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Full-Text Articles in Engineering

Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts Aug 2019

Bioengineering Extracellular Matrix Scaffolds For Volumetric Muscle Loss, Kevin Roberts

Theses and Dissertations

Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in fibrosis and severe functional deficits which have defied clinical repair strategies. My work spans the design and preclinical evaluation of implants intended to drive the cell community of injured muscle toward a regenerative state, as well as the development of an understanding of the molecular responses of this cell community to biomaterial interventions. I demonstrate a new class of biomaterial by leveraging the productive capacity of sacrificial hollow fiber membrane cell culture; I show specifically that unique threads of whole extracellular matrix can be isolated by solvent ...


Chemical And Physical Modification Of Thiol-Ene And Epoxy-Amine Networks For Advanced Control Of Gas Transport And Flame Retardant Behavior, Vivek Vasagar May 2019

Chemical And Physical Modification Of Thiol-Ene And Epoxy-Amine Networks For Advanced Control Of Gas Transport And Flame Retardant Behavior, Vivek Vasagar

Dissertations

Crosslinked polymers are widely used due to its several advantages not limited to high mechanical strength combined with the easy processability. Despite of its popular usage, the fundamental understanding of polymer structure affecting the desired properties is still lacking. This PhD thesis is in two parts, the first part is devoted to the design and developing a basic understanding of structure and chemical composition dependencies of gas transport, whereas in the second part a fundamental relationship between structure to the fire-retardant properties is established.

Membrane based gas separation technique has attracted interest of selective removal of carbon dioxide gas from ...


Progress Report I: Fabrication Of Nanopores In Silicon Nitride Membranes Using Self-Assembly Of Ps-B-Pmma, Unnati Joshi, Vishal Venkatesh, Hiromichi Yamamoto Mar 2019

Progress Report I: Fabrication Of Nanopores In Silicon Nitride Membranes Using Self-Assembly Of Ps-B-Pmma, Unnati Joshi, Vishal Venkatesh, Hiromichi Yamamoto

Protocols and Reports

This progress report describes fabrication of silicon nitride membranes from Si wafers using cleanroom techniques, and of nanopore preparation via a self-assembled PS-b-PMMA film. A 36.9 µm thick membrane is successfully prepared by KOH wet etching. The membrane is a layered structure of 36.8 µm thick Si and 116 nm thick silicon nitride. It is also exhibited that in the 47 nm thick PS-b-PMMA film, the nanopore structure is observed in the vicinity of a dust particle, but most of the area indicates lamellar domain structure. The thickness of PS-b-PMMA film will ...


Improving Performance Of Infiltrated Sofc Cathodes Via Scaffold Engineering And Catalyst Surface Engineering, Yuan Cheng Jan 2019

Improving Performance Of Infiltrated Sofc Cathodes Via Scaffold Engineering And Catalyst Surface Engineering, Yuan Cheng

Publicly Accessible Penn Dissertations

Solid Oxide Fuel Cells (SOFCs) are energy-generating devices operating at elevated temperatures. At their cathode sides, oxygen molecules reduce into oxygen ions and then transport to the anode side through a solid-state ceramic membrane (typically, Yttria-Stabilized Zirconia (YSZ)). At their anode side, the fuels react with the oxygen ions and then release electrons to the external circuit. Always, it is the cathode that has the slowest reaction kinetics, such it contributes the largest resistance in the entire device.

The state-of-the-art cathode materials are typically perovskite-phase ceramic materials, such as Strontium-doped Lanthanum Manganate (LSM), Strontium-doped Lanthanum Ferrite (LSF) and Strontium-doped Lanthanum ...