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Design And Development Of A Ventilation Chamber For Testing Efficacy Of Tracheal Stents, Caroline N. Horton
Design And Development Of A Ventilation Chamber For Testing Efficacy Of Tracheal Stents, Caroline N. Horton
Theses and Dissertations
Tracheobronchial malacia results in a weakening of the tracheal walls, leading to increased difficulty breathing. Stents are used to reopen the lumen of the trachea, however, current models are not personalized to each patient, leading to migration, inflammation, and breakage of the stents. In order to successfully test novel stent designs, a ventilation chamber is needed to recreate the breathing conditions of the body.
The following describes the iterative development of a ventilation chamber, which allows inflation and deflation of lungs via negative pressure ventilation, as representative of an actual body undergoing respiration. Previous work shows that lungs are not …
Material Considerations For Development Of 3d Printed Bronchial And Tracheal Stents, Nidah M. Hussain
Material Considerations For Development Of 3d Printed Bronchial And Tracheal Stents, Nidah M. Hussain
Theses and Dissertations
Tracheobronchial malacia is a commonly under-diagnosed condition that results in difficulty breathing. The use of a tracheobronchial stent is the best course of treatment for patients whose quality of life has deteriorated due to malacia; unfortunately stents need replacing after issues with inflammation, migration, or eventual stent-breakdown resulting in fistula formation.
The purpose of this thesis is to use three-dimensional (3D) printing technology to improve on existing stents through designing and printing a bioresorbable/biodegradable tracheobronchial stent that can treat tracheobronchial malacia. This was undertaken by testing three biologically favorable materials, type I collagen, polycaprolactone (PCL), and thermoplastic polyurethane (TPU), with …