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Full-Text Articles in Biomedical Engineering and Bioengineering

Collagen Organization Deposited By Fibroblasts Encapsulated In Ph Responsive Methacrylated Alginate Hydrogels, Anuraag Boddupalli, Kaitlin M. Bratlie Jan 2018

Collagen Organization Deposited By Fibroblasts Encapsulated In Ph Responsive Methacrylated Alginate Hydrogels, Anuraag Boddupalli, Kaitlin M. Bratlie

Materials Science and Engineering Publications

The pH of dermal wounds shifts from neutral during the inflammatory phase to slightly basic in the tissue remodeling phase. Stage specific wound treatment can be developed using environmentally responsive alginate hydrogels. The chemistry of these networks dictates swelling behavior. Here, we fabricated alginate hydrogels using chain growth, step growth, and combined mixed mode gelation methods to crosslink methacrylated alginate (ALGMA) and gain control over swelling responses. Methacrylation of the alginate network was confirmed through NMR spectroscopy. Strontium cations were introduced to fabricate stiffer, dually crosslinked hydrogels. Dual crosslinking significantly decreased the swelling response over the pH range of 3 ...


Bioactive Poly(Beta-Amino Ester) Biomaterials For Treatment Of Infection And Oxidative Stress, Andrew L. Lakes Jan 2016

Bioactive Poly(Beta-Amino Ester) Biomaterials For Treatment Of Infection And Oxidative Stress, Andrew L. Lakes

Theses and Dissertations--Chemical and Materials Engineering

Polymers have deep roots as drug delivery tools, and are widely used in clinical to private settings. Currently, however, numerous traditional therapies exist which may be improved through use of polymeric biomaterials. Through our work with infectious and oxidative stress disease prevention and treatment, we aimed to develop application driven, enhanced therapies utilizing new classes of polymers synthesized in-house. Applying biodegradable poly(β-amino ester) (PBAE) polymers, covalent-addition of bioactive substrates to these PBAEs avoided certain pitfalls of free-loaded and non-degradable drug delivery systems. Further, through variation of polymer ingredients and conditions, we were able to tune degradation rates, release profiles ...


Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu Aug 2014

Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Due to the high prevalence of arthritis and cartilage-related injuries, tissue engineers are studying ways to grow cartilage tissue replacements. Resilin, an elastomeric protein found in insect cuticles, is known for its extraordinary resilience and elasticity. In previous studies, recombinant resilin-based hydrogels, or cross-linked protein networks, exhibited potential for use in cartilage tissue scaffolds. Our lab successfully developed resilin-based proteins with a sequence based on the mosquito gene and showed that resilin-based hydrogels possess mechanical properties of the same order of magnitude as native articular cartilage. In addition, these mechanical properties can be controlled by changing the protein concentration. To ...


Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu Oct 2013

Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive ...


Integrin Binding Peptide-Functionalized Poly(Ethylene Glycol) Hydrogels For Understanding The Role Of Matricellular Effects On Vic Phenotype And Tissue Deposition, Sarah Trexler Gould Jan 2013

Integrin Binding Peptide-Functionalized Poly(Ethylene Glycol) Hydrogels For Understanding The Role Of Matricellular Effects On Vic Phenotype And Tissue Deposition, Sarah Trexler Gould

Chemical & Biological Engineering Graduate Theses & Dissertations

Aortic valve stenosis (AS) results in almost 100,000 valve replacement surgeries per year in the United States. These replacements are generally made of synthetic materials that require anticoagulants or decellularized allo/xenografts that tend to quickly calcify in younger patients. Valve replacements containing cells able to grow and repair damaged valve tissue could positively impact patient morbidity. However, matricellular cues associated with healthy tissue deposition by the resident aortic valvular interstitial cells (VICs) are still not well understood. This thesis aims to study the effects and underlying mechanisms of matrix elasticity and biochemical cues (e.g., bound integrins or ...