Engineering Commons^™

Quantitative Metrics For Mutation Testing, Amani M. Ayad

Dissertations

Program mutation is the process of generating versions of a base program by applying elementary syntactic modifications; this technique has been used in program testing in a variety of applications, most notably to assess the quality of a test data set. A good test set will discover the difference between the original program and mutant except if the mutant is semantically equivalent to the original program, despite being syntactically distinct.

Equivalent mutants are a major nuisance in the practice of mutation testing, because they introduce a significant amount of bias and uncertainty in the analysis of test results; indeed, mutants …

Customized Boron And Magnesium-Based Reactive Materials Prepared By High Energy Mechanical Milling, Xinhang Liu

Dissertations

New reactive materials need to be developed having biocidal combustion products. When ignited, such material can add chemical biocidal effects to the common effects of high temperature and pressure. Biocidal combustion products are capable of deactivating harmful spores or bacteria, which can be released by targets containing biological weapons of mass destruction. Research showed that halogens, especially iodine, are effective as biocidal components of reactive material formulations. Recently, magnesium combustion product MgO is also found to have a biocidal effect. Thus, advanced formulations containing both magnesium and iodine are of interest; such formulations are prepared and investigated here.

Reactive materials …

Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng

Dissertations

Efficient clearance of interstitial waste metabolites is essential for normal brain homeostasis. Such effective clearance is hampered by the lack of a lymphatic system in the brain, and the cerebrospinal fluid (CSF) is unable to clear large size waste metabolites in the brain. Here, a novel idea that brain arterial endothelium and smooth muscle cells reactivity regulates the clearance of these water-insoluble large size waste metabolites through the perivascular dynamic exchange, and that low dose ethanol promotes this perivascular clearance is proposed.

In Aim 1, the biodistribution of a large size waste metabolite (Amyloid-β protein mimic) in rat perivascular space …

Bio-Inspired Learning And Hardware Acceleration With Emerging Memories, Shruti R. Kulkarni

Dissertations

Machine Learning has permeated many aspects of engineering, ranging from the Internet of Things (IoT) applications to big data analytics. While computing resources available to implement these algorithms have become more powerful, both in terms of the complexity of problems that can be solved and the overall computing speed, the huge energy costs involved remains a significant challenge. The human brain, which has evolved over millions of years, is widely accepted as the most efficient control and cognitive processing platform. Neuro-biological studies have established that information processing in the human brain relies on impulse like signals emitted by neurons called …

Cerebro-Vascular Disruption Mediated Initiation And Propagation Of Traumatic Brain Injury In A Fluid Percussion Injury Model, Xiaotang Ma

Dissertations

Traumatic brain injury (TBI) is a major health problem for over 3.17 million people in the US. There is no FDA-approved drug for the treatment because the injury mechanisms have not been clearly identified. The knowledge gap is addressed here by the lateral fluid percussion injury (FPI) rat model, through the understanding of layer-structured mechanisms from physical vascular rupture to acute necrosis, as well as biochemical changes in perivascular space as secondary events.

Firstly, the cerebrovascular hemorrhage and related infarct volume are investigated as the primary events in moderate FPI, which is found to be increased with injury severity in …

Micro Pipes – A Portable Integrated Platform For Electrochemical Sensing Using Essence Architecture, Hansin Kim

Theses

The field of microfluidics and lab-on-chip (LOC) technology has the potential to have a truly transformative effect in biological engineering. This includes areas such as single-cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Yet despite being the subject of intense research over the past two decades, LOC devices have not been widely adopted. It is increasingly evident that there is a need for an effective and adaptable integration strategy to realize the potential of this technology.

Presented in this thesis is a design for a chip-to-world interface that aims to improve integration while maintaining cost-efficiency and ease of fabrication. …

Study And Modelling Of Lithium Ion Cell With Accurate Soc Measurement Algorithm Using Kalman Filter For Electric Vehicles, Kasthuriramanan Mahendravadi Sivaguru

Theses

Lithium Ion cells are preferred over lead acid cells for electric vehicles due to their energy density, higher discharge current and size. The cost of lithium ion cells is scaling down compared to ten years earlier, but as their performance characteristics increase, the need for safety and accurate modelling also increases.

