Biomedical Engineering and Bioengineering Commons^™

The Influence Of The Electrode Dimension On The Detection Sensitivity Of Electric Cell–Substrate Impedance Sensing (Ecis) And Its Mathematical Modeling, Xudong Zhang, William Wang, Anis Nurashikin Nordin, Fang Li, Sunghoon Jang, Ioana Voiculescu

Publications and Research

Detection sensitivity is a crucial criterion in the design and application of ECIS sensors. The influence of sensing electrode dimension on detection sensitivity is investigated in this paper. Eight types of ECIS sensors were fabricated, and their experimental results reveal that smaller-radius working electrodes generate more sensitive impedance shift to cell density change. Also, the smaller radius of working electrodes yield higher impedance values, which improves signal-to-noise ratio. In a range from 1.0 mm to 3.5 mm, the distance between the working and counter electrodes does not affect impedance measurements. However, the distance should be large enough to prevent the …