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Doctoral Dissertations

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Full-Text Articles in Engineering

Two And Three-Dimensional Models For Material And Cells Interaction, Nam H. Nguyen May 2019

Two And Three-Dimensional Models For Material And Cells Interaction, Nam H. Nguyen

Doctoral Dissertations

Three-dimensional (3D) cell spheroid model has been long considered a better model to mimic in vivo physiology compared to two-dimensional (2D) cell culture model. Traditional 2D cell models provide a simple, convenient and quick technique for drug screening but fail to simulate the complexity and heterogeneity of cells in the in vivo environment. The last few decades have remarked substantial progress toward the advancement of three-dimensional (3D) cell cultures as systems which better mimic cellcell and cell-matrix interaction in the in vivo physiology. Nowadays, 3D cell models have been emerging, not only as an important approach in drug discovery and ...


Evaluation Of Carbon Footprint During The Life-Cycle Of Four Different Pipe Materials, Alhossin Alsadi May 2019

Evaluation Of Carbon Footprint During The Life-Cycle Of Four Different Pipe Materials, Alhossin Alsadi

Doctoral Dissertations

As the world is moving to provide a better and cleaner environment for future generations, there is a critical need to quantify and try to reduce the environmental emission footprints of various industries. The construction industry, which emits a large amount of carbon dioxide (CO₂ ), is one of the targeted industries to decrease these emissions. Underground utility installations, especially in the development of residential communities in urban areas, are one of the largest construction projects across North America and, consequently, one primary source of emissions. Most of the pipelines in the U.S. are rapidly reaching the end of their ...


Development Of An Astrocyte/Glioma Co-Culture System For Measuring Cellular Dynamics, Urna Kansakar Feb 2019

Development Of An Astrocyte/Glioma Co-Culture System For Measuring Cellular Dynamics, Urna Kansakar

Doctoral Dissertations

Gliomas are brain tumors that primarily arise from glial cells. Gliomas account for 70% of the brain tumors and they are more prevalent in older adults. About 60% of the people with gliomas experience at least one seizure. Brain tumors can grow and metastasize to neighboring areas, thereby destroying normal brain cells. In a brain tumor microenvironment, both malignant cancer cells and healthy brain cells are present. Studies have shown that astrocytes may have a role in tumor growth in the brain. Monocultures cannot evaluate interactions between two cell types and does not accurately represent in vivo conditions. Thus, a ...


Development Of A Counter-Flow Thermal Gradient Microfluidic Device, Shayan Davani Feb 2019

Development Of A Counter-Flow Thermal Gradient Microfluidic Device, Shayan Davani

Doctoral Dissertations

This work presents a novel counter-flow design for thermal stabilization of microfluidic thermal reactors. In these reactors, precise control of temperature of the liquid sample is achieved by moving the liquid sample through the thermal zones established ideally through the conduction in the solid material of the device. The goal here is to establish a linear thermal distribution when there is no flow and to minimize the temperature change at flow condition. External convection as well as internal flowinduced effects influence the prescribed thermal distribution. The counter-flow thermal gradient device developed in this study is capable of both stabilizing the ...


Mechanical Performance Of Structural Systems With Missing Members: From Buildings To Architected Materials, Panagiotis Pantidis Jan 2019

Mechanical Performance Of Structural Systems With Missing Members: From Buildings To Architected Materials, Panagiotis Pantidis

Doctoral Dissertations

Structural systems are potentially subjected to damage initiating scenarios throughout the course of their service time. Depending on the nature and extent of the damaging event, they may experience significant reduction or even complete loss of their mechanical performance. This dissertation delves into the mechanics of structural systems under the notion of missing members from their domain, investigating types of structural systems: a) multi-story steel framed buildings, and b) materials with a truss-lattice microstructure.

Part I of the dissertation investigates the performance of multi-story steel framed buildings under a column removal scenario, developing an analytical framework for their quasi-static robustness ...


