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Polymeric Superparamagnetic Nanoparticles For Drug Delivery Applications, Leena Mohammed
Polymeric Superparamagnetic Nanoparticles For Drug Delivery Applications, Leena Mohammed
Electronic Thesis and Dissertation Repository
Drug delivery systems based on magnetic nanoparticles present a promising avenue for controlled targeted therapeutics, especially in cancer therapy. Conventional systematic therapeutics encompasses numerous side effects due to its limited selectivity between healthy and cancerous cells. In this thesis, novel polymeric-metallic hybrid nanoaggregates were developed to address this challenge. Magnetite nanoparticles were synthesized via precipitation of iron oxide and was surface modified using a unique chitosan derivative, glycol chitosan (GC), loaded with progesterone for potential hormonal therapy application for breast cancer. Surface characterizations techniques, in vitro drug release kinetics, investigation of progesterone release mechanism by mathematical modeling, and cell cytotoxicity …
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Electronic Thesis and Dissertation Repository
The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited a slower …