Engineering Commons^™

Characterizing The Effects Of Repetitive Head Trauma In Female Soccer Athletes For Prevention Of Mild Traumatic Brain Injury, Diana Otero Svaldi

Open Access Dissertations

As participation in women’s soccer continues to grow and the longevity of female athletes’ careers continues to increase, prevention of mTBI in women’s soccer has become a major concern for female athletes as the long-term risks associated with a history of mTBI are well documented. Among women’s sports, soccer exhibits the highest concussion rates, on par with those of men’s football at the collegiate level. Head impact monitoring technology has revealed that “concussive hits” occurring directly before symptomatic injury are not predictive of mTBI, suggesting that the cumulative effect of repetitive head impacts experienced by collision sport athletes should be …

Evaluating The Two-Stage Ditch As A New Best Management Practice, Andi Hodaj

Open Access Dissertations

A two-stage ditch involves modifications of a traditional drainage ditch to resemble more the features of a natural stream. The idea is to create or simulate extended benches on both sides of the ditch that would develop naturally over a period of time in a stream because of geomorphological processes. Previous research in Indiana and Ohio has shown that two-stage ditches offer the potential to reduce sediment load and extend the interaction time between water and vegetation on the benches allowing larger uptake of nutrients from the vegetation on the extended benches, and increasing the denitrification rates in the bench …

X-Ray Fluorescence For Quantification Of Lead And Strontium In Vivo, Aaron James Specht

Open Access Dissertations

Lead (Pb) is a toxicant well known for its effects on almost every organ system in the body. Pb use in industry has declined since removal of Pb from gasoline, but many developing countries still have significant use of Pb. Exposure to Pb has been linked with diseases causing neurodegeneration and thus have lasting effects long after the initial exposure. Another metal, strontium (Sr), has been linked with bone disease in particular situations and shown to have uses in treating osteoporosis as a supplement. However, there are no studies of the effects of Sr using a meaningful biomarker. The most …

Is Metabolism Goal-Directed? Investigating The Validity Of Modeling Biological Systems With Cybernetic Control Via Omic Data, Frank T. Devilbiss

Open Access Dissertations

Cybernetic models are uniquely juxtaposed to other metabolic modeling frameworks in that they describe the time-dependent regulation of cellular reactions in terms of dynamic "metabolic goals." This approach contrasts starkly with purely mechanistic descriptions of metabolic regulation which seek to explain metabolic processes in high resolution — a clearly daunting undertaking. Over a span of three decades, cybernetic models have been used to predict metabolic phenomena ranging from resource consumption in mixed-substrate environments to intracellular reaction fluxes of intricate metabolic networks. While the cybernetic approach has been validated in its utility for the prediction of metabolic phenomena, its central feature, …

Influence Of The 3d Microenvironment On Glioblastoma Migration And Drug Response, Ruth Marisol Herrera Perez

Open Access Dissertations

Glioblastoma (GBM) is a highly invasive brain cancer characterized by poor prognosis. Despite significant efforts by the basic and clinical research community our understanding of GBM progression and recurrence has been incremental. Improvements in therapeutic response have been dismal, and GBM continues to be the deadliest tumor of the central nervous system, with patient average survival rate of 12 months. Synergistic relationships that the tumor cells establish with the brain microenvironment have been proven fundamental for successful tumor progression and maintenance. Yet, many in vitro GBM studies are performed in formats that fail to recapitulate the most essential component of …

Enhancing Bioethanol Fermentation Through Removal Of Acetic Acid Using Liquid-Liquid Extraction, Mahdieh Aghazadeh

Open Access Dissertations

The concern for the ever growing human population as well as the depletion of fossil fuel resources and their impact on global warming have long been motivations for the researchers to investigate means for sustainable producing carbon-neutral energy. Second-generation biofuel refers to liquid fuels that are produced from non-food resources and reduce the total greenhouse gas emission by at least 60 %. Acetic acid has been shown to be one of the most ubiquitous fermentation inhibitors in a bioethanol production facility which slows down the bioethanol production and reduces its yield through inhibition of the ethanol producing microorganisms. The use …

Hydrologic And Water Quality Impacts From Perennial Crop Production On Marginal Lands, Qingyu Feng

Open Access Dissertations

Marginal lands are proposed as a viable option for producing biofeedstocks as these lands are not heavily engaged in agricultural production or may not be suitable for intensive row-crop food/feed production. However, meeting biofeedstock production goals will require large amount of marginal lands and the unintended consequences of producing biofeedstocks on marginal lands are not fully clear. The overall goal of this study was to evaluate the productivity of biofeedstocks on marginal lands and the potential impacts on hydrologic and water quality processes from the land use conversion.

This study was conducted in the Upper Mississippi River Basin (UMRB). First, …