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Full-Text Articles in Biomedical Engineering and Bioengineering

Foodlocker: An Online Marketplace For Automated Meals, Josiah Buxton Jan 2019

Foodlocker: An Online Marketplace For Automated Meals, Josiah Buxton

Computer Science Graduate Theses & Dissertations

Food waste is a major problem for the human race, particularly in "rich" industrial countries.

We propose a creative, partial solution to this problem through the development of an online marketplace for left-over food and a physical infrastructure to secure the food throughout each transaction.

The software platform will consist of three separate portions: a mobile food consumer application, a mobile food provider application, and a web food provider application. Restaurants and other licensed food distributors can utilize the food provider applications to broadcast available left-over meals, which can be purchased at a discounted price. The hardware infrastructure will be ...


Nanoscale Stiffness Cues Influence Valvular Interstitial Cell Activation To Myofibroblasts, Michaela Wenning Jan 2019

Nanoscale Stiffness Cues Influence Valvular Interstitial Cell Activation To Myofibroblasts, Michaela Wenning

Undergraduate Honors Theses

Surgery is currently the primary treatment option for aortic valve stenosis (AVS) patients, many of whom are ineligible for surgery and are left untreated. AVS is progression is known to differ between males and females, and an understanding of sex-specific mechanisms of disease progression is imperative in developing accurate treatment options for men and women. The development of a nonsurgical therapy for AVS patients requires a deeper understanding of the molecular and cellular mechanisms of AVS progression. Currently, the role of calcium phosphate nanoparticles detected in the aortic valve during early stages of AVS in influencing disease progression and valvular ...


Development And Characterization Of Improved Red Fluorescent Protein Variants, Premashis Manna Jan 2018

Development And Characterization Of Improved Red Fluorescent Protein Variants, Premashis Manna

Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)

Aequorea victoria-based green fluorescent proteins and their blue, cyan and red counterparts offer unprecedented advantage as biological markers owing to their genetic encodability and straightforward expression in different organisms. Fluorescent proteins are characterized with complex photo-kinetics due to the presence of light-induced non-fluorescent or dark states which are responsible for their fluorescence intermittency or 'blinking'. We developed time- and frequency-domain techniques for probing the kinetics involving dark state conversion (DSC) and ground state recovery (GSR) in red fluorescent proteins (RFPs). Ensemble-level DSC and GSR kinetics in FPs were presented in the context of their single molecule fluorescence behaviors. Although ...


Application Of Advances In Synthetic Biology To Modular Megasynthase Design And Scalable Combinatorial Biosynthesis, William Clifford Grau Jan 2018

Application Of Advances In Synthetic Biology To Modular Megasynthase Design And Scalable Combinatorial Biosynthesis, William Clifford Grau

Chemistry & Biochemistry Graduate Theses & Dissertations (1986-2018)

The diversity in structure and biological activity of natural products has long captured the imagination of chemists and molecular biologists alike. Natural products are synthesized by elaborate secondary metabolic pathways or enzymes. For example, modular megasynthases such as Type I Polyketide Synthases (PKSs), Non-ribosomal Peptide Synthetases (NRPSs), and PKS-NRPS hybrids, produce an array of quintessential natural products. The apparent modularity, defined architecture, and predictable chemistry of modular megasynthases make them especially attractive for combinatorial biosynthesis, which has long been a focus of biotechnology. Combinatorial biosynthetic libraries are of particular interest due to the high value of many natural products and ...


Modeling Alveolar Epithelial Cell Behavior In Spatially Designed Hydrogel Microenvironments, Katherine Jean Reeder Lewis Jan 2016

Modeling Alveolar Epithelial Cell Behavior In Spatially Designed Hydrogel Microenvironments, Katherine Jean Reeder Lewis

Chemical & Biological Engineering Graduate Theses & Dissertations

The alveolar epithelium consists of two cell phenotypes, elongated alveolar type I cells (AT1) and rounded alveolar type II cells (ATII), and exists in a complex three-dimensional environment as a polarized cell layer attached to a thin basement membrane and enclosing a roughly spherical lumen. Closely surrounding the alveolar cysts are capillary endothelial cells as well as interstitial pulmonary fibroblasts. Many factors are thought to influence alveolar epithelial cell differentiation during lung development and wound repair, including physical and biochemical signals from the extracellular matrix (ECM), and paracrine signals from the surrounding mesenchyme. In particular, disrupted signaling between the alveolar ...


Process Extension From Embryonic Stem Cell-Derived Motor Neurons Through Synthetic Extracellular Matrix Mimics, Daniel Devaud Mckinnon Jan 2014

Process Extension From Embryonic Stem Cell-Derived Motor Neurons Through Synthetic Extracellular Matrix Mimics, Daniel Devaud Mckinnon

Chemical & Biological Engineering Graduate Theses & Dissertations

This thesis focuses on studying the extension of motor axons through synthetic poly(ethylene glycol) PEG hydrogels that have been modified with biochemical functionalities to render them more biologically relevant. Specifically, the research strategy is to encapsulate embryonic stem cell-derived motor neurons (ESMNs) in synthetic PEG hydrogels crosslinked through three different chemistries providing three mechanisms for dynamically tuning material properties. First, a covalently crosslinked, enzymatically degradable hydrogel is developed and exploited to study the biophysical dynamics of axon extension and matrix remodeling. It is demonstrated that dispersed motor neurons require a battery of adhesive peptides and growth factors to maintain ...


Fundamental Characterization Of Photodegradable Hydrogels: Spatiotemporal Control Of The Cellular Microenvironment, Mark William Tibbitt Jan 2012

Fundamental Characterization Of Photodegradable Hydrogels: Spatiotemporal Control Of The Cellular Microenvironment, Mark William Tibbitt

Chemical & Biological Engineering Graduate Theses & Dissertations

Synthetic hydrogels are an attractive class of materials for the design of well-defined cell culture platforms to better understand how cells receive and integrate signals present in the extracellular environment. Within this class, responsive hydrogels have emerged to investigate questions as to how cells sense and respond to dynamic changes in the mechanical and biochemical nature of the cell niche. To complement this growing body of research, this thesis aimed to develop photoresponsive, synthetic hydrogels that enable experimenters to explore how spatiotemporally varying cues from the extracellular matric influence biological function in real time. Specifically, cytocompatible, chain and step polymerized ...


Analysis And Simulation Of Partial Differential Equations In Mathematical Biology: Applications To Bacterial Biofilms And Fisher's Equation, Jason Frank Hammond Jan 2012

Analysis And Simulation Of Partial Differential Equations In Mathematical Biology: Applications To Bacterial Biofilms And Fisher's Equation, Jason Frank Hammond

Applied Mathematics Graduate Theses & Dissertations

In this dissertation, we investigate two important problems in mathematical biology that are best modeled using partial differential equations. We first consider the question of how surface-adherent bacterial biofilm communities respond in flowing systems, simulating the interaction and separation process using the immersed boundary method. We use the incompressible viscous Navier-Stokes (N-S) equations to describe the motion of the flowing fluid. In these simulations we can assign different density and viscosity values to the biofilm than that of the surrounding fluid. The simulation also includes breakable springs connecting the particles in the biofilm. This allows the inclusion of erosion and ...