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Full-Text Articles in Engineering
Changes In Pulmonary Arterial Wall Mechanical Properties And Lumenal Architecture With Induced Vascular Remodeling, Robert C. Molthen, Amy Heinrich, Steven Thomas Haworth, Christopher A. Dawson
Changes In Pulmonary Arterial Wall Mechanical Properties And Lumenal Architecture With Induced Vascular Remodeling, Robert C. Molthen, Amy Heinrich, Steven Thomas Haworth, Christopher A. Dawson
Biomedical Engineering Faculty Research and Publications
To explore and quantify pulmonary arterial remodeling we used various methods including micro-CT, high-resolution 3-dimensional x-ray imaging, to examine the structure and function of intact pulmonary vessels in isolated rat lungs. The rat is commonly used as an animal model for studies of pulmonary hypertension (PH) and the accompanying vascular remodeling, where vascular remodeling has been defined primarily by changes in the vessel wall composition in response to hypertension inducing stimuli such as chronic hypoxic exposure (CHE) or monocrotaline (MCT) injection. Little information has been provided as to how such changes affect the vessel wall mechanical properties or the lumenal …
Quantification Of Pulmonary Arterial Wall Distensibility Using Parameters Extracted From Volumetric Micro-Ct Images, Roger H. Johnson, Kelly Lynn Karau, Robert C. Molthen, Christopher A. Dawson
Quantification Of Pulmonary Arterial Wall Distensibility Using Parameters Extracted From Volumetric Micro-Ct Images, Roger H. Johnson, Kelly Lynn Karau, Robert C. Molthen, Christopher A. Dawson
Biomedical Engineering Faculty Research and Publications
Stiffening, or loss of distensibility, of arterial vessel walls is among the manifestations of a number of vascular diseases including pulmonary arterial hypertension. We are attempting to quantify the mechanical properties of vessel walls of the pulmonary arterial tree using parameters derived from high-resolution volumetric x-ray CT images of rat lungs. The pulmonary arterial trees of the excised lungs are filled with a contrast agent. The lungs are imaged with arterial pressures spanning the physiological range. Vessel segment diameters are measured from the inlet to the periphery, and distensibilities calculated from diameters as a function of pressure. The method shows …