, and noise reduction. These factors compete against each other, making it necessary to carefully optimize circuit components for a given application. This study evaluates the design of a four-channel analog front end circuit board to record cardiac, neural, and respiratory biological signals. Through a critical analysis of component specifications for the circuit’s components and an evaluation of the circuits ...


Co-Modulation Masking Release Begins In The Auditory Periphery, Kareem R. Hussein, Agudemu Borjigan, Mark Sayles Aug 2017

Co-Modulation Masking Release Begins In The Auditory Periphery, Kareem R. Hussein, Agudemu Borjigan, Mark Sayles

The Summer Undergraduate Research Fellowship (SURF) Symposium

Understanding speech in noisy environments can be difficult, especially for people with hearing loss. The background noise can cover up the sounds of interest. Normally, the auditory system works to alleviate this problem by tagging and then cancelling the noise. Our experiments are aimed at understanding the mechanism of this noise cancellation process. We hypothesize that non-linear signal processing in the mammalian cochlea (the most peripheral part of the auditory system) is the basis of noise cancellation. To test this hypothesis, we measured the responses of auditory-nerve fibers (ANFs) to sounds embedded in background noise with different statistical properties. ANFs ...


Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu Aug 2017

Gui For Mri-Compatible Neural Stimulator And Recorder, Soo Han Soon, Nishant Babaria, Ranajay Mandal, Zhongming Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are useful tools to analyze brain activities given active stimulation. However, the electromagnetic noise from the MRI distorts the brain signal recording and damages the subject with excessive heat generated on the electrodes attached to the skin. MRI-compatible recording and stimulation systems previously developed at LIBI lab were capable of removing the electromagnetic noise during the imaging process. Previously, the hardware systems had required the integrative software that could control both circuits simultaneously and enable users to easily change recording and stimulation parameters. Graphical user interface (GUI) programmed with computer language informed ...


Pathogenic Dna Detection Using Dna Hairpins: A Non-Linear Hybridization Chain Reaction Platform, Lance Novak, Tamara L. Kinzer-Ursem Aug 2017

Pathogenic Dna Detection Using Dna Hairpins: A Non-Linear Hybridization Chain Reaction Platform, Lance Novak, Tamara L. Kinzer-Ursem

The Summer Undergraduate Research Fellowship (SURF) Symposium

Currently, 3.2 billion people are at risk of being infected with malaria, with 1.2 billion of those being at high risk (>1 in 1000 chance of getting malaria in a year). Thus, there is a need for a biosensor that is highly sensitive, cost effective, and simple to use for point-of-care diagnosis. The biosensing platform, PathVis, has achieved this by measuring changes in fluid properties after a loop-mediated isothermal amplification (LAMP). LAMP is a DNA amplification system that requires enzymes and a temperature of 65degrees C. LAMP currently limits PathVis by being costly, requiring refrigeration, and difficult to ...


A Chronically Implanted, Continuous Ph Monitoring System For Rats, Ryan B. Budde, Pedro P. Irazoqui Aug 2017

A Chronically Implanted, Continuous Ph Monitoring System For Rats, Ryan B. Budde, Pedro P. Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Many body systems operate within a strict pH range, and any deviation can cause harm. pH measurement systems are used in many biomedical research fields. Measurement systems have been able to continuously record pH for a short period of time wirelessly, or over a long period of time with wires, but no system is currently capable of long term, wireless, continuous pH recording. This paper proposes a new pH measurement system that is capable of such measurement. The system is composed of inexpensive, micro-scale, and easy to manufacture pH sensitive and reference electrodes and a data acquisition and transmission module ...


Localized Blood Occlusion Generation In An In-Vitro Circulatory Catheter System, Ryan D. Harris, Qi Yang, Hyowon Lee Aug 2017

Localized Blood Occlusion Generation In An In-Vitro Circulatory Catheter System, Ryan D. Harris, Qi Yang, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hydrocephalus is a debilitating neurological disorder that involves the accumulation of cerebrospinal fluid in a ventricle of the brain. The implantation of a catheter commonly treats hydrocephalus with drainage. These catheters have a short lifespan due to obstruction from biological materials. Shunt systems have an extremely high failure rate of more than 40% failed within 1 year and up to 85% failed within 10 years. Previously, polymer-based flexible implantable magnetic micro-actuators were developed to clean up the catheter by mechanical vibration. We have demonstrated clearing of bacteria attachment and are proceeding to examine clearing effects on larger clotting materials, such ...


Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang Oct 2016

Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee Aug 2016

Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term ...


Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa Aug 2016

Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa

The Summer Undergraduate Research Fellowship (SURF) Symposium

Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known ...


