Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Impact Of Stirrer Speed And Media Type-Loading On The Breakage Kinetics During Wet Stirred Media Milling Of Griseofulvin, Nathaniel Parker
Impact Of Stirrer Speed And Media Type-Loading On The Breakage Kinetics During Wet Stirred Media Milling Of Griseofulvin, Nathaniel Parker
Theses
The aim of this study is to investigate the impact of stirrer speed (2000-4000 rpm) and bead loading (~20-60%) on the breakage kinetics-energy consumption during milling of griseofulvin, a poorly soluble drug, and compare the performance of crosslinked polystyrene (CPS) beads with that of yttrium-stabilized zirconia (YSZ) beads. Laser diffraction, SEM, viscometry, and XRPD were used for characterization. A microhydrodynamic model was used to interpret the breakage kinetics. An increase in stirrer speed led to faster breakage due to more frequent and forceful CPS bead-bead collisions. Despite causing slight decrease in maximum contact pressure, an increase in CPS bead loading …