Three Essays On Data-Driven Optimization For Scheduling In Manufacturing And Healthcare, Ekin Koker Jan 2019

Three Essays On Data-Driven Optimization For Scheduling In Manufacturing And Healthcare, Ekin Koker

Doctoral Dissertations

This dissertation consists of three essays on data-driven optimization for scheduling in manufacturing and healthcare. In Chapter 1, we briefly introduce the optimization problems tackled in these essays. The first of these essays deals with machine scheduling problems. In Chapter 2, we compare the effectiveness of direct positional variables against relative positional variables computationally in a variety of machine scheduling problems and we present our results. The second essay deals with a scheduling problem in healthcare: the team primary care practice. In Chapter 3, we build upon the two-stage stochastic integer programming model introduced by Alvarez Oh (2015) to solve ...


Service Competition And Data-Centric Protocols For Internet Access, Thiago Teixeira Jan 2019

Service Competition And Data-Centric Protocols For Internet Access, Thiago Teixeira

Doctoral Dissertations

The Internet evolved in many aspects, from the application to the physical layers. However, the evolution of the Internet access technologies, most visible in dense urban scenarios, is not easily noticeable in sparsely populated and rural areas.

In the United States, for example, the FCC identified that 50% of the census blocks have access to up to two broadband providers; however, these providers do not necessarily compete. Additionally, due to the methodology of the study, there is evidence that the number of actual customers without broadband access is higher since the FCC considers the entire block to have broadband if ...


Software-Defined Infrastructure For Iot-Based Energy Systems, Stephen Lee Jan 2019

Software-Defined Infrastructure For Iot-Based Energy Systems, Stephen Lee

Doctoral Dissertations

Internet of Things (IoT) devices are becoming an essential part of our everyday lives. These physical devices are connected to the internet and can measure or control the environment around us. Further, IoT devices are increasingly being used to monitor buildings, farms, health, and transportation. As these connected devices become more pervasive, these devices will generate vast amounts of data that can be used to gain insights and build intelligence into the system. At the same time, large-scale deployment of these devices will raise new challenges in efficiently managing and controlling them.

In this thesis, I argue that the IoT ...


Amorphous-Crystalline Brush Block Copolymers: Phase Behavior, Rheology And Composite Design, Gayathri Kopanati Jan 2019

Amorphous-Crystalline Brush Block Copolymers: Phase Behavior, Rheology And Composite Design, Gayathri Kopanati

Doctoral Dissertations

Bottlebrush block copolymers are polymers with chemically distinct polymer side chains grafted onto a common backbone. The unique architecture induced properties make these materials attractive for applications such as photonic materials, stimuli responsive actuators and drug delivery vehicles to name a few. This dissertation primarily investigates the phase transitions and rheological behavior of amorphous-crystalline bottlebrush brush block copolymers and their composites. The temperature induced phase behavior is investigated using time resolved synchrotron X-ray source. Irrespective of volume fraction and backbone length, the samples display strong segregation even at high temperatures (200 °C) and there is no accessible order-disorder transition in ...


Top-Down And Bottom-Up Fabrication Of Key Components In Miniature Energy Storage Devices, Wenhao Li Jan 2019

Top-Down And Bottom-Up Fabrication Of Key Components In Miniature Energy Storage Devices, Wenhao Li

Doctoral Dissertations

The advent of miniature electronic devices demands power sources of commensurate form factors. This spurs the research of micro energy storage devices, e.g., 3D microbatteries. A 3D microbattery contains nonplanar microelectrodes with high aspect ratio and high surface area, separated by a nanoscale electrolyte. The device takes up a total volume as small as 10 mm3, allowing it to serve on a chip and to provide power in-situ. The marriage of nanotechnology and electrochemical energy storage makes microbattery research a fascinating field with both scientific excitement and application prospect. However, successful fabrication of well-functioned key components and the ...


