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Full-Text Articles in Biomedical Engineering and Bioengineering
Fluoride Treatment Increased Serum Igf-1, Bone Turnover, And Bone Mass, But Not Bone Strength, In Rabbits, C. Turner, L. Garetto, A. Dunipace, W. Zhang, M. Wilson, Marc Grynpas, Debbie Chachra, R. Mcclintock, M. Peacock, G. Stookey
Fluoride Treatment Increased Serum Igf-1, Bone Turnover, And Bone Mass, But Not Bone Strength, In Rabbits, C. Turner, L. Garetto, A. Dunipace, W. Zhang, M. Wilson, Marc Grynpas, Debbie Chachra, R. Mcclintock, M. Peacock, G. Stookey
Debbie Chachra
We hypothesized that fluoride partly acts by changing the levels of circulating calcium-regulating hormones and skeletal growth factors. The effects of oral fluoride on 24 female, Dutch-Belted, young adult rabbits were studied. The rabbits were divided into two study groups, one control and the other receiving about 16 mg fluoride/rabbit/day in their drinking water. After 6 months of fluoride dosing, all rabbits were euthanized and bone and blood samples were taken for analyses. Fluoride treatment increased serum and bone fluoride levels by over an order of magnitude (P < 0.001), but did not affect body weight or the following serum biochemical variables: urea, creatinine, phosphorus, total protein, albumin, bilirubin, SGOT, or total alkaline phosphatase. No skeletal fluorosis or osteomalacia was observed histologically, nor did fluoride affect serum PTH or Vitamin D metabolites (P > 0.4). BAP was increased 37% (P < 0.05) by fluoride; serum TRAP was increased 42% (P < 0.05); serum IGF-1 was increased 40% (P < 0.05). Fluoride increased the vertebral BV/TV by 35% (P …
Bone Quality In Animal Models Of Osteoporosis, Marc Grynpas, Debbie Chachra, Kathleen Lundon
Bone Quality In Animal Models Of Osteoporosis, Marc Grynpas, Debbie Chachra, Kathleen Lundon
Debbie Chachra
The use of animal models is a very powerful tool for the preclinical assessment of potential therapies for osteoporosis. However, the effective use of animal models has two prerequisites. The first is the use of appropriate techniques to assess the overall effects of therapy on bone. As spontaneous fractures do not occur in any species other than humans, the efficacy of a therapy cannot be assessed by its impact on fracture incidence. Instead, a suite of parameters (collectively referred to as ‘bone quality’), including bone architecture, mineralization and mechanical properties, is examined. While techniques such as histomorphometry and dual-energy x-ray …
Fluoride And Mineralized Tissues, Debbie Chachra, Anya Vieira, Marc Grynpas
Fluoride And Mineralized Tissues, Debbie Chachra, Anya Vieira, Marc Grynpas
Debbie Chachra
This review focuses on the interaction of fluoride with the material properties of bone and teeth, which is of clinical, scientific, and public health interest. These tissues are composed primarily of collagen (protein) and hydroxyapatite (mineral), and their mechanical function depends on the properties of the constituents, their proportions, the interface, and the three-dimensional structure. Changing any of these may have clinical consequences. Fluoride interacts with mineralized tissues in a number of ways. At low doses, the fluoride may be passively incorporated into the mineral, stabilizing it against dissolution; this is one of the mechanisms by which municipally fluoridated water …