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Hepcidin Plays A Key Role In 6-Ohda Induced Iron Overload And Apoptotic Cell Death In A Cell Culture Model Of Parkinson’S Disease, Qi Xu, Anumantha G. Kanthasamy, Huajun Jin, Manju B. Reddy May 2016

Hepcidin Plays A Key Role In 6-Ohda Induced Iron Overload And Apoptotic Cell Death In A Cell Culture Model Of Parkinson’S Disease, Qi Xu, Anumantha G. Kanthasamy, Huajun Jin, Manju B. Reddy

Food Science and Human Nutrition Publications

Background. Elevated brain iron levels have been implicated in the pathogenesis of Parkinson’s disease (PD). However, the precise mechanism underlying abnormal iron accumulation in PD is not clear. Hepcidin, a hormone primarily produced by hepatocytes, acts as a key regulator in both systemic and cellular iron homeostasis. Objective. We investigated the role of hepcidin in 6-hydroxydopamine (6-OHDA) induced apoptosis in a cell culture model of PD. Methods. We downregulated hepcidin using siRNA interference in N27 dopaminergic neuronal cells and made a comparison with control siRNA transfected cells to investigate the role of hepcidin in 6-OHDA induced neurodegeneration. Results. Hepcidin ...