The absence of a generic cell model is associated to the different makes of cells and different chemistries of Lithium ion cells behave differently under the testing conditions required for every unique application. The focus of this thesis will be on how to provide intelligence to the battery management …

Impact Of Stirrer Speed And Media Type-Loading On The Breakage Kinetics During Wet Stirred Media Milling Of Griseofulvin, Nathaniel Parker

Theses

The aim of this study is to investigate the impact of stirrer speed (2000-4000 rpm) and bead loading (~20-60%) on the breakage kinetics-energy consumption during milling of griseofulvin, a poorly soluble drug, and compare the performance of crosslinked polystyrene (CPS) beads with that of yttrium-stabilized zirconia (YSZ) beads. Laser diffraction, SEM, viscometry, and XRPD were used for characterization. A microhydrodynamic model was used to interpret the breakage kinetics. An increase in stirrer speed led to faster breakage due to more frequent and forceful CPS bead-bead collisions. Despite causing slight decrease in maximum contact pressure, an increase in CPS bead loading …

Effect Of 3d Printed Tablet Shape On Drug Release Profile, Christina Gedeon

Theses

There is a growing interest in utilizing additive manufacturing (AM) as a manufacturing tool to develop oral tablets for personalized medicine. This ultimate goal in mind, this study explores the feasibility of extrusion-based fused deposition modeling (FDM) to 3D print oral tablets with tunable design to control drug release profile. Tablets are printed using poly(vinyl alcohol) (PVA) loaded with model drugs: acetaminophen and caffeine. Hot melt extrusion (HME) is used to fabricate PVA filaments loaded with acetaminophen and caffeine. These filaments are used to fabricate a range of tablets with varying designs to prepare immediate and delayed release tablets. Thermal …

Lithium As A Possible Therapeutic Drug In Posttraumatic Brain Injury, Tulika Das

Theses

Lithium, a popular drug for treating mental health disorder has shown promising effect in recent research on traumatic brain injury (TBI). The mechanism of lithium for treating bipolar mood disorder is still not properly understood, but recent studies showed that lithium is neuroprotective in TBI. In my thesis, the neuroprotective effects of lithium were examined in primary neuronal culture and mild blunt injury using rodent model of Lateral Fluid Percussion Injury (LFPI). At first determination of the neuroprotective/toxicity effects of lithium in neuronal culture was done and observed that 0.5 - 1.0 mM concentrations were found to be neuroprotective as …

Magnetic Field Effects On Lithium Ion Batteries, Kevin Mahon

Theses

The Nobel Prize in Chemistry 2019 was just recently awarded to John B. Goodenough, M. Stanley Whittingham, and Akira Yoshino for the development of lithium-ion batteries. Lithium-ion batteries have seen use in many different industries and applications such as in portable devices, power grids, and electric vehicles. As lithium-ion batteries become more commonplace they will need to be modeled more extensively. The magnetic field effect on lithium-ion batteries has not been studied significantly since they were first discovered.

Modeling these batteries is still difficult because of the many complexities of the operation of a battery. Lithium-ion batteries are commonly modeled …

Modeling, Simulation, And Validation Of Process-Structure-Property Relationships In Fused Filament Fabrication, Aaron Grant

Electronic Theses and Dissertations

As additive manufacturing (AM) grows in popularity, the need for better simulation tools to predict the process-structure-property relationships of AM parts becomes ever more necessary to employ the technology in design of functional parts with varying degrees of complexity and performance requirements. Many simulation tools and techniques have been developed that aim to achieve this goal, and the main purpose of this research is to explore how well different simulation tools and modeling approaches can capture various AM-specific features such as inter-raster and end-of raster voids, and residual stresses induced by dissimilar rates of thermal expansion. Process simulation of fused …

