Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Engineering
Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan
Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan
ETD Archive
Understanding anatomical connectivity is crucial for improving outcomes of deep brain stimulation surgery. Tractography is a promising method for noninvasively investigating anatomical connectivity, but connections between subcortical regions have not been closely examined by this method. As many connections to subcortical regions converge at the internal capsule (IC), we investigate the connectivity through the IC to three subcortical nuclei (caudate, lentiform nucleus, and thalamus) in 6 macaques. We show that a statistical correction for a known distance-related artifact in tractography results in large changes in connectivity patterns. Our results suggest that care should be taken in using tractography to assess …
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
ETD Archive
Amyotrophic lateral sclerosis (ALS) is the commonest adult motor neuron disease (MND) which causes progressive muscle paralysis and death usually within 5 years of symptom onset. As a result, only ╠â30,000 individuals in the United States are afflicted at any one time even though 5,000 or more individuals are diagnosed yearly. The diagnosis of ALS requires evidence of degeneration in upper motor neurons (UMNs) in the brain and in lower motor neurons (LMNs) that exit the brainstem and spinal cord to innervate skeletal muscles. Diagnosis can be incorrect or delayed when disease is early or atypical because non-invasive objective tests …
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
ETD Archive
Novel tyramine-based hyaluronan (HA) and collagen hydrogels have been developed in which cross-linking is accomplished via peroxidase-mediated dityramine linkages allowing direct cross-linking in vivo. These TB hydrogels possess advantageous physical properties, which include excellent biocompatibility and the ability to mimic the biological, structural and mechanical properties of normal, healthy tissues, including cartilage, and thus provide for synthetic, implantable biomaterials suitable for a wide range of tissue types. The efficacy of these TB-hydrogels has been previously tested in a number of clinically relevant animal models, which have evaluated their applicability for the repair/replacement of various tissues, including cartilage. Nevertheless, there exists …