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Full-Text Articles in Engineering

Study On Antibacterial Of Chitosan/Hydroxyapatite Doped Magnesium Composite As A Material For Bone Graft Applications, Andromeda Dwi Laksono, Teodoro A. Amatosa, Jr., Hilda Pebrianti Octaviana Sitorus, Wentika Putri Kusuma Asih, Sulistijono Sulistijono Dec 2019

Study On Antibacterial Of Chitosan/Hydroxyapatite Doped Magnesium Composite As A Material For Bone Graft Applications, Andromeda Dwi Laksono, Teodoro A. Amatosa, Jr., Hilda Pebrianti Octaviana Sitorus, Wentika Putri Kusuma Asih, Sulistijono Sulistijono

Makara Journal of Technology

Hydroxyapatite (HAp) is one of the constituent minerals of bone and teeth, that has been widely used for synthesizing bone graft. Due to the limitation on properties of the hydroxyapatite, it is doping with Magnesium (HAp-Mg). The addition of Chitosan (Chi) was expected to improve the antibacterial properties of HAp-Mg. The present research aims to study the influence of Chitosan with 0, 5, 15, and 25 wt% addition on biocompatibility properties of Chi/HAp-Mg composite. HAp-Mg was synthesized using the sol-gel method; meanwhile, Chi/HAp-Mg composite was manufactured by mixing Chitosan in acetic acid, and HAp-Mg was added into the ...


Electrospinning Nanofibers From Chitosan-Hyaluronic Acid Complex Coacervates, Juanfeng Sun Aug 2019

Electrospinning Nanofibers From Chitosan-Hyaluronic Acid Complex Coacervates, Juanfeng Sun

Masters Theses

Electrospun nanofibers have been used for many applications, but a reliance on organic solvents limits their use in biomedical fields. In this study, we successfully electrospun nanofibers from aqueous chitosan-hyaluronic acid complex coacervates. We studied how solvent’ properties affected the average nanofiber diameter by using pure water as a solvent versus ethanol-water solutions. Experimentally, we investigated the effect of electrospinning apparatus parameters, such as how the applied voltage affected fiber formation and morphology. The smallest average nanofiber diameter was determined to be around 115 ± 30 nm when 3 wt% ethanol coacervate samples were electrospun using the applied voltage of 24 ...


Synthesis, Characterization And Selected Application Of Chitosan-Coated Magnetic Iron Oxide Nanoparticles, Hany A. Elazab Dr Aug 2019

Synthesis, Characterization And Selected Application Of Chitosan-Coated Magnetic Iron Oxide Nanoparticles, Hany A. Elazab Dr

Chemical Engineering

In this research, we report an efficient method to prepare highly active chitosan-coated magnetic iron oxide nanoparticles by implementing co-precipitation technique which is used for waste water treatment applications. Chitosan-coated magnetic iron oxide nanoparticles were synthesized and characterized using TEM, XRD, and XPS. A comparative study has been made between chitosan powder and chitosan coated with magnetic nanoparticles with respect to the rate of adsorption of copper from aqueous solution. It was also experimentally verified that chitosancoated magnetic iron oxide nanoparticles are much more effective in adsorption of heavy metals than chitosan powder and it takes just few minutes instead ...


A Ph-Sensitive Delivery System For The Prevention Of Dental Caries Using Salivary Proteins, Yi Zhu May 2019

A Ph-Sensitive Delivery System For The Prevention Of Dental Caries Using Salivary Proteins, Yi Zhu

Electronic Thesis and Dissertation Repository

Dental caries remains one of the most common chronic diseases worldwide. Salivary proteins such as histatins have demonstrated biological functions directly related to tooth homeostasis and prevention of dental caries. However, histatins are susceptible to the high proteolytic activities in the oral environment. Therefore, pH-sensitive chitosan nanoparticles (CNs) have been proposed as potential carriers to target major oral diseases that occur under acidic conditions (e.g. dental caries and dental erosion). Four different types of chitosan polymers were investigated and the optimized CNs successfully loaded histatin 3 and released it selectively under acidic conditions. Through loading the survival time of ...


Multistage Sonication Effect On The Composition And Properties Of Degraded Chitosan Product, Nurul Laili Arifin, Emma Savitri, Anjar Indah, Fesa Putra, Sumarno Sumarno Apr 2019

Multistage Sonication Effect On The Composition And Properties Of Degraded Chitosan Product, Nurul Laili Arifin, Emma Savitri, Anjar Indah, Fesa Putra, Sumarno Sumarno

Makara Journal of Technology

The sonication method randomly breaks polymer chains to produce a varied distribution of products. A scheme with multi-stage sonication steps is proposed to identify oligomers and low molecular weight chitosan based on changes to the degrad-ed product. For each sonication level, 1% (w/v) chitosan in 1% (v/v) aqueous acetic acid was sonicated for 120 min at 60 °C. The products of the sonication treatment were deprotonized by adding an alkali solution, freeze dried and insoluble product re-sonicated until a low molecular weight was produced. Low molecular weight chitosan/insoluble products were character-ized with Fourier-transform infrared spectra (FT-IR) and ...


Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine Jan 2019

Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine

Williams Honors College, Honors Research Projects

The main objective of this honor’s project is to encapsulate drugs with different molecular weights inside of chitosan-heparin based nanoparticles (Cs-Hep NPs). Three different drugs with low (NNC), medium (IFN-γ), and large (BSA) molecular weights were chosen in order to compare all types of drugs and how they react with the nanoparticles. Analysis of particle size, zeta potential, and a release study was performed. The release took place over a 168-hour time period and liquid samples were taken throughout. The hypothesis was that the molecular weight of the drug will correlate to the physical properties of the nanoparticles. The ...