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Biomedical Engineering and Bioengineering Commons

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City University of New York (CUNY)

2011

Charged Nanoparticles

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang Jan 2011

Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang

Dissertations and Theses

"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for the treatment of brain diseases. Recently therapeutic antibodies and a variety of drug-loaded nanoparticles (NPs) have been widely used to treat CNS disorders such as brain tumors, Alzheimer's disease and Parkinson's disease. To improve brain delivery efficacy of antibodies and NPs, it is necessary to quantify their transport parameters ...