Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 17 of 17

Full-Text Articles in Engineering

Invertebrate Retinal Progenitors As Regenerative Models In A Microfluidic System, Caroline D. Pena, Stephanie Zhang, Robert Majeska, Tadmiri Venkatesh, Maribel Vazquez Oct 2019

Invertebrate Retinal Progenitors As Regenerative Models In A Microfluidic System, Caroline D. Pena, Stephanie Zhang, Robert Majeska, Tadmiri Venkatesh, Maribel Vazquez

Publications and Research

Regenerative retinal therapies have introduced progenitor cells to replace dysfunctional or injured neurons and regain visual function. While contemporary cell replacement therapies have delivered retinal progenitor cells (RPCs) within customized biomaterials to promote viability and enable transplantation, outcomes have been severely limited by the misdirected and/or insuffcient migration of transplanted cells. RPCs must achieve appropriate spatial and functional positioning in host retina, collectively, to restore vision, whereas movement of clustered cells differs substantially from the single cell migration studied in classical chemotaxis models. Defining how RPCs interact with each other, neighboring cell types and surrounding extracellular matrixes are critical ...


Medical Dental Device: Biogeneric Implant Prototype, Ibeth Erazo, Aneeza Hussain, Renata Budny, Gaffar Gailani Oct 2019

Medical Dental Device: Biogeneric Implant Prototype, Ibeth Erazo, Aneeza Hussain, Renata Budny, Gaffar Gailani

Publications and Research

Teeth are lost due to tooth decay, injury, disease, or other causes. Today, dental implants extend the range of care to a variety of patients undergoing necessary prosthodontic rehabilitation. If the benefits of such treatments are to be maximized, then implants must be selected on logical basis and placed within the context of the full range of treatment modalities. However, modern dental implant systems are based on multiple components often leading to micro-movements which cause stress on the bone or bacterial infections, both of which compromise the success of osseointegration and consequently jeopardize the whole implant adaptation. Thus, a new ...


Composite Biomaterial Repair Strategy To Restore Biomechanical Function And Reduce Herniation Risk In An Ex Vivo Large Animal Model Of Intervertebral Disc Herniation With Varying Injury Severity, Warren W. Hom, Melanie Tschopp, Huizi A. Lin, Philip Nasser, Damien M. Laudier, Andrew C. Hecht, Steven B. Nicoll, James C. Iatridis May 2019

Composite Biomaterial Repair Strategy To Restore Biomechanical Function And Reduce Herniation Risk In An Ex Vivo Large Animal Model Of Intervertebral Disc Herniation With Varying Injury Severity, Warren W. Hom, Melanie Tschopp, Huizi A. Lin, Philip Nasser, Damien M. Laudier, Andrew C. Hecht, Steven B. Nicoll, James C. Iatridis

Publications and Research

Back pain commonly arises from intervertebral disc (IVD) damage including annulus fibrosus (AF) defects and nucleus pulposus (NP) loss. Poor IVD healing motivates developing tissue engineering repair strategies. This study evaluated a composite injectable IVD biomaterial repair strategy using carboxymethylcellulose-methylcellulose (CMC-MC) and genipincrosslinked fibrin (FibGen) that mimic NP and AF properties, respectively. Bovine ex vivo caudal IVDs were evaluated in cyclic compression-tension, torsion, and compression-to-failure tests to determine IVD biomechanical properties, height loss, and herniation risk following experimentally-induced severe herniation injury and discectomy (4 mm biopsy defect with 20% NP removed). FibGen with and without CMC-MC had failure strength similar ...


The Effect Of Heterobifunctional Crosslinkers On Hema Hydrogel Modulus And Toughness, Elizabeth M. Boazak, Vaughn K. Greene Jr., Debra T. Auguste May 2019

The Effect Of Heterobifunctional Crosslinkers On Hema Hydrogel Modulus And Toughness, Elizabeth M. Boazak, Vaughn K. Greene Jr., Debra T. Auguste

Publications and Research

The use of hydrogels in load bearing applications is often limited by insufficient toughness. 2-Hydroxyethyl methacrylate (HEMA) based hydrogels are appealing for translational work, as they are affordable and the use of HEMA is FDA approved. Furthermore, HEMA is photopolymerizable, providing spatiotemporal control over mechanical properties. We evaluated the ability of vinyl methacrylate (VM), allyl methacrylate (AM), and 3-(Acryloyloxy)-2-hydroxypropyl methacrylate (AHPM) to tune hydrogel toughness and Young’s modulus. The crosslinkers were selected due to their heterobifunctionality (vinyl and methacrylate) and similar size and structure to EGDMA, which was shown previously to increase toughness as compared to longer ...


The Modeling, Design, Fabrication, And Application Of Biosensor Based On Electric Cell-Substrate Impedance Sensing (Ecis) Technique In Environmental Monitoring, Xudong Zhang, William Wang, Sunghoon Jang Apr 2019

The Modeling, Design, Fabrication, And Application Of Biosensor Based On Electric Cell-Substrate Impedance Sensing (Ecis) Technique In Environmental Monitoring, Xudong Zhang, William Wang, Sunghoon Jang

Publications and Research

In this research, the modeling, design, fabrication, and application of ECIS sensors in environmental monitoringare studied. The ECIS sensors are able to qualify the water toxicity through measuring the cell impedance. A novel mathematical model is proposed to analyze the distribution of electric potential and current of ECIS. This mathematical model is validated by experimental data and can be used to optimize the dimension of ECIS electrodes in order to satisfy environmental monitors. The detection sensitivity of ECIS sensors is analyzed by the mathematical model and experimental data. The simulated and experimental results show that ECIS sensors with smaller radius ...


Bioelectrical Circuits: Lecture 6, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 6, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 2, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 2, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 3, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 3, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 4, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 4, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Msg-Fast: Metagenomic Shotgun Data Fast Annotation Using Microbial Gene Catalogs, Stuart M. Brown, Hao Chen, Yuhan Hao, Bobby P. Laungani, Thahmina A. Ali, Changsu Dong, Carlos Lijeron, Baekdoo Kim, Claudia Wultsch, Zhiheng Pei, Konstantinos Krampis Jan 2019

Msg-Fast: Metagenomic Shotgun Data Fast Annotation Using Microbial Gene Catalogs, Stuart M. Brown, Hao Chen, Yuhan Hao, Bobby P. Laungani, Thahmina A. Ali, Changsu Dong, Carlos Lijeron, Baekdoo Kim, Claudia Wultsch, Zhiheng Pei, Konstantinos Krampis

Publications and Research

Background: Current methods used for annotating metagenomics shotgun sequencing (MGS) data rely on a computationally intensive and low-stringency approach of mapping each read to a generic database of proteins or reference microbial genomes.

Results: We developed MGS-Fast, an analysis approach for shotgun whole-genome metagenomic data utilizing Bowtie2 DNA-DNA alignment of reads that is an alternative to using the integrated catalog of reference genes database of well-annotated genes compiled from human microbiome data. This method is rapid and provides high-stringency matches (>90% DNA sequence identity) of the metagenomics reads to genes with annotated functions. We demonstrate the use of this method ...


Bme 20500 Bioelectrical Circuits, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bme 20500 Bioelectrical Circuits, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 10, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 10, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 9, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 9, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 7, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 7, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 1, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 1, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 5, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 5, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.


Bioelectrical Circuits: Lecture 8, Jacek P. Dmochowski, Luis Cardoso Jan 2019

Bioelectrical Circuits: Lecture 8, Jacek P. Dmochowski, Luis Cardoso

Open Educational Resources

No abstract provided.