Removel Of Polluntants From Aqueous Solution Via Graphene Oxide/Magnesium Oxide Nanocomposites, Mahdi Heidarizad

Civil and Environmental Engineering Theses and Dissertations

In this study, a series of graphene oxide/magnesium oxide nanocomposites (GO/MgO NCs) were synthesized and applied for the removal of Methylene Blue (MB) from aqueous solutions. The prepared NCs were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The results showed that MgO particles were successfully layered on GO. The impacts of different experimental variables on the removal of MB including GO/MgO NCs dosage, pH, contact time, and initial MB concentration were investigated.

Thereafter, we investigate the mechanism and kinetics of ozonation processes in the presence of GO/MgO NCs as a catalyst …

Evaluation Of The Mechanisms And Effectiveness Of Nano-Hydroxides, Wood And Dairy Manure-Derived Biochars To Remove Fluoride And Heavy Metals From Water, Anna Rose Wallace, Wenjie Sun Dr, Chunming Su Dr

Civil and Environmental Engineering Theses and Dissertations

The development of effective treatment processes for the removal contaminants, such as fluoride and heavy metals, from polluted water have been urgently needed due to serious environmental health and safety concerns. In this dissertation, a variety of materials including various (hydro)oxide nanomaterials, biochars and surface modified biochar were studied to evaluate their effectiveness and mechanism on removing fluoride or mixed heavy metals from water.

In the Chapter 2, this study investigated the adsorptive removal of fluoride from water using various (hydro)oxide nanomaterials, focusing on ferrihydrite, hydroxyapatite (HAP) and brucite, which have the potential to be used as sorbents for surface …

Failure Of High Strength Concrete Under Dynamic Uniaxial Compression, Colin Loeffler

Mechanical Engineering Research Theses and Dissertations

The failure strength of concrete materials has been widely shown to be dependent on experimental parameters such as specimen geometry and strain-rate. The effects of specimen geometry have been shown both theoretically and experimentally to be a result of the quasi-brittle nature of concrete. While the failure strength of concrete has been widely reported to increase significantly when deformed at high strain-rates, the physical mechanisms driving this phenomenon remain the source of debate amongst researchers. This means that constitutive models designed to predict this rate dependent behavior are not based on the real physical mechanisms that drive this behavior but …

Technology-Dependent Quantum Logic Synthesis And Compilation, Kaitlin Smith

Electrical Engineering Theses and Dissertations

The models and rules of quantum computation and quantum information processing (QIP) differ greatly from those that govern classical computation, and these differences have caused the implementation of quantum processing devices with a variety of new technologies. Many platforms have been developed in parallel, but at the time of writing, one method of quantum computing has not shown to be superior to the rest. Because of the variation that exists between quantum platforms, even between those of the same technology, there must be a way to automatically synthesize technology-independent quantum designs into forms that are capable of physical realization on …

Reducing The Production Cost Of Semiconductor Chips Using (Parallel And Concurrent) Testing And Real-Time Monitoring, Qutaiba Khasawneh

Electrical Engineering Theses and Dissertations

Consumer electronics changed the semiconductor industry by developing many new challenges for consumer products. One of the main challenges in the consumer product is that it propelled the volume of production to massive production, e.g. hundreds of millions of cell phones are produced yearly. Combined with the overproduction of consumer products, price pressure is another challenge for consumer products. Many of the new techniques used in the design and fabrication enabled the integration of more devices in the same chips. This reduced the cost of the chips, lowered the power consumption, increased the circuit operation speed, enabled more reliable implementation, …

Utilization Of Low-Lime Calcium Silicate In Hydrated And Carbonated Cementitious Materials, Mohammad Rakibul Islam Khan

Electronic Theses and Dissertations

This study investigated the potential application of wollastonite as a cementitious material in both hydrated and carbonated binder systems. Wollastonite is naturally occurring low-lime calcium silicate (CaO.SiO₂) mineral with a substantially lower carbon footprint compared to the ordinary Portland cement (OPC). The first part of this work presented the application of wollastonite as partial replacement of OPC in traditional hydrated cement-concrete system. Second part of this work evaluated the properties of carbonation activated binder produced using wollastonite as the primary ingredient.

