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Biomedical Engineering and Bioengineering Commons

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Physical Sciences and Mathematics

Theses and Dissertations

Oxidative Stress

2012

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Optical Cryoimaging Of Celular Redox In Kidneys From Diabetic Mice, Sepideh Maleki Aug 2012

Optical Cryoimaging Of Celular Redox In Kidneys From Diabetic Mice, Sepideh Maleki

Theses and Dissertations

Diabetic Nephropathy (DN) is the major single cause of end stage renal diseases (ESRD) in the United States. Diabetes is the third leading fatal disorder after cancer and heart disease. It is affecting 8.3% of the residents of the United States, with a total healthcare cost of $174 billion/yr by 2010.

There currently exists a need for a sensitive and specific diagnosis for temporal detection of oxidative stress (OS) in cellular metabolic levels, which plays an early role in the development of DN. The objective of this research is to use a fluorescence optical imaging technique in order ...