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Development And Application Of New Methods For Magnetic Resonance Elastography Of The Brain, Charlotte Anne Guertler
Development And Application Of New Methods For Magnetic Resonance Elastography Of The Brain, Charlotte Anne Guertler
McKelvey School of Engineering Theses & Dissertations
Accurate mechanical properties of the intact, living brain are essential for modeling traumatic brain injury (TBI). However, the properties of brain tissue in vivo have traditionally been measured in ex vivo samples. Magnetic resonance elastography (MRE) can be used to measure motion and estimate material properties of soft tissues in vivo, but MRE typically assumes tissue isotropy and homogeneity. The objective of this thesis is to improve MRE of soft tissue, like the brain, by developing and evaluating methods for in vivo estimation of heterogeneous, anisotropic properties. This was achieved through pursuit of the following aims: (1) quantifying the differences …