Self-Exfoliating And Reactive Polymer (Serp) As A Protection Against Chemical Warfare Agents (Cwas), Soeun Kim Jan 2019

Self-Exfoliating And Reactive Polymer (Serp) As A Protection Against Chemical Warfare Agents (Cwas), Soeun Kim

Doctoral Dissertations

According to the US army report, there are still significant numbers of stockpiles of chemical warfare agents (CWAs) produced during the Second World War. CWAs production and stockpiling were officially outlawed by the Chemical Weapons Convention of 1993. Nevertheless, some fanatics around the world use CWA as a weapon of mass destruction, such as the Sarin gas attack in Syria in 2013. Since the discovery that toxic pentavalent organophosphorus (OP) compounds has facilitated the development of CWAs as well as insecticides, research on developing protective materials against those toxins have become a priority. Simply, those poisonous molecules are referred to ...


Targeted Design Of Co-Continuous Nanostructures In Copolymers, Di Zeng Jan 2019

Targeted Design Of Co-Continuous Nanostructures In Copolymers, Di Zeng

Doctoral Dissertations

Microphase separated copolymers with nano-scale morphologies are critically important in designing next generation materials. Cocontinuous nanoscale structures, in which domains of multiple different phases each simultaneously percolate in three dimensions, provide opportunities to synergistically combine properties of the constituent polymers in a wide variety of contexts. While cocontinuous nanostructures are fabricated through equilibrium self-assembly of block or graft copolymers and kinetically trapped phase separation of polymer blends or crosslinked copolymer networks, their formation is highly sensitive to changes in chemical details, synthesis and/or processing conditions, bringing practical challenges to generalization to multiple systems.

In this dissertation, we focus on ...


Sequence Design Via Semidefinite Programming Relaxation And Randomized Projection, Dian Mo Jan 2019

Sequence Design Via Semidefinite Programming Relaxation And Randomized Projection, Dian Mo

Doctoral Dissertations

Wideband is a booming technology in the field of wireless communications. The receivers in wideband communication systems are expected to cover a very wide spectrum and adaptively extract the parts of interest. The literature has focused on mixing the input spectrum to baseband using a pseudorandom sequence modulation and recovering the received signals from linearly independent measurements by parallel branches to mitigate the pressures from required extreme high sampling frequency. However, a pseudorandom sequence provides no rejection for the strong interferers received together with weak signals from distant sources. The interferers cause significant distortion due to the nonlinearity of the ...


A Multiline Anchor Concept For Floating Offshore Wind Turbines, Casey Fontana Jan 2019

A Multiline Anchor Concept For Floating Offshore Wind Turbines, Casey Fontana

Doctoral Dissertations

Floating offshore wind turbines (FOWTs) hold great potential for the renewable energy industry, but capital costs remain high. In efforts to increase FOWT substructure efficiency and reduce costs, this thesis investigates a novel multiline anchor concept in which FOWTs share anchors instead of being moored separately. The goal of this thesis is to evaluate the force dynamics, design, and potential cost reduction of the system. Anchor forces are simulated using the NREL 5 MW reference turbine and OC4-DeepCwind semisubmersible platform, and multiline anchor force is computed as the vector sum of the contributing mooring line tensions.

The use of a ...


The Investigation Of Surface Barrier During Molecular Transport In Hierarchical Zeolites, Xiaoduo Qi Jan 2019

The Investigation Of Surface Barrier During Molecular Transport In Hierarchical Zeolites, Xiaoduo Qi

Doctoral Dissertations

Hierarchical zeolites with micropore lengths on the order of nanometers have been synthesized with the aim of reducing mass transfer limitation. However, due to large external surface to volume ratios, the mass transport in these materials can be hindered by a secondary rate limitation step imposed on the external surface of the zeolites. This has led to the general phenomenon referred to as “surface barriers”, which cause the enhancement in mass transport being far lower than expected. In order to fully unlock the potential of hierarchical zeolites, it is imperative to fundamentally understand the molecular transport in these new types ...


