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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr Dec 2011

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr

Publicly Accessible Penn Dissertations

Diffuse Optical Tomography and Spectroscopy permit measurement of important physiological parameters non-invasively through ~10 cm of tissue. I have applied these techniques in measurements of human breast and breast cancer. My thesis integrates three loosely connected themes in this context: multi-modal breast cancer imaging, automated data analysis of breast cancer images, and microvascular hemodynamics of breast under compression. As per the first theme, I describe construction, testing, and the initial clinical usage of two generations of imaging systems for simultaneous diffuse optical and magnetic resonance imaging. The second project develops a statistical analysis of optical breast data from many spatial ...


Cerebral Hemodynamics In High-Risk Neonates Probed By Diffuse Optical Spectroscopies, Erin M. Buckley Aug 2011

Cerebral Hemodynamics In High-Risk Neonates Probed By Diffuse Optical Spectroscopies, Erin M. Buckley

Publicly Accessible Penn Dissertations

Advances in medical and surgical care of the critically ill neonates have decreased
mortality, yet a significant number of these neonates suffer from neurodevelopmental
delays and failure in school. Thus, clinicians are now focusing on prevention of
neurologic injury and improvement of neurocognitive outcome in these high-risk infants. Assessment of cerebral oxygenation, cerebral blood volume, and the regulation of cerebral blood flow (CBF) during the neonatal period is vital for evaluating brain health. Traditional CBF imaging methods fail, however, for both ethical and logistical reasons. In this dissertation, I demonstrate the use of non-invasive optical modalities, i.e., diffuse optical ...


Statistical Medial Model Dor Cardiac Segmentation And Morphometry, Hui Sun May 2010

Statistical Medial Model Dor Cardiac Segmentation And Morphometry, Hui Sun

Publicly Accessible Penn Dissertations

In biomedical image analysis, shape information can be utilized for many purposes. For example, irregular shape features can help identify diseases; shape features can help match different instances of anatomical structures for statistical comparison; and prior knowledge of the mean and possible variation of an anatomical structure's shape can help segment a new example of this structure in noisy, low-contrast images. A good shape representation helps to improve the performance of the above techniques. The overall goal of the proposed research is to develop and evaluate methods for representing shapes of anatomical structures. The medial model is a shape ...


Mechanical And Chemical Effects In Adhesion Of Thin Shell Structures With Applications In Wafer Bonding And Adhesion Of Living Cells, Richard M. Springman Aug 2009

Mechanical And Chemical Effects In Adhesion Of Thin Shell Structures With Applications In Wafer Bonding And Adhesion Of Living Cells, Richard M. Springman

Publicly Accessible Penn Dissertations

A theoretical model is analyzed to investigate the adhesion of thin shell structures to both rigid and deformable substrates under a variety of surface conditions. The thermodynamic forces driving the adhesive process are determined from an interfacial free energy, which is described within a classical thermodynamics framework. Deformations of the thin, elastic shells are studied using a geometrically nonlinear shell theory. Finite-range adhesive tractions, chemical segregation, substrate compliance, and substrate topography all are considered over a wide range of geometric and material parameters. Equilibrium adhesion states are characterized by a shell flatness parameter, the contact radius, and the adhesive and ...