Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
Microfluidic Devices For Terahertz Spectroscopy Of Biomolecules, P. A. George, W. Hui, F. Rana, Benjamin G. Hawkins, A. E. Smith, B. J. Kirby
Microfluidic Devices For Terahertz Spectroscopy Of Biomolecules, P. A. George, W. Hui, F. Rana, Benjamin G. Hawkins, A. E. Smith, B. J. Kirby
Benjamin G. Hawkins
We demonstrate microfluidic devices for terahertz spectroscopy of biomolecules in aqueous solutions. The devices are fabricated out of a plastic material that is both mechanically rigid and optically transparent with near-zero dispersion in the terahertz frequency range. Using a low-power terahertz time-domain spectrometer, we experimentally measure the absorption spectra of the vibrational modes of bovine serum albumin from 0.5–2.5 THz and find good agreement with previously reported data obtained using large-volume solutions and a high-power free-electron laser. Our results demonstrate the feasibility of performing high sensitivity terahertz spectroscopy of biomolecules in aqueous solutions with detectable molecular quantities as small as …
Microfluidic Devices For Terahertz Spectroscopy Of Biomolecules, P. A. George, W. Hui, F. Rana, Benjamin G. Hawkins, A. E. Smith, B. J. Kirby
Microfluidic Devices For Terahertz Spectroscopy Of Biomolecules, P. A. George, W. Hui, F. Rana, Benjamin G. Hawkins, A. E. Smith, B. J. Kirby
Faculty Publications
We demonstrate microfluidic devices for terahertz spectroscopy of biomolecules in aqueous solutions. The devices are fabricated out of a plastic material that is both mechanically rigid and optically transparent with near-zero dispersion in the terahertz frequency range. Using a low-power terahertz time-domain spectrometer, we experimentally measure the absorption spectra of the vibrational modes of bovine serum albumin from 0.5–2.5 THz and find good agreement with previously reported data obtained using large-volume solutions and a high-power free-electron laser. Our results demonstrate the feasibility of performing high sensitivity terahertz spectroscopy of biomolecules in aqueous solutions with detectable molecular quantities as small as …