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Biomedical Engineering and Bioengineering Commons

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Articles 1 - 7 of 7

Full-Text Articles in Biomedical Engineering and Bioengineering

Inhalable Nanocomposites And Anticancer Agents For Cancer Therapy, Nathanael A. Stocke Jan 2015

Inhalable Nanocomposites And Anticancer Agents For Cancer Therapy, Nathanael A. Stocke

Theses and Dissertations--Chemical and Materials Engineering

Cancer is designated as the leading cause of mortality worldwide and lung cancer is responsible for nearly 30% of all cancer related deaths. Over the last few decades mortality rates have only marginally increased and rates of recurrence remain high. These factors, among others, suggest the need for more innovative treatment modalities in lung cancer therapy. Targeted pulmonary delivery is well established for treating pulmonary diseases such as asthma and provides a promising platform for lung cancer therapy. Increasing local deposition of anticancer agents (ACAs) and reducing systemic exposure of these toxic moieties could lead to better therapeutic outcomes and ...


Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa Dec 2014

Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa

Electronic Thesis and Dissertation Repository

The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited ...


Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen Jan 2014

Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen

Electronic Thesis and Dissertation Repository

Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.

In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have ...


Polysaccharide-Based Nanocarriers For Improved Drug Delivery, Nan Zhang Aug 2013

Polysaccharide-Based Nanocarriers For Improved Drug Delivery, Nan Zhang

Dissertations - ALL

The field of drug delivery has provided a solution to the limited efficacy and high toxicity of many drugs. Nano-sized drug carriers are popular because their size allows for selective accumulation in the diseased area. Polysaccharides are non-toxic and biodegradable natural polymers that can serve as the basis for these nano-sized carriers. Polysialic acid (PSA) is such a polysaccharide with strong hydrophilicity that may reduce uptake by the reticuloendothelial system and prolong drug circulation. In this study, we developed PSA-based nanocarriers, specifically micelles and nanoparticles, for improved drug delivery with improved efficacy and minimized toxicity. PSA-based micelle systems were developed ...


High-Throughput Synthesis Of Carbohydrates And Functionalization Of Polyanhydride Nanoparticles, Brenda Rocio Carrillo-Conde, Rajarshi Roychoudhury, Ana Vianey Chavez-Santoscoy, Balaji Narasimhan, Nicola L.B. Pohl Jul 2012

High-Throughput Synthesis Of Carbohydrates And Functionalization Of Polyanhydride Nanoparticles, Brenda Rocio Carrillo-Conde, Rajarshi Roychoudhury, Ana Vianey Chavez-Santoscoy, Balaji Narasimhan, Nicola L.B. Pohl

Chemical and Biological Engineering Publications

Transdisciplinary approaches involving areas such as material design, nanotechnology, chemistry, and immunology have to be utilized to rationally design efficacious vaccines carriers. Nanoparticle-based platforms can prolong the persistence of vaccine antigens, which could improve vaccine immunogenicity 1. Several biodegradable polymers have been studied as vaccine delivery vehicles 1; in particular, polyanhydride particles have demonstrated the ability to provide sustained release of stable protein antigens and to activate antigen presenting cells and modulate immune responses 2-12. The molecular design of these vaccine carriers needs to integrate the rational selection of polymer properties as well as the incorporation of appropriate targeting agents ...


Mannose-Functionalized "Pathogen-Like" Polyanhydride Nanoparticles Target C-Type Lectin Receptors On Dendritic Cells, Brenda Rocio Carrillo-Conde, Eun-Ho Song, Ana Vianey Chavez-Santoscoy, Yashdeep Phanse, Amanda Ellen Ramer-Tait, Nicola L.B. Pohl, Michael J. Wannemuehler, Bryan H. Bellaire, Balaji Narasimhan Jan 2011

Mannose-Functionalized "Pathogen-Like" Polyanhydride Nanoparticles Target C-Type Lectin Receptors On Dendritic Cells, Brenda Rocio Carrillo-Conde, Eun-Ho Song, Ana Vianey Chavez-Santoscoy, Yashdeep Phanse, Amanda Ellen Ramer-Tait, Nicola L.B. Pohl, Michael J. Wannemuehler, Bryan H. Bellaire, Balaji Narasimhan

Chemical and Biological Engineering Publications

Targeting pathogen recognition receptors on dendritic cells (DCs) offers the advantage of triggering specific signaling pathways to induce a tailored and robust immune response. In this work, we describe a novel approach to targeted antigen delivery by decorating the surface of polyanhydride nanoparticles with specific carbohydrates to provide "pathogen-like" properties that ensure nanoparticles engage C-type lectin receptors on DCs. The surface of polyanhydride nanoparticles was functionalized by covalent linkage of dimannose and lactose residues using an amine-carboxylic acid coupling reaction. Coculture of functionalized nanoparticles with bone marrow-derived DCs significantly increased cell surface expression of MHC II, the T cell costimulatory ...


Functionalized Nanoparticles For Biological Imaging And Detection Applications, Bing C Mei Feb 2009

Functionalized Nanoparticles For Biological Imaging And Detection Applications, Bing C Mei

Doctoral Dissertations 1896 - February 2014

Semiconductor quantum dots (QDs) and gold nanoparticles (AuNPs) have gained tremendous attention in the last decade as a result of their size-dependent spectroscopic properties. These nanoparticles have been a subject of intense study to bridge the gap between macroscopic and atomic behavior, as well as to generate new materials for novel applications in therapeutics, biological sensing, light emitting devices, microelectronics, lasers, and solar cells. One of the most promising areas for the use of these nanoparticles is in biotechnology, where their size-dependent optical properties are harnessed for imaging and sensing applications. However, these nanoparticles, as synthesized, are often not stable ...