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2019

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Medicine and Health Sciences

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Adjuvant

Articles 1 - 2 of 2

Full-Text Articles in Engineering

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery Of Antigen And Improve Vaccine Efficacy While Inducing Low Inflammation, Sujata Senapati, Ross J. Darling, Darren Loh, Ian C. Schneider, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada Feb 2019

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery Of Antigen And Improve Vaccine Efficacy While Inducing Low Inflammation, Sujata Senapati, Ross J. Darling, Darren Loh, Ian C. Schneider, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada

Chemistry Publications

As the focus has shifted from traditional killed or live, attenuated vaccines towards subunit vaccines, improvements in vaccine safety have been confronted with low immunogenicity of protein antigens. This issue has been addressed by synthesizing and designing a wide variety of antigen carriers and adjuvants, such as Toll-like receptor agonists (e.g., MPLA, CpG). Studies have focused on optimizing adjuvants for improved cellular trafficking, cytosolic availability, and improved antigen presentation. In this work, we describe the design of novel amphiphilic pentablock copolymer (PBC) adjuvants that exhibit high biocompatibility and reversible pH- and temperature-sensitive micelle formation. We demonstrate improved humoral immunity ...


Design And Synthesis Of Multivalent Α-1,2-Trimannose-Linked Bioerodible Microparticles For Applications In Immune Response Studies Of Leishmania Major Infection, Chelsea L. Rintelmann, Tara Grinnage-Pulley, Kathleen Ross, Daniel E. K. Kabotso, Angela Toepp, Anne Cowell, Christine Petersen, Balaji Narasimhan, Nicola Pohl Jan 2019

Design And Synthesis Of Multivalent Α-1,2-Trimannose-Linked Bioerodible Microparticles For Applications In Immune Response Studies Of Leishmania Major Infection, Chelsea L. Rintelmann, Tara Grinnage-Pulley, Kathleen Ross, Daniel E. K. Kabotso, Angela Toepp, Anne Cowell, Christine Petersen, Balaji Narasimhan, Nicola Pohl

Chemical and Biological Engineering Publications

Leishmaniasis, a neglected tropical disease, currently infects approximately 12 million people worldwide with 1 to 2 million new cases each year in predominantly underdeveloped countries. The treatment of the disease is severely underdeveloped due to the ability of the Leishmania pathogen to evade and abate immune responses. In an effort to develop anti-leishmaniasis vaccines and adjuvants, novel carbohydrate-based probes were made to study the mechanisms of immune modulation. In this study, a new bioerodible polyanhydride microparticle was designed and conjugated with a glycodendrimer molecular probe. This molecular probe incorporates a pathogen-like multivalent display of α-1,2-trimannose, for which a more ...