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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

City University of New York (CUNY)

2011

Biomedics

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey Jan 2011

Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey

Dissertations and Theses

"Bone strength deteriorates with age; which increases the susceptibility to fracture. Current clinical techniques for the estimation of bone strength are largely Bone Mineral Density (BMD) based. However, toughness, which is the ability to resist crack growth, plays a critical role in bones‟ fracture resistance. Traditionally, toughness measurements involve large samples, obviating their use clinically. Recent data suggest that a reference point indentation approach provides a novel, localized measure of toughness from whole bones. In the current research, we evaluated the sensitivity of this method to discriminate small known differences in fracture toughness that exist between inbred mouse strains with ...