Engineering Commons^™

Design Of Novel Drug Delivery System And Optimal Dosage Regimens, Kwang Seok Kim

Dissertations

Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was created and posted on a website for free access. The second project dealt with the transdermal heat-assisted delivery of corticosterone. Heat conduction and drug diffusion through the patch and the skin were …

Shear Strengthening Of Rc Beams Using Carbon Fiber Reinforced Polymer Laminates, Zhichao Zhang

Dissertations

Shear failure is catastrophic and occurs usually without advanced warning, thus it is desirable that the beam fails in flexure rather than in shear. Many existing reinforced concrete (RC) members are found to be deficient in shear strength and need to be repaired. Deficiencies occur due to several reasons such as insufficient shear reinforcement or reduction in steel area due to corrosion, increased service load, and construction defects. Externally bonded reinforcement such as Carbon Fiber Reinforced Polymer (CFRP) provides an excellent solution in these situations.

In order to investigate the shear behavior of RC beams with externally bonded CFRP shear …

Analytical And Experimental Study Of Investment Casting With Laser Stereolithography Models, Wen-Long Yao

Dissertations

This dissertation presents an analytical and experimental investigation of ceramic shell cracking during the burnout process in investment casting with internally webbed laser stereolithography (SLA) patterns. Included in the consideration are the cracking temperature of the ceramic shell, the web link buckling temperature, and the glass transition temperature of the epoxy resin. The hypothesis is that shell cracking will occur when the cracking temperature is lower than the glass transition temperature and the web buckling temperature.

An analytical and experimental study has been conducted, with the cross-sectional area, the span length of the web structure, and the shell thickness being …

Parameter Optimization For Curl Distortion In Building Parts Using 3-D Laser Stereolithography, Laurel A. Hanesian

Theses

The curl distortions in rapid prototyping using 3-D laser stereo lithography occur as the top layers shrink after being drawn and attaching to the bottom layers. The amount of curl is dependent upon the how much shrinkage the layer has finished prior to adhesion. It is also dependent on how deep the cure of the top layer amounts to as it adheres into the bottom layer. This thesis investigated the effect of build parameters on the distortions associated with the diagnostic 'Letter-H' shaped test part. The same parameters were also considered in a time optimization study, using calculated, predicted results …

A Study To Analyze And Improve Mechanical And Electro-Mechanical Designs Using Design For Quality Manufacturability (Dfqm) Technique, Bhavani P. Veerapaneni

Theses

The competitive nature of modern manufacturing demands that an innovative approach be used to build advanced and robust designs. Shortening the product development time, which is the period from initial design to full production, is a priority to most manufacturers today. Design for Quality Manufacturability (DFQM) is a methodology to address manufacturing / assembly quality issues during product design. As a consequence DFQM helps shorten the product development time.

The DFQM methodology addresses the issue of quality manufacturability (QM) - the likely hood that defects will occur during the manufacture of a product in a standard plant. The DFQM architecture …

Design Improvement Using Reverse Analysis In Design For Quality Manufacturability, Vikram V. Datla

Theses

The competitive needs of modern manufacturing demands that innovative approaches be used to gain an edge over the competitors. least Product design is one of the key dimensions wazzu in which companies can excel. Shortening the product design cycle so as to rapidly launch defect free products, is the goal of most companies. Design for Quality Manufacturability (DFQM) is a technique used to evaluate the quality manufacturability of a product at the design stage, so as to eliminate quality problems during production.

DFQM provides a means for relating the activities of quality improvement, product design and manufacturability analysis. The basis …

Design For Quality Manufacturability Analysis Of Missing/Misplaced Parts And Part Interference, Altaf Yusuf Tamboo

Theses

Design for Quality Manufacturability (DFQM) is an approach that addresses the issue of quality manufacturability (QM) - the likelihood that defects will occur during manufacture of a product in a standard plant. The DFQM methodology is based on the premise that defects found in assembled products are often influenced by some features of the design and/or assembly process (influencing factors). These influencing factors cause defects in the presence of certain error catalysts.

One of the influencing factors is geometrical features such as shape and symmetry. A classification scheme for part shape and symmetry is developed. This scheme is summarized in …

Design For Manufacturability : Re-Design Of Pencil Sharpener For The Ease Of Assembly, Amit R. Rathod

Theses

A Design For Manufacturability (DFM) approach is used to analyze the existing design of a pencil sharpener, and to reduce and re-design the parts of pencil sharpener for the ease of assembly. The procedure for the selection of a suitable and economical assembly method is based on the Boothroyd and Dewhurst methods. Analysis of the initial design for manual assembly and re-design for automatic as well as manual assembly is presented. An algorithmic approach for simplified generation of all mechanical assembly sequences and selection of the assembly sequences is presented using De Fazio and Whitney approach.

Design For Manufacturability, Kocherlakota Sreedhar

Theses

Design for Manufacturability represents a new awareness of the importance of design as the first manufacturing step. It recognizes that a company cannot meet all its objectives with isolated design and manufacturing operations. The Design for Manufacturability approach embodies certain underlying imperatives that help maintain communication between all components of the Manufacturing and Design system and permit flexibility to adopt and to modify design during each stage of the product realization. Design for Manufacturability cannot be bought or sold and it should be implemented by management. Complete support of management to the implementation is very important to the success of …