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Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yijie Ding, Jijun Tang, Fei Guo, Li Peng
Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yijie Ding, Jijun Tang, Fei Guo, Li Peng
Faculty Publications
DNA-binding proteins play an important role in cell metabolism. In biological laboratories, the detection methods of DNA-binding proteins includes yeast one-hybrid methods, bacterial singles and X-ray crystallography methods and others, but these methods involve a lot of labor, material and time. In recent years, many computation-based approachs have been proposed to detect DNA-binding proteins. In this paper, a machine learning-based method, which is called the Fuzzy Kernel Ridge Regression model based on Multi-View Sequence Features (FKRR-MVSF), is proposed to identifying DNA-binding proteins. First of all, multi-view sequence features are extracted from protein sequences. Next, a Multiple Kernel Learning (MKL) algorithm …
Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yije Ding, Jijun Tang, Fei Guo, Li Peng
Fkrr-Mvsf: A Fuzzy Kernel Ridge Regression Model For Identifying Dna-Binding Proteins By Multi-View Sequence Features Via Chou's Five-Step Rule, Yi Zou, Yije Ding, Jijun Tang, Fei Guo, Li Peng
Faculty Publications
DNA-binding proteins play an important role in cell metabolism. In biological laboratories, the detection methods of DNA-binding proteins includes yeast one-hybrid methods, bacterial singles and X-ray crystallography methods and others, but these methods involve a lot of labor, material and time. In recent years, many computation-based approachs have been proposed to detect DNA-binding proteins. In this paper, a machine learning-based method, which is called the Fuzzy Kernel Ridge Regression model based on Multi-View Sequence Features (FKRR-MVSF), is proposed to identifying DNA-binding proteins. First of all, multi-view sequence features are extracted from protein sequences. Next, a Multiple Kernel Learning (MKL) algorithm …
Multivariate Information Fusion With Fast Kernel Learning To Kernel Ridge Regression In Predicting Lncrna-Protein Interactions, Cong Shen, Yijie Ding, Jijun Tang, Fei Guo
Multivariate Information Fusion With Fast Kernel Learning To Kernel Ridge Regression In Predicting Lncrna-Protein Interactions, Cong Shen, Yijie Ding, Jijun Tang, Fei Guo
Faculty Publications
Long non-coding RNAs (lncRNAs) constitute a large class of transcribed RNA molecules. They have a characteristic length of more than 200 nucleotides which do not encode proteins. They play an important role in regulating gene expression by interacting with the homologous RNA-binding proteins. Due to the laborious and time-consuming nature of wet experimental methods, more researchers should pay great attention to computational approaches for the prediction of lncRNA-protein interaction (LPI). An in-depth literature review in the state-of-the-art in silico investigations, leads to the conclusion that there is still room for improving the accuracy and velocity. This paper propose a novel …