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3d Scaffolds Of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering With Additive Manufacturing And Cellularassessments In A Coculture Of Bone Marrow Stem Cells And Endothelial Cells, Xiaoju Wang, Binbin Zhang, Sanna Pitkanen, Miina Ojansivu, Chunlin Xu, Markus Hannula, Jari A. Hyttinen, Susanna S. Miettinen, Leena Hupa, Gordon G. Wallace
3d Scaffolds Of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering With Additive Manufacturing And Cellularassessments In A Coculture Of Bone Marrow Stem Cells And Endothelial Cells, Xiaoju Wang, Binbin Zhang, Sanna Pitkanen, Miina Ojansivu, Chunlin Xu, Markus Hannula, Jari A. Hyttinen, Susanna S. Miettinen, Leena Hupa, Gordon G. Wallace
Australian Institute for Innovative Materials - Papers
The local delivery of Cu2+ from copper-doped bioactive glass (Cu-BaG) was combined with 3D printing of polycaprolactone (PCL) scaffolds for its potent angiogenic effect in bone tissue engineering. PCL and Cu-BaG were, respectively, dissolved and dispersed in acetone to formulate a moderately homogeneous ink. The PCL/Cu-BaG scaffolds were fabricated via direct ink writing into a cold ethanol bath. The architecture of the printed scaffolds, including strut diameter, strut spacing, and porosity, were investigated and characterized. The PCL/Cu-BaG scaffolds showed a Cu-BaG content-dependent mechanical property, as the compressive Young's modulus ranged from 7 to 13 MPa at an apparent porosity of …