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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

City University of New York (CUNY)

2011

Proteomics

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Full-Text Articles in Biomedical Engineering and Bioengineering

Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc Jan 2011

Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc

Dissertations and Theses

"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells can be expanded in vitro for only limited passage numbers before they reach a senescent state. Previous studies have shown that long term culture of hMSCs results in the decrease in proliferation rates, changes in genomic expressions, increase in cell sizes, and other morphological changes. Currently the mechanisms of hMSC aging and biomarkers associated with it have not ...