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Full-Text Articles in Engineering
Tissue Engineering Composite Biomimetic Gelatin Sponges For Bone Regeneration, Isaac Rodriguez
Tissue Engineering Composite Biomimetic Gelatin Sponges For Bone Regeneration, Isaac Rodriguez
Theses and Dissertations
The field of tissue engineering aims to develop viable substitutes with the ability to repair and regenerate the functions of damaged tissue. Common practices to supplement bone regeneration in larger defects include bone graft biomaterials such as autografts, allografts, xenografts, and synthetic biomaterials. Autologous bone grafting is the current gold-standard procedure used to replace missing or damaged bone. However, these grafts have disadvantages such as donor site morbidity, limited availability, and the need for a secondary surgery. The focus of this study is to tissue engineer a lyophilized gelatin composite sponge composed of hydroxyapatite (HA), chitin whiskers (CW), and preparations …
Mineralization Potential Of Electrospun Pdo-Nha-Fibrinogen Scaffolds Intended For Cleft Palate Repair, Isaac Rodriguez
Mineralization Potential Of Electrospun Pdo-Nha-Fibrinogen Scaffolds Intended For Cleft Palate Repair, Isaac Rodriguez
Theses and Dissertations
The overall goal of this study was to identify mineralized scaffolds which can serve as potential alternatives to bone graft substitutes intended for cleft palate repair. The aim of this preliminary study was to evaluate the role of fibrinogen (Fg) and nano-hydroxyapatite (nHA) in enhancing mineralization potential of polydioxanone (PDO) electrospun scaffolds. Scaffolds were fabricated by blending PDO:nHA:Fg in the following weight ratios: 100:0:0, 50:25:25, 50:50:0, 50:0:50, 0:0:100 and 0:50:50. Scaffolds were immersed in different simulated body fluids for 5 and 14 days to induce mineralization. The inclusion of fibrinogen induced sheet-like mineralization while individual fiber mineralization was noticed in …
Fabrication And Characterization Of Bioactive, Composite Electrospun Bone Tissue Engineering Scaffolds Intended For Cleft Palate Repair, Parthasarathy Madurantakam
Fabrication And Characterization Of Bioactive, Composite Electrospun Bone Tissue Engineering Scaffolds Intended For Cleft Palate Repair, Parthasarathy Madurantakam
Theses and Dissertations
Tissue Engineering is a scientific discipline that aims to regenerate tissues and organs that are diseased, lost or congenitally absent. It encompasses the use of suitable synthetic equivalents of native extracellular matrix that may or may not be supplemented with cells or relevant growth factors. Such scaffolds are designed to reside at the site of implantation for a variable period of time during which they induce the regeneration of native tissue. During this time, they also provide a template for new cells to attach, infiltrate, differentiate into appropriate phenotype and eventually restore function of the concerned tissue. Among the factors …