For the first part of the thesis, ground wollastonite with 3.5 µm and 9 µm mean particle …

An Investigation On The Effects Of Cellulose Nanofibrils On The Performance Of Cement Based Composites, Hosain Haddad Kolour

Electronic Theses and Dissertations

Cellulose nanofibrils (CNFs) are hydrophilic biodegradable nanoparticles (typically, less than 0.2 mm in length and 20-50 nm in width) that can be extracted from various plants, trees, and recycled paper stock. Their low density, low toxicity, relatively low cost, high aspect ratio, and high specific surface enable functionalization. In this work, the effects of CNFs on selected properties of cement paste, mortar, and concrete were investigated. For the cement pastes, rheology tests using a simple rheometer showed a reduction in workability as CNF dosage increased. Free shrinkage tests showed an increase in shrinkage at high w/c ratios but a decrease …

Homeostatic Elastic States And The Stability Of Elastic Arteries, Xinyu Zhang

Dissertations - ALL

Vascular mechanics has undergone significant growth within the last 50 years owing to the rapid development of nonlinear continuum mechanics occurring roughly within the same period and motivated primarily by rubber materials. However, one important distinction of blood vessels, in contrast to typical engineering materials is that, through a variety of physiological mechanisms, they seek to maintain constant a preferred mechanical state (mechanical homeostasis) thereby exhibiting a remarkable mechanical stability in response to temporal evolution and alterations in blood pressure, vessel tethering forces and geometry and material properties. The mechanical state experienced by blood vessels plays a critical role in …

Widening Of Reinforced Concrete Bridges – Extension Of Pier Cap Beams With Cfrp Composites, Cheng Tan

Dissertations - ALL

Increase in traffic load dictates widening highway bridges rather than construction of new bridges, as it offers an economical solution. Highway bridge widening is usually accomplished by the construction of additional new bridge piers, however, large amount of construction work and extensive use of heavy plant and machinery could result in very high cost. For limited widening of bridges, e.g. addition of one driving/emergency lane, extension of the pier cap beam offers an attractive solution. Due to additional load resulting from the widened bridge, strengthening of extended cap beams may be needed. In addition, depending on the strength of the …

Network Sampling Through Crawling, Katchaguy Areekijseree

Dissertations - ALL

In recent years, researchers have increasingly used OSN data to study human behavior. Before such a study can begin, one must first obtain appropriate data. A platform, e.g, Facebook or Twitter, may provide an API for accessing data, but such APIs are often ratelimited, restricting the amount of data that an individual collects in a given amount of time. In order for the data collector to efficiently collect data, she needs to make intelligent use of her limited budget. Therefore, when collecting data, efficiency is extremely important. We consider the problem of network sampling through crawling, in which the data …

Novel Shape Memory And Multi-Shape Memory Polymers For Biomaterial Applications, Shelby Lois Buffington

Dissertations - ALL

Biomaterial platforms have been used to probe how cells respond to chemical, topographical or mechanical changes in their environments. However, these traditionally static biomaterial platforms have not enabled the study of how cells respond to dynamic changes in their environment. Driven by a need to better understand cell behavior and its role it disease, development and tissue regeneration recent efforts have focused on designing dynamic biomaterial platforms to better mimic a cell’s natural environment. In this work, advanced shape memory polymers (SMPs) that respond to non-thermal triggers and multi-shape memory materials capable of multiple topographical transitions were developed for advanced …

Status And Remediation Of Mercury In Fish And Aquatic Ecosystems, Geoffrey Dean Millard

