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Full-Text Articles in Engineering
Retaining Thermoresponsive Poly(Vinyl Methyl Ether) To Cellulose Via (3-Aminopropyl)Triethoxylsilane Network, Grace Tolhurst
Retaining Thermoresponsive Poly(Vinyl Methyl Ether) To Cellulose Via (3-Aminopropyl)Triethoxylsilane Network, Grace Tolhurst
Williams Honors College, Honors Research Projects
Stimuli-responsive supports and devices that are fabricated from inexpensive materials are attractive candidates for a variety of applications, such as environmental protection, and regenerative medicine. Poly(vinyl methyl ether) (PVME), a thermoresponsive polymer (TRP), has recently been used as thermoresponsive cell culture supports for cell growth/proliferation followed with cell/cell sheet harvesting by simply switching temperature. Cellulose is an attractive candidate to replace glass/silicone supports as it is inexpensive and environmentally friendly. This project focuses on retaining PVME to the cellulose membrane via 3-aminopropyltriethoxysilane (APTES) network to generate TR membranes and flexible liners that can be incorporated into bioreactors for producing cells …
Retention And Stability Of Polystyrene Sulfonic Acid And Polyethylene Glycol Anti- Fouling Films With 3-Aminopropyltriethoxysilane Coupling Agent, Brian Cameron
Williams Honors College, Honors Research Projects
Fouling is a process where particles, proteins, or microorganisms will accumulate onto a material [2]. This can lead to biofilms in medical implants, which can trap and create drug resistant bacteria [5]. Due to this, the study and creation of anti-fouling polymeric films that is stable in aqueous environments is essential. The goal of this study is to utilize APTES to retain the already studied PSS-PEG anti-fouling films. The films that are created is a thermally crosslinked network of the polystyrene sulfonic acid (PSS) and polyethylene glycol (PEG) with differing mass fractions (75- 25 and 55-45 PSS-PEG). To retain the …
Effects Of Micro-Features On Cell Detachment From Poly(N-Isopropylacrylamide) Coated Polydimethylsiloxane Membranes, Luke Webel
Williams Honors College, Honors Research Projects
The tested hypothesis was that features on polydimethylsiloxane (PDMS) surfaces coated with a poly(N-isopropylacrylamide)/aminopropyltriethoxysilane or pNIPAAM/APTES thin film would accelerate cell detachment than the film coated on a unfeatured surface. This project tested samples with features generated by molds, wrinkling, and sandpaper roughened substrates. Surface feature generation methods were limited to mechanical means, and characterized by microscopy and strain rates. 50/50 mixtures of 1.5 wt.% pNIPAAM/ APTES were used to coat thin films (30-40 nm) on PDMS membranes by spin-coating, and the coated membranes were thermally annealed to chemically graft pNIPAAm/APTES on the membrane and their thermo-responsive property was assessed …
Modification Of Bacterial Cellulose Using Organosilanes To Enhance Cell Adhesion And Growth, Kristi Ferrato
Modification Of Bacterial Cellulose Using Organosilanes To Enhance Cell Adhesion And Growth, Kristi Ferrato
Williams Honors College, Honors Research Projects
In this project, drying bacterial cellulose (BC) to maintain its structural integrity, and treating BC with organosilanes 3-aminopropyltriethoxysilane (APTES) and (3-Mercaptopropyl)trimethoxysilane (MPTMS) as well as with various concentration of gelatin to increase the cells per area was studied. Drying BC with hexamethyldisilazane (HMDS) by soaking the BC in ascending concentrations of ethanol and HMDS did not protect the structural integrity of the BC grown in lab but did for the BC grown in Dr. Siriporn Taokaew’s lab. Freeze drying also did not fully protect the structural integrity as the BC was placed in a freezer for several hours at -20oC …
Stability And Retention Enhancement Of Low Fouling Polystyrene Sulfonic Acid (Pss) And Polyethylene Glycol (Peg) Blend Films With Silane Coupling Agents, Sean Stybel
Williams Honors College, Honors Research Projects
The goal of this research project was to apply silane coupling agents for enhanced stability and retention of a low fouling polymeric coating to an inorganic substrate. A blend of polystyrene sulfonic acid (PSS) and polyethylene glycol (PEG) was crosslinked in order to create a low fouling film. The film was prepared by spin coating a PSS-PEG solution on an inorganic substrate coated with a layer of a silane coupling agent (3-aminopropyltriethoxysilane, APTES, solution), followed by thermal curing. The research was limited to less than one year and only used lab equipment available at the University of Akron. Stability and …