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Studies On Nanocomposite Coating Produced By Laser-Assisted Process To Prevent Silicone Hydrogels From Bio-Fouling, Vishnuvardhana Wuppaladhodi
Studies On Nanocomposite Coating Produced By Laser-Assisted Process To Prevent Silicone Hydrogels From Bio-Fouling, Vishnuvardhana Wuppaladhodi
Electronic Thesis and Dissertation Repository
In this thesis, silver nanoparticles incorporated into polyvinylpyrrolidone (PVP) were deposited on silicone hydrogel to improve the hydrophilicity of the silicone hydrogel and prevent the growth of bacteria. Two different processes were employed to produce Ag nanoparticles: (1) Process-A is a photochemical reduction; (2) Process-B is laser ablation in liquid. Following that, MAPLE process was employed to deposit the Ag-PVP nanocomposites on the surface of silicone hydrogel. A solid-state pulsed laser (Nd:YAG) with a wavelength of 532 nm at a fluence of 50.4 mJ/cm2 was used in the MAPLE system to deposit Ag-PVP nanocomposite coating. Our results indicate that …
Hydrogel-Based Nanocomposites And Laser-Assisted Surface Modification For Biomedical Application, Pei Yin
Hydrogel-Based Nanocomposites And Laser-Assisted Surface Modification For Biomedical Application, Pei Yin
Electronic Thesis and Dissertation Repository
Hydrogels can be used in contact lens, wound dressing, drug delivery and tissue scaffolds due to their good biocompatibility. However, the poor mechanical properties and non-specific protein adsorption of hydrogels limit their applications. The adverse effects of protein adsorption in hydrogels include biofouling, inflammation, or even body rejection. In this project, two different hydrogel materials, co-polymer 2-hydroxyethyl methacrylate with a low amount of 2-aminoethyl methacrylate, p(HEMA-co-AEMA) and silicone hydrogel were fabricated by photo-polymerization; the former has hydrophilic surface and the latter is hydrophobic. The silica (SiO2) nanoparticle-loaded hydrogels have been developed by using in situ polymerization. The dispersion …