Equity And Efficiency In Multi-Modal Transportation Systems, Nicholas M. Fournier Jan 2019

Equity And Efficiency In Multi-Modal Transportation Systems, Nicholas M. Fournier

Doctoral Dissertations

The land-use pattern for many cities is a central business district surrounded by sprawling suburbs. This pattern can lead to an inefficient and congestion-prone transportation system due to a reliance on automobiles, because high-capacity transit is not efficient in low-density areas where insufficient travelers can access transit. This also poses an equity concern as the monetary cost of faster and more expensive travel disproportionately burdens low income travelers. This dissertation presents a deterministic approximation of a discrete choice model for mixed access and mainline transportation modes, meaning that travelers may use different modes to access a mainline system, such as ...


Power System Planning In Disparate Systems: Modeling Sustainability And Electricity Access, Destenie Nock Jan 2019

Power System Planning In Disparate Systems: Modeling Sustainability And Electricity Access, Destenie Nock

Doctoral Dissertations

Electricity goals around the world tend to focus on increasing social benefit through one of two avenues: (1) increasing overall system sustainability or (2) increasing access to electricity. These goals guide the transition of the power system. In pursuit of these goals decision makers will need modeling tools that can inform decisions, in a way that is flexible enough to include a wide range of preferences and goals. It is clear that the future generation mix of the power system will change, but the most sustainable solution, will change based on a country's goals. This dissertation will explore the ...


Laboratory Study Of The Geotechnical Properties Of Abraded Railway Ballast With Natural And Clay Mix Fouling, Andrew Rohrman Jan 2019

Laboratory Study Of The Geotechnical Properties Of Abraded Railway Ballast With Natural And Clay Mix Fouling, Andrew Rohrman

Doctoral Dissertations

With 140,000 miles of active track, railroad freight is the largest method of transporting goods in the United States. An important component of the railroad substructure is the gravel-size aggregate placed below the tracks, called ballast. The ballast is responsible for draining water away from the track, resisting forces from traffic loading, maintaining track position, and reducing loads to acceptable pressures for the subgrade. Ballast is typically selected to be highly angular and uniformly graded, but these characteristics are constantly changing under dynamic traffic loading. As the ballast is loaded, the particles abrade against each other, grinding off stone ...


Finite Element Simulation Of Bonded And Mechanically Anchored Shear Interfaces Of Externally Applied Frp Sheets To Concrete And Wood-Concrete Composites, Alaa Al-Sammari Jan 2019

Finite Element Simulation Of Bonded And Mechanically Anchored Shear Interfaces Of Externally Applied Frp Sheets To Concrete And Wood-Concrete Composites, Alaa Al-Sammari

Doctoral Dissertations

Composite construction is prevalent in advanced structural systems where components of different materials are combined in the same structure to improve the performance of strong and economic structural sections. Maintaining continuity between the different structural components to produce monolithic structural behavior is challenging because of differences in the mechanical properties of these materials in terms of stiffness, strength, and ductility. The different components of the composite section are typically joined using adhesives and/or mechanical anchors to produce partial or full composite action. This dissertation discusses two types of shear interfaces intended to result in structural composite behavior. The first ...


Function And Dissipation In Finite State Automata - From Computing To Intelligence And Back, Natesh Ganesh Jan 2019

Function And Dissipation In Finite State Automata - From Computing To Intelligence And Back, Natesh Ganesh

Doctoral Dissertations

Society has benefited from the technological revolution and the tremendous growth in computing powered by Moore's law. However, we are fast approaching the ultimate physical limits in terms of both device sizes and the associated energy dissipation. It is important to characterize these limits in a physically grounded and implementation-agnostic manner, in order to capture the fundamental energy dissipation costs associated with performing computing operations with classical information in nano-scale quantum systems. It is also necessary to identify and understand the effect of quantum in-distinguishability, noise, and device variability on these dissipation limits. Identifying these parameters is crucial to ...


