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Engineering Commons

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2019

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Medicine and Health Sciences

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Full-Text Articles in Engineering

Generation Of Functional Human Adipose Tissue In Mice From Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany Desouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, Silvia Corvera Jun 2019

Generation Of Functional Human Adipose Tissue In Mice From Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany Desouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, Silvia Corvera

Senior Scholars Program

Adipose tissue (AT) is used extensively in reconstructive and regenerative therapies, but transplanted fat often undergoes cell death, leading to inflammation, calcification, and requirement for further revision surgery. Previously, we have found that mesenchymal progenitor cells within human AT can proliferate in three-dimensional culture under proangiogenic conditions. These cells (primed ADipose progenitor cells, PADS) robustly differentiate into adipocytes in vitro (ad-PADS). The goal of this study is to determine whether ad-PADS can form structured AT in vivo, with potential for use in surgical applications. Grafts formed from ad-PADS were compared to grafts formed from AT obtained by liposuction after implantation ...


Accuracy And Usability Of A Novel Algorithm For Detection Of Irregular Pulse Using A Smartwatch Among Older Adults: Observational Study, Eric Y. Ding, Dong Han, Cody Whitcomb, Syed Khairul Bashar, Oluwaseun Adaramola, Apurv Soni, Jane Saczynski, Timothy P. Fitzgibbons, Majaz Moonis, Steven A. Lubitz, Darleen M. Lessard, Mellanie True Hills, Bruce A. Barton, Ki Chon, David D. Mcmanus May 2019

Accuracy And Usability Of A Novel Algorithm For Detection Of Irregular Pulse Using A Smartwatch Among Older Adults: Observational Study, Eric Y. Ding, Dong Han, Cody Whitcomb, Syed Khairul Bashar, Oluwaseun Adaramola, Apurv Soni, Jane Saczynski, Timothy P. Fitzgibbons, Majaz Moonis, Steven A. Lubitz, Darleen M. Lessard, Mellanie True Hills, Bruce A. Barton, Ki Chon, David D. Mcmanus

Population and Quantitative Health Sciences Publications

BACKGROUND: Atrial fibrillation (AF) is often paroxysmal and minimally symptomatic, hindering its diagnosis. Smartwatches may enhance AF care by facilitating long-term, noninvasive monitoring.

OBJECTIVE: This study aimed to examine the accuracy and usability of arrhythmia discrimination using a smartwatch.

METHODS: A total of 40 adults presenting to a cardiology clinic wore a smartwatch and Holter monitor and performed scripted movements to simulate activities of daily living (ADLs). Participants' clinical and sociodemographic characteristics were abstracted from medical records. Participants completed a questionnaire assessing different domains of the device's usability. Pulse recordings were analyzed blindly using a real-time realizable algorithm and ...