Dissertations - ALL

Mercury is a known neurotoxin which can bioaccumulate and biomagnify as methylmercury, causing significant human and ecological impacts. New York State and the surrounding region is impacted by mercury in complex ways as some areas are recovering from the effects of acidic deposition while the entire region is increasingly influenced by climate change. In order to better understand the drivers and trends of mercury dynamics in New York State, my research was conducted in three phases: 1) the impact of lime (calcium carbonate) additions on mercury cycling in small acid-sensitive headwater streams of the Adirondack State Park; 2) applied advanced …

Locating People Of Interest In Social Networks, Pivithuru Wijegunawardana

Dissertations - ALL

By representing relationships between social entities as a network, researchers can analyze them using a variety of powerful techniques. One key problem in social network analysis literature is identifying certain individuals (key players, most influential nodes) in a network. We consider the same problem in this dissertation, with the constraint that the individuals we are interested in identifying (People of Interest) are not necessarily the most important nodes in terms of the network structure. We propose an algorithm to find POIs, algorithms to collect data to find POIs, a framework to model POI behavior and an algorithm to predict POIs …

Network Level Pavement Deterioration Prediction Modeling For The City Of Syracuse, Burak Gursoy

Theses - ALL

Pavement deterioration prediction models play an important role in pavement management systems and allow decision makers to plan maintenance and rehabilitation works in advance. There are several factors affecting the deterioration of pavement sections such as traffic loading, freeze and thaw, snow plowing, construction quality as well as pavement thickness and age. Developing pavement deterioration prediction models can provide decision makers with many benefits. First of all, pavements can be treated before they reach undesired levels of service and this would extend the lifetime. Secondly, required budget for expenses can be provisioned, which helps public authorities to generate more precise …

Spectroscopic Analysis Of The Vanadium Oxide Catalyst During The Ketone Oxidation, Bowei Liu

Theses - ALL

Levulinic acid is a platform chemical that derived by environmental friend biomass. We have previously reported a reaction pathway to transform levulinic acid to maleic anhydride through methyl scission on supported vanadium oxide, which could achieve a 70% yield. The structure of vanadium oxide on the surface of supports can be informative for catalyst selection. We investigated the polymerization of vanadium oxide on support through diffuse reflectance UV-vis spectroscopy. Peak deconvolution of ligand to metal charge transfer region of the spectra provided knowledge of different coordinated structure. All of our catalysts have bulk V2O5 that exists on the surface of …

Numerical Investigation Of Laser-Induced Ignition Phenomena, Deshawn Coombs

Dissertations - ALL

This thesis investigates various aspects of laser-ignition. Laser ignition is a form of combustion initiation by means of a focused laser pulse in a combustible mixture. The ignition process consists of a chain of processes with varying degrees of importance to the prediction of a successful flame propagation. Some of these processes include plasma formation, induced shock wave, emergence of a flame kernel, and successful transition to a self-sustained flame or flame quenching. This thesis will explore various aspects of this process using computational fluid dynamics and model analysis with the aim of identifying the controlling processes and simplified ways …

Sequential Methods For Non-Parametric Hypothesis Testing, Prashant Khanduri

Dissertations - ALL

In today’s world, many applications are characterized by the availability of large amounts of complex-structured data. It is not always possible to fit the data to predefined models or distributions. Model dependent signal processing approaches are often susceptible to mismatches between the data and the assumed model. In cases where the data does not conform to the assumed model, providing sufficient performance guarantees becomes a challenging task. Therefore, it is important to devise methods that are model-independent, robust, provide sufficient performance guarantees for the task at hand and, at the same time, are simple to implement. The goal of this …

Sampling And Characterizing Evolving Communities In Social Networks, Humphrey Appiah Mensah

Dissertations - ALL

One of the most important structures in social networks is communities. Understanding communities is useful in many applications, such as suggesting a friend for a user in an online friendship network, recommending a product for a user in an e-commerce network, etc. However, before studying anything about communities, researchers first need to collect appropriate data. Getting complete access to the data for community studies is unrealistic in most cases. In this work, we address the problem of crawling networks to identify community structure. Firstly, we present a network sampling technique to crawl the community structure of dynamic networks when there …