Residual Stress Models For Large Eddy Simulation Of Stratified Turbulent Flows, Felipe Augusto Ventura De Bragança Alves Jan 2019

Residual Stress Models For Large Eddy Simulation Of Stratified Turbulent Flows, Felipe Augusto Ventura De Bragança Alves

Doctoral Dissertations

The residual stresses and scalar fluxes are required to close the momentum and scalar transport equations in simulations of turbulence that are not fully resolved in space.

In stratified turbulence, the stress and fluxes are statistically anisotropic unless the smallest resolved length scale is smaller than the Ozmidov scale and the buoyancy Reynolds number is sufficiently high for there to exist a range of scales that is statistically isotropic.

In this work, a tensorial basis set is derived analytically that potentially contains sufficient information about the anisotropic interaction between resolved and residual scales.

The residual stress tensor is evaluated by ...


Application Of Ground Penetrating Radar For Use In Thermal Conductivity Site Investigations, Aaron J. Rubin Jan 2019

Application Of Ground Penetrating Radar For Use In Thermal Conductivity Site Investigations, Aaron J. Rubin

Doctoral Dissertations

Measurement of soil thermal conductivity in-situ is important for many practical geotechnical and civil engineering applications. However, for a variety of reasons it can be difficult to measure in-situ. A novel method to estimate the thermal conductivity of sands based on electrical relative permittivity (dielectric constant) measurements and GPR data is presented. First, an analytical model to estimate thermal conductivity of soils was developed and validated using a database of thermal conductivity measurements. The new thermal conductivity model was then compared to existing models using a larger database of new and pervious thermal conductivity measurements conducted on a wide range ...


Chemical Stability And Performance Influence Of Choice Substituents And Core Conjugation Of Organic Semiconductors, Jack Ly Jan 2019

Chemical Stability And Performance Influence Of Choice Substituents And Core Conjugation Of Organic Semiconductors, Jack Ly

Doctoral Dissertations

Realizing organic based active materials for electronic devices, such as thin film transistors and photovoltaics, has been long sought after. Advancement in the field driven by chemists, engineers, and physicists alike have bolstered organic based semiconductor performance levels to rival those of traditional inorganic amorphous silicon-based devices. Within the field of organic semiconductors (OSC), two categories of active materials may be generalized: (1) polymer and (2) small molecule semiconductors. Each class of OSC inherently have their own advantages and disadvantages. Polymer semiconductors (PSC) allow a wide range in tunability via choice monomers and side chain engineering to illicit desirable energy ...


Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang Jan 2019

Development Of Functional Biomaterials Using Protein Building Blocks, Li-Sheng Wang

Doctoral Dissertations

Proteins have intrinsic molecular properties that are highly useful for materials applications, especially for biomaterials. My research has focused on translating these molecular properties to materials surface behavior. In one approach, I developed a fluorous-based thermal treatment strategy to generate stable thin films from a variety of naturally abundant proteins. The different surface properties generated from the choice of protein were utilized to modulate cell-surface interactions, prevent bacterial adhesions, and control drug loading/release. I have used nanoimprint lithography to generate patterned protein films for cell alignment. Coupling with inkjet printing deposition, I have fabricated mixed protein films with spatial ...


A Discrete-Time Technique For Linearity Enhancement Of Wideband Receivers, Mohammad Ghadiri Sadrabadi Jan 2019

A Discrete-Time Technique For Linearity Enhancement Of Wideband Receivers, Mohammad Ghadiri Sadrabadi

Doctoral Dissertations

A new signal processing technique is introduced to enhance the linearity performance of wideband radio frequency (RF) receivers. The proposed technique combines the advancements in mixer first architectures with a library of binary sequences as local oscillator signals to enable wide instantaneous bandwidth and high linearity for the RF receiver. To do so, N-bit pseudo-random-binary-sequences (PRBS) are used as local oscillator signals. The RF input signal is multiplied with the PRBS at the mixer and then averaged over the full sequence. This in effect reduces the amplitude of the signal and improves the overall linearity of the system. In order ...


