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Biomedical Engineering and Bioengineering Commons

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Molecular, Cellular, and Tissue Engineering

Biomedical Engineering Undergraduate Honors Theses

2018

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Full-Text Articles in Biomedical Engineering and Bioengineering

Effects Of Gsk101 Exposure On Astrocyte Mechanical Properties, Collagen Production, And Viability, Ethan Echols May 2018

Effects Of Gsk101 Exposure On Astrocyte Mechanical Properties, Collagen Production, And Viability, Ethan Echols

Biomedical Engineering Undergraduate Honors Theses

Transient receptor potential vanilloid 4 (TRPV4) is a cation channel protein which is thought to facilitate extracellular matrix (ECM) modification and glial scar formation following traumatic brain injury (TBI). Activation of TRPV4 has been shown to correlate with an increase in intracellular Ca2+ concentration. TRPV4 is subject to both chemical and mechanical activation. This study involved chemical activation of TRPV4 in cultured mouse astrocytes using GSK101, the primary agonist of TRPV4, and subsequent evaluation of mechanical and chemical changes to the ECM. Prior to GSK101 exposure, the cells were seeded into Matrigel Matrix, a gelatinous protein mixture intended to ...


Quantification Of Tumor-Associated Macrophages Following Immunomodulation Therapy In A Murine Allograft Model Of Colorectal Carcinoma, Caroline Spainhour May 2018

Quantification Of Tumor-Associated Macrophages Following Immunomodulation Therapy In A Murine Allograft Model Of Colorectal Carcinoma, Caroline Spainhour

Biomedical Engineering Undergraduate Honors Theses

Colorectal Carcinoma (CRC) is one of the deadliest cancers in the world, with 150,000 new cases annually in the United States. Traditional treatments include chemotherapy and invasive surgery; however, research has shown that only 25% of patients that undergo traditional treatment have a positive result. Immunotherapy is an emerging form of cancer treatment that utilizes the patients’immune system to fight cancer cells by targeting inflammation, which plays a large role in the proliferation and metastasis of cancer cells.

Tumor-associated macrophages (TAMs) are immune cells that affect the inflammatory microenvironment of tumors. TAMs are M1 in the early stages ...