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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics

MRNA

2011

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Full-Text Articles in Biomedical Engineering and Bioengineering

Dna− Gold Nanoparticle Reversible Networks Grown On Cell Surface Marker Sites: Application In Diagnostics, Kyuwan Lee Feb 2011

Dna− Gold Nanoparticle Reversible Networks Grown On Cell Surface Marker Sites: Application In Diagnostics, Kyuwan Lee

Kyuwan Lee

Effective identification of breast cancer stem cells (CSC) benefits from a multiplexed approach to detect cell surface markers that can distinguish this subpopulation, which can invade and proliferate at sites of metastasis. We present a new approach for dual-mode sensing based on targeting using pointer and signal enhancement using enhancer particle networks for detection by surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS). We demonstrate our concept to detect cell surface markers, CD44 and CD24, in three breast cancer cell lines to identify a CD44+/CD24− subpopulation of CSCs. The designed network structure can be well-controlled and has improved ...