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Full-Text Articles in Biomedical Engineering and Bioengineering

The Design, Fabrication, And Characterization Of Nanoparticle-Protein Interactions For Theranostic Applications, Wai Hei Tse Aug 2017

The Design, Fabrication, And Characterization Of Nanoparticle-Protein Interactions For Theranostic Applications, Wai Hei Tse

Electronic Thesis and Dissertation Repository

Theranostics, a combination of therapeutics and diagnostics, spans a spectrum of research areas to provide new opportunities in developing new healthcare technologies and medicine at affordable prices. Through employing a personalized medicine approach, biotechnology can be tailored to the needs of an individual. Applications of theranostics include drug delivery carriers capable of sustained drug release and targeted delivery, biosensors with high sensitivity and selectivity, and diagnostic relevant entities that can be incorporated into the former technologies. Nanotechnology provides a suitable foundation for theranostics to build upon due to material-based properties; magnetism, biocompatibility, and quantum effects to name a few. Purpose ...


Mri-Based Attenuation Correction In Emission Computed Tomography, Harry R. Marshall May 2012

Mri-Based Attenuation Correction In Emission Computed Tomography, Harry R. Marshall

Electronic Thesis and Dissertation Repository

The hybridization of magnetic resonance imaging (MRI) with positron emission tomography (PET) or single photon emission computed tomography (SPECT) enables the collection of an assortment of biological data in spatial and temporal register. However, both PET and SPECT are subject to photon attenuation, a process that degrades image quality and precludes quantification. To correct for the effects of attenuation, the spatial distribution of linear attenuation coefficients (μ-coefficients) within and about the patient must be available. Unfortunately, extracting μ-coefficients from MRI is non-trivial. In this thesis, I explore the problem of MRI-based attenuation correction (AC) in emission tomography.

In particular, I ...


Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman Jun 2011

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Robarts Imaging Publications

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate ...


Modeling Lung Tissue Motions And Deformations: Applications In Tumor Ablative Procedures, Ali Sadeghi Naini May 2011

Modeling Lung Tissue Motions And Deformations: Applications In Tumor Ablative Procedures, Ali Sadeghi Naini

Electronic Thesis and Dissertation Repository

Various types of motion and deformation that the lung undergoes during minimally invasive tumor ablative procedures have been investigated and modeled in this dissertation. The lung frequently undergoes continuous large respiratory deformation, which can greatly affect the pre-planned outcome of the operation, hence deformation compensation becomes necessary. The first type of major deformation involved in a target lung throughout a tumor ablative procedure is the one encountered in procedures where the lung is totally deflated before starting the operation. A consequence of this deflation is that pre-operative images (acquired while the lung was partially inflated) become inaccurate for targeting the ...