Walking For Object Transport: An Examination Of The Coordinative Adaptations To Locomotor, Perceptual, And Manual Task Constraints, Avelino Amado Jan 2019

Walking For Object Transport: An Examination Of The Coordinative Adaptations To Locomotor, Perceptual, And Manual Task Constraints, Avelino Amado

Doctoral Dissertations

The goal of this dissertation was to understand how the intrinsic dynamics of gait adapt to support the performance of an ecologically relevant object transport task. A common object transport task is walking with a cup of water. Because the water can move relatively independent of the cup, the cup and water system is classified as a complex object. To model this task participants carried a cup with a wooden lid placed on top. On the lid there was a circular region with the same circumference as the cup and a ball. The object of the task was to keep ...


Evaluation Of The Effect Of Bottom Bar Splice Location On Performance Of Beams In Reinforced Concrete Perimeter Frames, Jorge Rivera Cruz Jan 2019

Evaluation Of The Effect Of Bottom Bar Splice Location On Performance Of Beams In Reinforced Concrete Perimeter Frames, Jorge Rivera Cruz

Doctoral Dissertations

The American Concrete Institute (ACI) Building Code Requirements for Structural Concrete and Commentary (ACI 318-14) indirectly accounts for resistance to progressive collapse by providing requirements for structural integrity in concrete structures. ACI 318-14 structural integrity requirements are intended to provide alternate load paths so that progressive collapse is avoided in the event of the unintended loss of an interior support.

ACI 318-14 §9.7.7.5 requires that splices of structural integrity reinforcement be designed as Class B splices near mid-span for top reinforcement and near the support for bottom reinforcement. However, ACI 318-14 does not provide a clear definition ...


Northeastern Species In Hybrid Cross Laminated Timber, Hamid Kaboli Jan 2019

Northeastern Species In Hybrid Cross Laminated Timber, Hamid Kaboli

Doctoral Dissertations

Known in the building industry throughout the world, Cross Laminated Timber (CLT) is a massive timber building material with outstanding structural, fire, and seismic properties. CLT is a cost-competitive, sustainable construction material is a good candidate as a substitute material for concrete, masonry, and steel, in mid-rise and high-rise buildings. CLT is perpendicular layers of dimensional lumbers usually laminated together and forming a massive structural panel. This dissertation explores the viability of utilizing Massachusetts grown Eastern Hemlock and Eastern White Pine in CLT panels as pure or in conjunction with other high-value wood products. 59% of Massachusetts’ lands are covered ...


Combining Human Factors And Data Science Methods To Evaluate The Use Of Free Text Communication Orders In Electronic Health Records, Swaminathan Kandaswamy Jan 2019

Combining Human Factors And Data Science Methods To Evaluate The Use Of Free Text Communication Orders In Electronic Health Records, Swaminathan Kandaswamy

Doctoral Dissertations

Medication errors are a leading cause of death in the United States. Electronic Health Records (EHR) along with Computerized Provider Order Entry (CPOE) are considered promising ways to reduce these errors. However, EHR systems have not eliminated medication errors. Moreover, in some cases they have facilitated errors due to issues such as poor usability and negative effects on clinical workflows. The use of unexpected free text within a CPOE system can serve as a marker that the system does not adequately support clinical workflow. Prior studies have looked at the use of free text within medication orders, but the inclusion ...


Sparsity In Machine Learning: An Information Selecting Perspective, Siwei Feng Jan 2019

Sparsity In Machine Learning: An Information Selecting Perspective, Siwei Feng

Doctoral Dissertations

Today we are living in a world awash with data. Large volumes of data are acquired, analyzed and applied to tasks through machine learning algorithms in nearly every area of science, business, and industry. For example, medical scientists analyze the gene expression data from a single specimen to learn the underlying causes of disease (e.g. cancer) and choose the best treatment; retailers can know more about customers' shopping habits from retail data to adjust their business strategies to better appeal to customers; suppliers can enhance supply chain success through supply chain systems built on knowledge sharing. However, it is ...