Lipid Detection In Pig Arteries Using Intravascular Photoacoustic Imaging, Jieying Mai, Yingchun Cao, Ayeeshik Kole, Michael Sturek, Ji-Xin Cheng Aug 2016

Lipid Detection In Pig Arteries Using Intravascular Photoacoustic Imaging, Jieying Mai, Yingchun Cao, Ayeeshik Kole, Michael Sturek, Ji-Xin Cheng

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart disease is the leading cause of death in the United States and worldwide. Each year over 370,000 people died from coronary artery disease in America. As the primary form of coronary artery disease, atherosclerosis behaves as lipid-rich plaque development inside an artery wall. Vulnerable plaques are those prone to rupture, which may result in thrombus or even death. Typical hallmarks of a vulnerable plaque include thin fibrous cap, a large lipid-rich necrotic core and inflammatory infiltrate. The identification and accurate detection of these lipid depositions in the arterial wall is crucial in the diagnosis of atherosclerosis. However, none ...


A Proposal For A Wirelessly Powered, Implantable Pressure Sensor And Neural Stimulator For The Control Of Urinary Incontinence, Robert N. Tucker, Christopher J. Quinkert, Pedro P. Irazoqui Aug 2016

A Proposal For A Wirelessly Powered, Implantable Pressure Sensor And Neural Stimulator For The Control Of Urinary Incontinence, Robert N. Tucker, Christopher J. Quinkert, Pedro P. Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

47 to 53 percent of women over the age of 20 suffer from urinary incontinence, often caused by childbirth-related damage to the pelvic nerve. This uncertainty of when bladder voiding will occur causes social anxiety and can compromise quality of life. This study explores one method to restore the ability to sense the need to urinate and prevent unwanted voiding. We propose a device to measure pressure due to bladder content as the difference between pressure in the bladder and pressure in the abdominal cavity. Integrated circuits, biocompatible packaging, and wireless radiofrequency powering allow for a fully implantable device to ...


Development Of Micro-/Nano-Architectures For Intracellular Sensing Platform, Ryan M. Preston, Dae Seung Wie, Chi Hwan Lee Aug 2016

Development Of Micro-/Nano-Architectures For Intracellular Sensing Platform, Ryan M. Preston, Dae Seung Wie, Chi Hwan Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Currently available nanotechnologies are capable of creating various nanostructures in controlled dimensions such as particles (0D), wires (1D), membranes (2D), and cubes (3D) by exploiting “top-down” or “bottom-up” methods. However, there exist limitations to systematically construct hierarchical nanostructures with geometric complexities. This study is focused on developing a novel nanofabrication strategy that can rationally produce a set of hierarchical nanostructures configured with precisely engineered facets, tip shapes, and tectonic motifs. We aim to identify a collection of optimal materials, array layouts, basic components, and nanofabrication techniques for the production of hierarchical nanostructures by exploiting device-grade semiconducting silicon materials. To accomplish ...


Stimuli Responsive Fluidics Controls On A Paper-Based Bacterial Detection Platform, Siyu Zhao, Elizabeth Phillips, Jacqueline Linnes Aug 2016

Stimuli Responsive Fluidics Controls On A Paper-Based Bacterial Detection Platform, Siyu Zhao, Elizabeth Phillips, Jacqueline Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Infectious diseases are the leading causes of death around the world. Point-of-care devices using nucleic acid amplification are sensitive enough to diagnose these diseases, however, often require complex and time-intensive sample preparation steps that are not integrated with the detection process. A rapid, sensitive, and integrated sample-to-result diagnostic device will permit disease treatment planning at the point-of-care. Paper-based detection assays are a promising platform to integrate the sample preparation and detection, with minimal infrastructure, equipment, and user involvement. To integrate sample preparation with detection on paper-based assays, timing and delivery of sample fluid flow needs to be controlled. Here we ...


Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen Aug 2016

Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation ...


Pathway By Which Vagus Nerve Stimulation Of B Fibers Affects Heart Rate, Kelsey Wasilczuk, Matthew Ward, Pedro Irazoqui Aug 2016

Pathway By Which Vagus Nerve Stimulation Of B Fibers Affects Heart Rate, Kelsey Wasilczuk, Matthew Ward, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure (HF) affects over 5 million adults in the United States. Many HF patients have a high resting heart rate, which is correlated with a high mortality rate. In recent years, vagus nerve stimulation (VNS) has become an increasingly researched therapy to reduce the resting heart rate of HF patients. However, current dosage given during VNS is increased incrementally at the doctor’s office until side effects present themselves in a patient. In addition, the means by which the therapy works is not completely understood. To better understand the therapy’s mechanisms, the right cervical vagus nerve of several ...


An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics, Rui Shen, Jacqueline C. Linnes Aug 2015

An Investigation Of The Applicability Of Sugar And Wax Valves For Rapid Molecular Diagnostics, Rui Shen, Jacqueline C. Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Paper-based Loop-mediated Isothermal Amplification (LAMP) of nucleic acids is a low-cost molecular diagnostic method to detect biological pathogens and has been successfully combined with lateral flow devices. This invention is a low-cost visual detection technique of various disease. However, existing assays require multiple user-activated steps and are relatively complicated to use at the point of care due to steps like the heating process. This project aimed to investigate an ideal valve for integrating LAMP onto the lateral flow assay. An ideal valve needs to be able to stop the fluid flow for 20-60 minutes under 65 degree to complete the ...


Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System, Spencer Chiang, Yue Ren, Zheng Ouyang Aug 2015

Direct Analysis Of Pharmaceutical Drugs In Biofluids Using Miniature Mass Spectrometry System, Spencer Chiang, Yue Ren, Zheng Ouyang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Miniature mass spectrometry (MS) system is key for establishing MS as a point-of-care chemical and biological analysis within clinical settings. In order to provide point-of-care diagnostics, ionization methods for direct analysis of biofluids are required. We have previously introduced paper spray and developed the cartridges for direct MS ionization and sampling. Our goal of this research is to identify a viable way to improve the spray efficacy of paper spray for its coupling with miniature MS. As a result, paper capillary spray (PCS) was developed. PCS utilizes ET31 paper with a fused-silica capillary fixated to the tip. The design was ...


A Non-Invasive Method Of Measuring Respiration While Providing Wireless Power For Rodents With Implantable Devices, Jynx O. Boyne, Daniel J. Pederson, Zhi Wang, Pedro Irazoqui Dr. Aug 2015

A Non-Invasive Method Of Measuring Respiration While Providing Wireless Power For Rodents With Implantable Devices, Jynx O. Boyne, Daniel J. Pederson, Zhi Wang, Pedro Irazoqui Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Respiratory measurements can be used as diagnostic and research tools. Spirometry is the gold standard for gaining these measurements, but is difficult to use in rodents as it requires an invasive procedure. Total Body Plethysmograpy (TBP) is a non-invasive way to measure respiration rates that does not cause stress to the rodent. In this system, the subject is encased in a solid, constant volume chamber with measurements determining the subject’s respiration. When using TBP in medical or research settings, challenges occur in powering devices within the TBP chamber as wires and other recording equipment compromise the airtightness of the ...


Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation, Kelsey C. Bayer, Chris Quinkert, Pedro Irazoqui Aug 2015

Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation, Kelsey C. Bayer, Chris Quinkert, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Urinary incontinence (UI) is the involuntarily urination that usually effects older people or is the result of an injury. UI affects more than eleven million people and the cost of incontinence management in the United States in 2000 was $19.5 billion. Where conventional physical therapies have failed, pelvic nerve stimulation is a promising form of regulating the bladder long term. Piezoresistive pressure sensors consist of two variable resistance values and two known resistance values that are represented on a daughterboard. This unknown resistance represents the change in pressure. The filling and voiding of the bladder was characterized through acute ...


Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes Aug 2015

Quantification Of Analyte Concentration From A Paper-Based Lateral Flow Assay Device Using Reflective Sensors, Megan Z. Chiu, Jacqueline Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Paper-based point-of-care (POC) diagnostics is a growing field in global health due to the extreme portability, accuracy, affordability, and ease of use of these tests. Advancements in recent years have led to more accurate detection and improved functionality using multistep molecular diagnostics. Many such assays utilize lateral flow detection strips for visualization of diagnostic results by eye, which limits the results to qualitative Yes/No readouts. This project focused on combining recent developments in paper-based POC diagnostics to develop and optimize an in-house built quantitative paper-based diagnostic reader for lateral flow detection in low-resource settings. Initially different sensors, including photocell ...


An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui Aug 2015

An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Urinary Incontinence (UI) is a disease in which patients lose control of their bladder. It is particularly common in elderly women having a prevalence of as much as 30% to 50% [1]. Many of these patients are left without successful treatment. A recent study has shown a new option for treatment that consists of deep brain stimulation (DBS) at a site known as the periaqueductal gray (PAG) [2, 3]. To test the effectiveness of this treatment, chronic stimulation of the PAG should be used in animals to see if it can reliably prevent micturition in the long term. A device ...


Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs Aug 2015

Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz ...


Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui Aug 2014

Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Consistent powering is a limiting reagent for many medical implants and sensors. Powering in-vivo devices in animal studies requires either transcutaneous wiring (limiting mobility and increasing the chance of infection) or an implanted battery (limited lifetime and limits size of device). Wireless power transfer (WPT) would be able to overcome these challenges and permit the use of more advanced implantable devices in a research setting. Magnetic resonance coupling (MRC), an advanced form of inductive charging, allows good transfer efficiencies over significant air gaps, but works best a specific location and frequency, limiting mobility in animal studies. Using band-pass filter theory ...


Wirelessly Powered And Transmitting Current Sensing Device, Christopher Quinkert, Steven Lee, Pedro Irazoqui Aug 2014

Wirelessly Powered And Transmitting Current Sensing Device, Christopher Quinkert, Steven Lee, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

As the rate of incidence of diabetes increases in the modern world, more accurate and reliable methods of glucose detection must be developed for patients with diabetes. Currently, 25.8 million people have diabetes in the United States alone and account for $174 billion in healthcare costs annually [1]. Devices that can be used without the need for as much patient interaction, regular replacement, or great patient expenses would be a large step forward in the ability of doctors and patients to effectively manage diabetes. To measure glucose concentrations in vivo, a biosensor is used to transduce glucose to an ...