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Engineering Bioerodible Polymers With Tailored Micro/Nanostructure For Vaccine Delivery , Matthew J. Kipper
Retrospective Theses and Dissertations
This work describes the investigation of bioerodible polyanhydrides as controlled drug delivery vehicles. The polymers studied are based on the 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic acid (SA) monomers. These two materials erode at vastly different rates and can be combined in random copolymers or blends to achieve tailored erosion kinetics. The hydrophobic nature of these materials offers the potential to stabilize proteins, and their mutual incompatibility and semicrystallinity provide an interesting phase behavior, which can be exploited to aid in tailoring the release kinetics. Theoretical and experimental description of the microstructure of polyanhydride copolymers reveals the details of ...