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Full-Text Articles in Engineering

Minimalistic Peptide-Based Supramolecular Systems Relevant To The Chemical Origin Of Life, Daniela Kroiss Sep 2019

Minimalistic Peptide-Based Supramolecular Systems Relevant To The Chemical Origin Of Life, Daniela Kroiss

All Dissertations, Theses, and Capstone Projects

All forms of life are based on biopolymers, which are made up of a selection of simple building blocks, such as amino acids, nucleotides, fatty acids and sugars. Their individual properties govern their interactions, giving rise to complex supramolecular structures with highly specialized functionality, including ligand recognition, catalysis and compartmentalization. In this thesis, we aim to answer the question whether short peptides could have acted as precursors of modern proteins during prebiotic evolution. Using a combination of experimental and computational techniques, we screened a large molecular search space for peptide sequences that are capable of forming supramolecular complexes with adenosine ...


Renal Specific Rnai Delivery By Fibrillar Nanoparticle Excipients, Sam Wong Sep 2019

Renal Specific Rnai Delivery By Fibrillar Nanoparticle Excipients, Sam Wong

All Dissertations, Theses, and Capstone Projects

RNA interference (RNAi) is a powerful tool to manipulate the phenotype of an organism by silencing the expression of specific genes and is viewed as a highly promising platform for treating undruggable targets and disorders where small molecule drugs and antibodies would fail. However, development of RNAi based therapies has faced major barriers including cellular and tissue-specific uptake of the Small Interfering RNA (siRNA). Utilizing different nanoparticles as RNAi excipients, cellular uptake and gene silencing potency can be greatly improved. The research in Dr. McDevitt groups has fibrillar carbon nanotubes (CNT) as carriers for siRNA for gene silencing in vitro ...


A Purely Defeasible Argumentation Framework, Zimi Li May 2019

A Purely Defeasible Argumentation Framework, Zimi Li

All Dissertations, Theses, and Capstone Projects

Argumentation theory is concerned with the way that intelligent agents discuss whether some statement holds. It is a claim-based theory that is widely used in many areas, such as law, linguistics and computer science. In the past few years, formal argumentation frameworks have been heavily studied and applications have been proposed in fields such as natural language processing, the semantic web and multi-agent systems. Studying argumentation provides results which help in developing tools and applications in these areas. Argumentation is interesting as a logic-based approach to deal with inconsistent information. Arguments are constructed using a process like logical inference, with ...


Fashion Merchandising: An Augmented Reality, Naeha A. Sayed May 2019

Fashion Merchandising: An Augmented Reality, Naeha A. Sayed

All Dissertations, Theses, and Capstone Projects

There is a continuous and constant transformation in the field of Augmented Reality (AR), both in the Retail, and the Manufacturing sector. It has started to influence everything from fashion runway shows to online shopping. Consumers dynamics have shifted in the fashion industry, the ways becoming more dominant than the old observant ones- the simple buying experience no longer satisfies them. Due to the emergence of the new digital platforms and technological enhancements, the consumers are looking for more- be it a more exciting buying experience or more user interaction or more enhanced products. This technological change starts with the ...


Efficient Private Information Retrieval, Konstantinos Nikolopoulos May 2019

Efficient Private Information Retrieval, Konstantinos Nikolopoulos

All Dissertations, Theses, and Capstone Projects

A vast amount of today's Internet users' on line activities consists of queries to various types of databases. From traditional search engines to modern cloud based services, a person's everyday queries over a period of time on various data sources, will leave a trail visible to the query processor, which can reveal significant and possibly sensitive information about her. Private Information Retrieval (PIR) algorithms can be leveraged for providing perfect privacy to users' queries, though at a restrictive computational cost. In this work, we consider today's highly distributed computing environments, as well as certain secure-hardware devices, for ...


Using Transfer Learning In Network Markets, Kai Cai May 2019

Using Transfer Learning In Network Markets, Kai Cai

All Dissertations, Theses, and Capstone Projects

Mechanism design is the sub-field of microeconomics and game theory, which considers agents have their own private information and are self-interested and tries to design systems that can produce desirable outcomes. In recent years, with the development of internet and electronic markets, mechanism design has become an important research field in computer science. This work has largely focused on single markets. In the real world, individual markets tend to connect to other markets and form a big “network market”, where each market occupies a node in the network and connections between markets reflect constraints on traders in the markets. So ...