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Articles 1 - 2 of 2
Full-Text Articles in Engineering
3d Printed Polypyrrole Scaffolds For Ph Dependent Drug Delivery With Applications In Bone Regeneration, Matthew T. Lawrence
3d Printed Polypyrrole Scaffolds For Ph Dependent Drug Delivery With Applications In Bone Regeneration, Matthew T. Lawrence
Electronic Thesis and Dissertation Repository
Areas of large bone loss are typically healed using autologous bone grafts, seen as the gold standard of care. These materials have a complication rate of 10–40% during harvesting and are limited by the quantity available; therefore the use of 3D printed polymer scaffolds as bone graft alternatives are proposed. Polypyrrole (PPy) is a biocompatible electroactive polymer that has metal-like electrical properties that can be harnessed to hold and release charged drug molecules, triggered by a change in pH. pH fluctuations are seen inside the human body in areas of bone regrowth, which would act as the triggering mechanism for …
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Development Of Light Actuated Chemical Delivery Platform On A 2-D Array Of Micropore Structure, Hojjat Rostami Azmand, Hojjat Rostami Azmand
Dissertations and Theses
Localized chemical delivery plays an essential role in the fundamental information transfers within biological systems. Thus, the ability to mimic the natural chemical signal modulation would provide significant contributions to understand the functional signaling pathway of biological cells and develop new prosthetic devices for neurological disorders. In this paper, we demonstrate a light-controlled hydrogel platform that can be used for localized chemical delivery in a high spatial resolution. By utilizing the photothermal behavior of graphene-hydrogel composites confined within micron-sized fluidic channels, patterned light illumination creates the parallel and independent actuation of chemical release in a group of fluidic ports. The …